Are pharmacological randomised controlled clinical trials relevant to real-life asthma populations?: A protocol for an UNLOCK study from the IPCRG

Karin Lisspers; Pedro Teixeira; Coert Blom; Janwillem Kocks; Björn Ställberg; David Price; Niels Chavannes

doi:10.1038/npjpcrm.2016.16

Are pharmacological randomised controlled clinical trials relevant to real-life asthma populations? A protocol for an UNLOCK study from the IPCRG

Karin Lisspers, Pedro Teixeira, Coert Blom, Janwillem Kocks, Björn Ställberg, David Price, Niels Chavannes

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

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Abstract

Asthma has a high prevalence worldwide with a high incidence in primary care settings in many countries. It is by definition a variable disease with a broad spectrum of clinical phenotypes, in which management and treatment can be difficult. The aim of asthma treatment is optimal control of the disease, which according to Global Initiative for Asthma (GINA) guidelines implies both symptom control and prevention of exacerbations. Despite several treatment options, studies show that about half of the patients have poor asthma control. When asthma is not controlled, it decreases the quality of life, increases the risk of exacerbations and premature death and is a high cost for the society.

Original language	English
Article number	16016
Pages (from-to)	1-3
Number of pages	3
Journal	npj Primary Care Respiratory Medicine
Volume	26
Early online date	14 Apr 2016
DOIs	https://doi.org/10.1038/npjpcrm.2016.16
Publication status	Published - 2016

Bibliographical note

Funding
The IPCRG provided funding for this research project as an UNLOCK Group study for which the funding was obtained through an unrestricted grant by Novartis AG, Basel, Switzerland. Novartis has no role in study design, data collection and analysis, decision to publish or preparation of the manuscript. This study will include data from the Optimum Patient Care Research Database and is undertaken in collaboration with Optimum Patient Care and the Respiratory Effectiveness Group.

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Are pharmacological randomised controlled clinical trials relevant to real-life asthma populations? A protocol for an UNLOCK study from the IPCRG
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Cite this

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title = "Are pharmacological randomised controlled clinical trials relevant to real-life asthma populations?: A protocol for an UNLOCK study from the IPCRG",

abstract = "Asthma has a high prevalence worldwide with a high incidence in primary care settings in many countries. It is by definition a variable disease with a broad spectrum of clinical phenotypes, in which management and treatment can be difficult. The aim of asthma treatment is optimal control of the disease, which according to Global Initiative for Asthma (GINA) guidelines implies both symptom control and prevention of exacerbations. Despite several treatment options, studies show that about half of the patients have poor asthma control. When asthma is not controlled, it decreases the quality of life, increases the risk of exacerbations and premature death and is a high cost for the society.",

author = "Karin Lisspers and Pedro Teixeira and Coert Blom and Janwillem Kocks and Bj{\"o}rn St{\"a}llberg and David Price and Niels Chavannes",

note = "Funding The IPCRG provided funding for this research project as an UNLOCK Group study for which the funding was obtained through an unrestricted grant by Novartis AG, Basel, Switzerland. Novartis has no role in study design, data collection and analysis, decision to publish or preparation of the manuscript. This study will include data from the Optimum Patient Care Research Database and is undertaken in collaboration with Optimum Patient Care and the Respiratory Effectiveness Group.",

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AU - Lisspers, Karin

AU - Teixeira, Pedro

AU - Blom, Coert

AU - Kocks, Janwillem

AU - Ställberg, Björn

AU - Price, David

AU - Chavannes, Niels

N1 - Funding The IPCRG provided funding for this research project as an UNLOCK Group study for which the funding was obtained through an unrestricted grant by Novartis AG, Basel, Switzerland. Novartis has no role in study design, data collection and analysis, decision to publish or preparation of the manuscript. This study will include data from the Optimum Patient Care Research Database and is undertaken in collaboration with Optimum Patient Care and the Respiratory Effectiveness Group.

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AB - Asthma has a high prevalence worldwide with a high incidence in primary care settings in many countries. It is by definition a variable disease with a broad spectrum of clinical phenotypes, in which management and treatment can be difficult. The aim of asthma treatment is optimal control of the disease, which according to Global Initiative for Asthma (GINA) guidelines implies both symptom control and prevention of exacerbations. Despite several treatment options, studies show that about half of the patients have poor asthma control. When asthma is not controlled, it decreases the quality of life, increases the risk of exacerbations and premature death and is a high cost for the society.

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DO - 10.1038/npjpcrm.2016.16

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ER -

Are pharmacological randomised controlled clinical trials relevant to real-life asthma populations? A protocol for an UNLOCK study from the IPCRG

Abstract

Bibliographical note

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