Are interleukin-1 gene polymorphisms risk factors or disese modifiers in Alzheimer's disease?

E. K. Green, J. M. Harris, H.a. Lemmon, J. C. Lambert, M. C. Chartier-Harlin, David Malcolm St Clair, A. Mann, T. Iwatsubo, C. Lendon

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Abstract

Polymorphisms in the interleukin-1 genes, IL-1A and IL-1B, have been associated with AD, but not in all studies. The authors genotyped the IL-1A(-889) and IL-1B(-511) polymorphisms in large independent cohorts of 503 control individuals and 395 patients with AD, and a further 100 with brain Abeta load. No evidence was found of risk for AD with these variants, nor of an effect on age at onset. However, an impact of IL-1B-(511) on Abeta(40) load (P < 0.05) was detected.

Original languageEnglish
Pages (from-to)1566-1568
Number of pages2
JournalNeurology
Volume58
Publication statusPublished - 2002

Keywords

  • ALZHEIMERS-DISEASE
  • SENILE PLAQUES
  • ASSOCIATION

Cite this

Green, E. K., Harris, J. M., Lemmon, H. A., Lambert, J. C., Chartier-Harlin, M. C., St Clair, D. M., Mann, A., Iwatsubo, T., & Lendon, C. (2002). Are interleukin-1 gene polymorphisms risk factors or disese modifiers in Alzheimer's disease? Neurology, 58, 1566-1568.