Apolipoprotein E is a genetic risk factor for fetal iodine deficiency disorder in China

H Y Wang, F C Zhang, J J Gao, J B Fan, P Liu, Z J Zheng, H Xi, Y Sun, X C Gao, T Z Huang, Z J Ke, G R Guo, G Y Feng, G Breen, D St Clair, L He

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Fetal iodine deficiency disorder (FIDD) is the principal form of endemic cretinism, and the most common cause of preventable mental deficiency in the world. However not everyone at risk develops FIDD and familial aggregation is common. This suggests that genetic factors may also be involved. The Apolipoprotein E (APOE) gene encodes for a lipoprotein that possesses a thyroid hormone binding domain, and APOE genotype may affect the efficiency with which thyroid hormone influences neuronal cell growth during the first and second trimesters of fetal development. We have compared ApoE genotypes in 91 FIDD cases with 154 local control subjects, recruited from three iodine deficiency areas in central China. We have also genotyped 42 FIDD family cases and 158 normal individuals from the families of local controls, and 375 population controls from Shanghai, APOE epsilon 4 genotypes were significantly enriched in FIDD probands from each of the three iodine deficiency areas; the epsilon 4 allele frequency was 16% vs 6% in controls. The same effect was also observed when we compared FIDD family cases with controls and control families. Our data suggest that in iodine-deficient areas, the APOE epsilon 4 allele is a genetic risk factor for FIDD, The phenomenon may affect population selection and contribute to the low frequency of the epsilon 4 allele in Chinese compared to Caucasian populations.

Original languageEnglish
Pages (from-to)363-368
Number of pages6
JournalMolecular Psychiatry
Volume5
Publication statusPublished - 2000

Keywords

  • fetal iodine deficiency disorder
  • endemic cretinism
  • APOE genotype
  • apolipoprotein
  • China
  • mental retardation
  • ALZHEIMERS-DISEASE
  • ENDEMIC CRETINISM
  • ALLELE
  • BRAIN

Cite this

Wang, H. Y., Zhang, F. C., Gao, J. J., Fan, J. B., Liu, P., Zheng, Z. J., ... He, L. (2000). Apolipoprotein E is a genetic risk factor for fetal iodine deficiency disorder in China. Molecular Psychiatry, 5, 363-368.

Apolipoprotein E is a genetic risk factor for fetal iodine deficiency disorder in China. / Wang, H Y ; Zhang, F C ; Gao, J J ; Fan, J B ; Liu, P ; Zheng, Z J ; Xi, H ; Sun, Y ; Gao, X C ; Huang, T Z ; Ke, Z J ; Guo, G R ; Feng, G Y ; Breen, G ; St Clair, D ; He, L .

In: Molecular Psychiatry, Vol. 5, 2000, p. 363-368.

Research output: Contribution to journalArticle

Wang, HY, Zhang, FC, Gao, JJ, Fan, JB, Liu, P, Zheng, ZJ, Xi, H, Sun, Y, Gao, XC, Huang, TZ, Ke, ZJ, Guo, GR, Feng, GY, Breen, G, St Clair, D & He, L 2000, 'Apolipoprotein E is a genetic risk factor for fetal iodine deficiency disorder in China', Molecular Psychiatry, vol. 5, pp. 363-368.
Wang HY, Zhang FC, Gao JJ, Fan JB, Liu P, Zheng ZJ et al. Apolipoprotein E is a genetic risk factor for fetal iodine deficiency disorder in China. Molecular Psychiatry. 2000;5:363-368.
Wang, H Y ; Zhang, F C ; Gao, J J ; Fan, J B ; Liu, P ; Zheng, Z J ; Xi, H ; Sun, Y ; Gao, X C ; Huang, T Z ; Ke, Z J ; Guo, G R ; Feng, G Y ; Breen, G ; St Clair, D ; He, L . / Apolipoprotein E is a genetic risk factor for fetal iodine deficiency disorder in China. In: Molecular Psychiatry. 2000 ; Vol. 5. pp. 363-368.
@article{7f500dc6e3724b81a477ef5aff2cc0c7,
title = "Apolipoprotein E is a genetic risk factor for fetal iodine deficiency disorder in China",
abstract = "Fetal iodine deficiency disorder (FIDD) is the principal form of endemic cretinism, and the most common cause of preventable mental deficiency in the world. However not everyone at risk develops FIDD and familial aggregation is common. This suggests that genetic factors may also be involved. The Apolipoprotein E (APOE) gene encodes for a lipoprotein that possesses a thyroid hormone binding domain, and APOE genotype may affect the efficiency with which thyroid hormone influences neuronal cell growth during the first and second trimesters of fetal development. We have compared ApoE genotypes in 91 FIDD cases with 154 local control subjects, recruited from three iodine deficiency areas in central China. We have also genotyped 42 FIDD family cases and 158 normal individuals from the families of local controls, and 375 population controls from Shanghai, APOE epsilon 4 genotypes were significantly enriched in FIDD probands from each of the three iodine deficiency areas; the epsilon 4 allele frequency was 16{\%} vs 6{\%} in controls. The same effect was also observed when we compared FIDD family cases with controls and control families. Our data suggest that in iodine-deficient areas, the APOE epsilon 4 allele is a genetic risk factor for FIDD, The phenomenon may affect population selection and contribute to the low frequency of the epsilon 4 allele in Chinese compared to Caucasian populations.",
keywords = "fetal iodine deficiency disorder, endemic cretinism, APOE genotype, apolipoprotein, China, mental retardation, ALZHEIMERS-DISEASE, ENDEMIC CRETINISM, ALLELE, BRAIN",
author = "Wang, {H Y} and Zhang, {F C} and Gao, {J J} and Fan, {J B} and P Liu and Zheng, {Z J} and H Xi and Y Sun and Gao, {X C} and Huang, {T Z} and Ke, {Z J} and Guo, {G R} and Feng, {G Y} and G Breen and {St Clair}, D and L He",
year = "2000",
language = "English",
volume = "5",
pages = "363--368",
journal = "Molecular Psychiatry",
issn = "1359-4184",
publisher = "Nature Publishing Group",

}

TY - JOUR

T1 - Apolipoprotein E is a genetic risk factor for fetal iodine deficiency disorder in China

AU - Wang, H Y

AU - Zhang, F C

AU - Gao, J J

AU - Fan, J B

AU - Liu, P

AU - Zheng, Z J

AU - Xi, H

AU - Sun, Y

AU - Gao, X C

AU - Huang, T Z

AU - Ke, Z J

AU - Guo, G R

AU - Feng, G Y

AU - Breen, G

AU - St Clair, D

AU - He, L

PY - 2000

Y1 - 2000

N2 - Fetal iodine deficiency disorder (FIDD) is the principal form of endemic cretinism, and the most common cause of preventable mental deficiency in the world. However not everyone at risk develops FIDD and familial aggregation is common. This suggests that genetic factors may also be involved. The Apolipoprotein E (APOE) gene encodes for a lipoprotein that possesses a thyroid hormone binding domain, and APOE genotype may affect the efficiency with which thyroid hormone influences neuronal cell growth during the first and second trimesters of fetal development. We have compared ApoE genotypes in 91 FIDD cases with 154 local control subjects, recruited from three iodine deficiency areas in central China. We have also genotyped 42 FIDD family cases and 158 normal individuals from the families of local controls, and 375 population controls from Shanghai, APOE epsilon 4 genotypes were significantly enriched in FIDD probands from each of the three iodine deficiency areas; the epsilon 4 allele frequency was 16% vs 6% in controls. The same effect was also observed when we compared FIDD family cases with controls and control families. Our data suggest that in iodine-deficient areas, the APOE epsilon 4 allele is a genetic risk factor for FIDD, The phenomenon may affect population selection and contribute to the low frequency of the epsilon 4 allele in Chinese compared to Caucasian populations.

AB - Fetal iodine deficiency disorder (FIDD) is the principal form of endemic cretinism, and the most common cause of preventable mental deficiency in the world. However not everyone at risk develops FIDD and familial aggregation is common. This suggests that genetic factors may also be involved. The Apolipoprotein E (APOE) gene encodes for a lipoprotein that possesses a thyroid hormone binding domain, and APOE genotype may affect the efficiency with which thyroid hormone influences neuronal cell growth during the first and second trimesters of fetal development. We have compared ApoE genotypes in 91 FIDD cases with 154 local control subjects, recruited from three iodine deficiency areas in central China. We have also genotyped 42 FIDD family cases and 158 normal individuals from the families of local controls, and 375 population controls from Shanghai, APOE epsilon 4 genotypes were significantly enriched in FIDD probands from each of the three iodine deficiency areas; the epsilon 4 allele frequency was 16% vs 6% in controls. The same effect was also observed when we compared FIDD family cases with controls and control families. Our data suggest that in iodine-deficient areas, the APOE epsilon 4 allele is a genetic risk factor for FIDD, The phenomenon may affect population selection and contribute to the low frequency of the epsilon 4 allele in Chinese compared to Caucasian populations.

KW - fetal iodine deficiency disorder

KW - endemic cretinism

KW - APOE genotype

KW - apolipoprotein

KW - China

KW - mental retardation

KW - ALZHEIMERS-DISEASE

KW - ENDEMIC CRETINISM

KW - ALLELE

KW - BRAIN

M3 - Article

VL - 5

SP - 363

EP - 368

JO - Molecular Psychiatry

JF - Molecular Psychiatry

SN - 1359-4184

ER -