Are multiple checkpoint mediators involved in a checkpoint linking histone gene expression with DNA replication?

B. Muller, J. Blackburn, C. Feijoo, Xiujie Zhao, C. Smythe

Research output: Contribution to journalLetter

6 Citations (Scopus)

Abstract

In metazoans, accurate replication of chromosomes is ensured by the coupling of DNA synthesis to the synthesis of histone proteins. Expression of replication-dependent histone genes is restricted to S-phase by a combination of cell cycle-regulated transcriptional and post-transcriptional control mechanisms and is linked to DNA replication by a poorly understood mechanism involving checkpoint kinases [Su, Gao, Schneider, Helt, Weiss, O'Reilly, Bohmann and Zhao (2004) EMBO J. 23, 1133–1143; Kaygun and Marzluff (2005) Nat. Struct. Mol. Biol. 12, 794–800]. Here we propose a model for the molecular mechanisms that link these two important processes within S-phase, and propose roles for multiple checkpoints in this mechanism.
Original languageEnglish
Pages (from-to)1369-1371
Number of pages3
JournalBiochemical Society Transactions
Volume35
Issue number5
DOIs
Publication statusPublished - 2007

Fingerprint

DNA Replication
S Phase
Gene expression
Histones
Gene Expression
Molecular Models
DNA
Chromosomes
Cell Cycle
Phosphotransferases
Genes
Cells
Proteins

Keywords

  • ataxia-telangiectasia mutated gene (ATM)
  • ataxia-telangiectasia and Rad3-related (ATR)
  • DNA-activated protein kinase
  • DNA replication
  • histone gene expression
  • human phosphatidylinositol 3-kinase-related kinase
  • RNA stability

Cite this

Are multiple checkpoint mediators involved in a checkpoint linking histone gene expression with DNA replication? / Muller, B.; Blackburn, J.; Feijoo, C.; Zhao, Xiujie; Smythe, C.

In: Biochemical Society Transactions, Vol. 35, No. 5, 2007, p. 1369-1371.

Research output: Contribution to journalLetter

Muller, B. ; Blackburn, J. ; Feijoo, C. ; Zhao, Xiujie ; Smythe, C. / Are multiple checkpoint mediators involved in a checkpoint linking histone gene expression with DNA replication?. In: Biochemical Society Transactions. 2007 ; Vol. 35, No. 5. pp. 1369-1371.
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T1 - Are multiple checkpoint mediators involved in a checkpoint linking histone gene expression with DNA replication?

AU - Muller, B.

AU - Blackburn, J.

AU - Feijoo, C.

AU - Zhao, Xiujie

AU - Smythe, C.

PY - 2007

Y1 - 2007

N2 - In metazoans, accurate replication of chromosomes is ensured by the coupling of DNA synthesis to the synthesis of histone proteins. Expression of replication-dependent histone genes is restricted to S-phase by a combination of cell cycle-regulated transcriptional and post-transcriptional control mechanisms and is linked to DNA replication by a poorly understood mechanism involving checkpoint kinases [Su, Gao, Schneider, Helt, Weiss, O'Reilly, Bohmann and Zhao (2004) EMBO J. 23, 1133–1143; Kaygun and Marzluff (2005) Nat. Struct. Mol. Biol. 12, 794–800]. Here we propose a model for the molecular mechanisms that link these two important processes within S-phase, and propose roles for multiple checkpoints in this mechanism.

AB - In metazoans, accurate replication of chromosomes is ensured by the coupling of DNA synthesis to the synthesis of histone proteins. Expression of replication-dependent histone genes is restricted to S-phase by a combination of cell cycle-regulated transcriptional and post-transcriptional control mechanisms and is linked to DNA replication by a poorly understood mechanism involving checkpoint kinases [Su, Gao, Schneider, Helt, Weiss, O'Reilly, Bohmann and Zhao (2004) EMBO J. 23, 1133–1143; Kaygun and Marzluff (2005) Nat. Struct. Mol. Biol. 12, 794–800]. Here we propose a model for the molecular mechanisms that link these two important processes within S-phase, and propose roles for multiple checkpoints in this mechanism.

KW - ataxia-telangiectasia mutated gene (ATM)

KW - ataxia-telangiectasia and Rad3-related (ATR)

KW - DNA-activated protein kinase

KW - DNA replication

KW - histone gene expression

KW - human phosphatidylinositol 3-kinase-related kinase

KW - RNA stability

U2 - 10.1042/BST0351369

DO - 10.1042/BST0351369

M3 - Letter

VL - 35

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EP - 1371

JO - Biochemical Society Transactions

JF - Biochemical Society Transactions

SN - 0300-5127

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