Abstract
Polymorphisms in the interleukin-1 genes, IL-1A and IL-1B, have been associated with AD, but not in all studies. The authors genotyped the IL-1A(-889) and IL-1B(-511) polymorphisms in large independent cohorts of 503 control individuals and 395 patients with AD, and a further 100 with brain Abeta load. No evidence was found of risk for AD with these variants, nor of an effect on age at onset. However, an impact of IL-1B-(511) on Abeta(40) load (P < 0.05) was detected.
| Original language | English |
|---|---|
| Pages (from-to) | 1566-1568 |
| Number of pages | 2 |
| Journal | Neurology |
| Volume | 58 |
| Publication status | Published - 2002 |
Keywords
- ALZHEIMERS-DISEASE
- SENILE PLAQUES
- ASSOCIATION