Application of an algorithm to analyze patterns of intermittent oral corticosteroid use in asthma

John Haughney; Trung N Tran; Heath Heatley; Arnaud Bourdin; Andrew Menzies-Gow; David J Jackson; Ekaterina Maslova; Jatin Chapaneri; Derek Skinner; Victoria Carter; Jeffrey Shi Kai Chan; David Price

doi:10.1038/s41533-023-00331-0

Application of an algorithm to analyze patterns of intermittent oral corticosteroid use in asthma

John Haughney, Trung N Tran, Heath Heatley, Arnaud Bourdin, Andrew Menzies-Gow, David J Jackson, Ekaterina Maslova, Jatin Chapaneri, Derek Skinner, Victoria Carter, Jeffrey Shi Kai Chan, David Price^* (Corresponding Author)

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

An algorithm to describe patterns of intermittent oral corticosteroid use in the UK (n = 476,167) found that one-third of patients receiving intermittent oral corticosteroids for asthma only had short gaps (<90 days) between oral corticosteroid prescriptions sometime during follow-up. The increasing frequency pattern was more likely in patients with greater asthma severity and with more short-acting β2-agonist use at baseline. Our approach may provide a clinically relevant representation of intermittent oral corticosteroid use in asthma.

Original language	English
Article number	9
Number of pages	5
Journal	npj Primary Care Respiratory Medicine
Volume	33
Issue number	1
Early online date	4 Mar 2023
DOIs	https://doi.org/10.1038/s41533-023-00331-0
Publication status	Published - 4 Mar 2023

Keywords

Humans
Algorithms
Asthma
Adrenal Cortex Hormones
Prescriptions

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Cite this

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title = "Application of an algorithm to analyze patterns of intermittent oral corticosteroid use in asthma",

abstract = "An algorithm to describe patterns of intermittent oral corticosteroid use in the UK (n = 476,167) found that one-third of patients receiving intermittent oral corticosteroids for asthma only had short gaps (<90 days) between oral corticosteroid prescriptions sometime during follow-up. The increasing frequency pattern was more likely in patients with greater asthma severity and with more short-acting β2-agonist use at baseline. Our approach may provide a clinically relevant representation of intermittent oral corticosteroid use in asthma.",

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author = "John Haughney and Tran, {Trung N} and Heath Heatley and Arnaud Bourdin and Andrew Menzies-Gow and Jackson, {David J} and Ekaterina Maslova and Jatin Chapaneri and Derek Skinner and Victoria Carter and Chan, {Jeffrey Shi Kai} and David Price",

note = "Acknowledgements This project is based in part/wholly on data from the Optimum Patient Care Research Database (opcrd.co.uk) obtained under licence from Optimum Patient Care Limited and its execution is approved by recognized experts affiliated to the Respiratory Effectiveness Group. However, the interpretation and conclusion contained in this manuscript are those of the authors alone. AstraZeneca funded the study and had a role in study design and data interpretation. The Observational & Pragmatic Research Institute had a role in study design and delivered the study protocol, data analysis, data interpretation and study report. The Observational & Pragmatic Research Institute received no funding for manuscript writing. The corresponding author had full access to all the data and had final responsibility to submit for publication. We would like to thank Sam Hijazi and Stefan Courtney for providing medical writing support, which was funded by AstraZeneca in accordance with Good Publication Practice (GPP3) guidelines (http://www.ismpp.org/gpp3).",

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AU - Tran, Trung N

AU - Heatley, Heath

AU - Bourdin, Arnaud

AU - Menzies-Gow, Andrew

AU - Jackson, David J

AU - Maslova, Ekaterina

AU - Chapaneri, Jatin

AU - Skinner, Derek

AU - Carter, Victoria

AU - Chan, Jeffrey Shi Kai

AU - Price, David

N1 - Acknowledgements This project is based in part/wholly on data from the Optimum Patient Care Research Database (opcrd.co.uk) obtained under licence from Optimum Patient Care Limited and its execution is approved by recognized experts affiliated to the Respiratory Effectiveness Group. However, the interpretation and conclusion contained in this manuscript are those of the authors alone. AstraZeneca funded the study and had a role in study design and data interpretation. The Observational & Pragmatic Research Institute had a role in study design and delivered the study protocol, data analysis, data interpretation and study report. The Observational & Pragmatic Research Institute received no funding for manuscript writing. The corresponding author had full access to all the data and had final responsibility to submit for publication. We would like to thank Sam Hijazi and Stefan Courtney for providing medical writing support, which was funded by AstraZeneca in accordance with Good Publication Practice (GPP3) guidelines (http://www.ismpp.org/gpp3).

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KW - Asthma

KW - Adrenal Cortex Hormones

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Application of an algorithm to analyze patterns of intermittent oral corticosteroid use in asthma

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