Are interleukin-1 gene polymorphisms risk factors or disese modifiers in Alzheimer's disease?

E. K. Green, J. M. Harris, H.a. Lemmon, J. C. Lambert, M. C. Chartier-Harlin, David Malcolm St Clair, A. Mann, T. Iwatsubo, C. Lendon

Research output: Contribution to journalArticle

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Abstract

Polymorphisms in the interleukin-1 genes, IL-1A and IL-1B, have been associated with AD, but not in all studies. The authors genotyped the IL-1A(-889) and IL-1B(-511) polymorphisms in large independent cohorts of 503 control individuals and 395 patients with AD, and a further 100 with brain Abeta load. No evidence was found of risk for AD with these variants, nor of an effect on age at onset. However, an impact of IL-1B-(511) on Abeta(40) load (P < 0.05) was detected.

Original languageEnglish
Pages (from-to)1566-1568
Number of pages2
JournalNeurology
Volume58
Publication statusPublished - 2002

Keywords

  • ALZHEIMERS-DISEASE
  • SENILE PLAQUES
  • ASSOCIATION

Cite this

Green, E. K., Harris, J. M., Lemmon, H. A., Lambert, J. C., Chartier-Harlin, M. C., St Clair, D. M., ... Lendon, C. (2002). Are interleukin-1 gene polymorphisms risk factors or disese modifiers in Alzheimer's disease? Neurology, 58, 1566-1568.

Are interleukin-1 gene polymorphisms risk factors or disese modifiers in Alzheimer's disease? / Green, E. K.; Harris, J. M.; Lemmon, H.a.; Lambert, J. C.; Chartier-Harlin, M. C.; St Clair, David Malcolm; Mann, A.; Iwatsubo, T.; Lendon, C.

In: Neurology, Vol. 58, 2002, p. 1566-1568.

Research output: Contribution to journalArticle

Green, EK, Harris, JM, Lemmon, HA, Lambert, JC, Chartier-Harlin, MC, St Clair, DM, Mann, A, Iwatsubo, T & Lendon, C 2002, 'Are interleukin-1 gene polymorphisms risk factors or disese modifiers in Alzheimer's disease?', Neurology, vol. 58, pp. 1566-1568.
Green EK, Harris JM, Lemmon HA, Lambert JC, Chartier-Harlin MC, St Clair DM et al. Are interleukin-1 gene polymorphisms risk factors or disese modifiers in Alzheimer's disease? Neurology. 2002;58:1566-1568.
Green, E. K. ; Harris, J. M. ; Lemmon, H.a. ; Lambert, J. C. ; Chartier-Harlin, M. C. ; St Clair, David Malcolm ; Mann, A. ; Iwatsubo, T. ; Lendon, C. / Are interleukin-1 gene polymorphisms risk factors or disese modifiers in Alzheimer's disease?. In: Neurology. 2002 ; Vol. 58. pp. 1566-1568.
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AU - Green, E. K.

AU - Harris, J. M.

AU - Lemmon, H.a.

AU - Lambert, J. C.

AU - Chartier-Harlin, M. C.

AU - St Clair, David Malcolm

AU - Mann, A.

AU - Iwatsubo, T.

AU - Lendon, C.

PY - 2002

Y1 - 2002

N2 - Polymorphisms in the interleukin-1 genes, IL-1A and IL-1B, have been associated with AD, but not in all studies. The authors genotyped the IL-1A(-889) and IL-1B(-511) polymorphisms in large independent cohorts of 503 control individuals and 395 patients with AD, and a further 100 with brain Abeta load. No evidence was found of risk for AD with these variants, nor of an effect on age at onset. However, an impact of IL-1B-(511) on Abeta(40) load (P < 0.05) was detected.

AB - Polymorphisms in the interleukin-1 genes, IL-1A and IL-1B, have been associated with AD, but not in all studies. The authors genotyped the IL-1A(-889) and IL-1B(-511) polymorphisms in large independent cohorts of 503 control individuals and 395 patients with AD, and a further 100 with brain Abeta load. No evidence was found of risk for AD with these variants, nor of an effect on age at onset. However, an impact of IL-1B-(511) on Abeta(40) load (P < 0.05) was detected.

KW - ALZHEIMERS-DISEASE

KW - SENILE PLAQUES

KW - ASSOCIATION

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JF - Neurology

SN - 0028-3878

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