Are the fractal skeletons the explanation for the narrowing of arteries due to cell trapping in a disturbed blood flow?

Adriane B. Schelin, Gyoegy Karolyi, Alessandro P. S. de Moura, Nuala Booth, Celso Grebogi

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

We show that common circulatory diseases, such as stenoses and aneurysms, generate chaotic advection of blood particles. This phenomenon has major consequences on the way the biochemical particles behave. Chaotic advection leads to a peculiar filamentary particle distribution, which in turn creates a favorable environment for particle reactions. Furthermore, we argue that the enhanced stretching dynamics induced by chaos can lead to the activation of platelets, particles involved in the thrombus formation. In particular, we vary the size of both stenoses and aneurysms, and model them under resting and exercising conditions. We show that the filamentary particle distribution, governed by the fractal skeleton, depends on the size of the vessel wall irregularity, and investigate how it varies under resting or exercising conditions. (C) 2011 Elsevier Ltd. All rights reserved.

Original languageEnglish
Pages (from-to)276-281
Number of pages6
JournalComputers in Biology and Medicine
Volume42
Issue number3
Early online date30 Jul 2011
DOIs
Publication statusPublished - Mar 2012

Keywords

  • blood flow
  • cardiovascular system
  • chaos
  • nonlinear dynamics
  • chaotic advection
  • shear-stress
  • boundaries
  • activation
  • thrombosis
  • system
  • model

Fingerprint Dive into the research topics of 'Are the fractal skeletons the explanation for the narrowing of arteries due to cell trapping in a disturbed blood flow?'. Together they form a unique fingerprint.

  • Cite this