Apolipoprotein E gene in Parkinson's disease, Lewy body dementia and Alzheimer's disease

D. St. Clair*

*Corresponding author for this work

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Apolipoprotein E (Apo E) epsilon 4 allele is a risk factor for early and late onset Alzheimer's disease. This prompted us to examine other neurophyschiatric phenotypes. Epsilon 4 allele was significantly enriched in Lewy body dementia (N = 39) but not in Parkinson's disease (n = 50) or Schizophrenia (n = 175) compared to aged non-demented controls (n = 47) and the Scottish population (n = 400). We conclude that Lewy body disease should be regarded as a variant of Alzheimer's but not Parkinson's disease.

Original languageEnglish
Pages (from-to)161-165
Number of pages5
JournalJournal of Neural Transmission, Supplement
Issue number51
Publication statusPublished - 1 Feb 1997

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