Are multiple checkpoint mediators involved in a checkpoint linking histone gene expression with DNA replication?

B. Muller, J. Blackburn, C. Feijoo, Xiujie Zhao, C. Smythe

Research output: Contribution to journalLetterpeer-review

6 Citations (Scopus)

Abstract

In metazoans, accurate replication of chromosomes is ensured by the coupling of DNA synthesis to the synthesis of histone proteins. Expression of replication-dependent histone genes is restricted to S-phase by a combination of cell cycle-regulated transcriptional and post-transcriptional control mechanisms and is linked to DNA replication by a poorly understood mechanism involving checkpoint kinases [Su, Gao, Schneider, Helt, Weiss, O'Reilly, Bohmann and Zhao (2004) EMBO J. 23, 1133–1143; Kaygun and Marzluff (2005) Nat. Struct. Mol. Biol. 12, 794–800]. Here we propose a model for the molecular mechanisms that link these two important processes within S-phase, and propose roles for multiple checkpoints in this mechanism.
Original languageEnglish
Pages (from-to)1369-1371
Number of pages3
JournalBiochemical Society Transactions
Volume35
Issue number5
DOIs
Publication statusPublished - 2007

Keywords

  • ataxia-telangiectasia mutated gene (ATM)
  • ataxia-telangiectasia and Rad3-related (ATR)
  • DNA-activated protein kinase
  • DNA replication
  • histone gene expression
  • human phosphatidylinositol 3-kinase-related kinase
  • RNA stability

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