Application of iodine-123-labeled isopropylamphetamine imaging to the study of dementia

P. Sharp, H. Gemmell, G. Cherryman, J. Besson, J. Crawford, F. Smith

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Abstract

Forty-seven patients diagnosed as clinically demented were imaged with 123I isopropylamphetamine (IMP). All of these patients also had a nuclear magnetic resonance (NMR) study. In those patients diagnosed as having senile dementia of the Alzheimer type a bilateral reduction in IMP uptake in the temporo-parieto-occipital region was always seen. The NMR appearances were normal in 64% of these sites. The IMP images of patients with multi-infarct dementia varied from normal to marked focal deficits. There was, however, a much closer agreement between the abnormalities seen on the IMP and NMR images. In alcoholic dementia no focal areas of reduced IMP uptake were seen, although the uptake was generally irregular. In both Korsakoff's psychosis and Huntington's chorea the IMP uptake pattern and the NMR study were normal.

Original languageEnglish
Pages (from-to)761-768
Number of pages8
JournalJournal of Nuclear Medicine
Volume27
Issue number6
Publication statusPublished - 1 Dec 1986

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Iodine
Dementia
Magnetic Resonance Spectroscopy
Korsakoff Syndrome
Multi-Infarct Dementia
Occipital Lobe
Huntington Disease
Alzheimer Disease

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Application of iodine-123-labeled isopropylamphetamine imaging to the study of dementia. / Sharp, P.; Gemmell, H.; Cherryman, G.; Besson, J.; Crawford, J.; Smith, F.

In: Journal of Nuclear Medicine, Vol. 27, No. 6, 01.12.1986, p. 761-768.

Research output: Contribution to journalArticle

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