Are the fractal skeletons the explanation for the narrowing of arteries due to cell trapping in a disturbed blood flow?

Adriane B. Schelin, Gyoegy Karolyi, Alessandro P. S. de Moura, Nuala Booth, Celso Grebogi

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

We show that common circulatory diseases, such as stenoses and aneurysms, generate chaotic advection of blood particles. This phenomenon has major consequences on the way the biochemical particles behave. Chaotic advection leads to a peculiar filamentary particle distribution, which in turn creates a favorable environment for particle reactions. Furthermore, we argue that the enhanced stretching dynamics induced by chaos can lead to the activation of platelets, particles involved in the thrombus formation. In particular, we vary the size of both stenoses and aneurysms, and model them under resting and exercising conditions. We show that the filamentary particle distribution, governed by the fractal skeleton, depends on the size of the vessel wall irregularity, and investigate how it varies under resting or exercising conditions. (C) 2011 Elsevier Ltd. All rights reserved.

Original languageEnglish
Pages (from-to)276-281
Number of pages6
JournalComputers in Biology and Medicine
Volume42
Issue number3
Early online date30 Jul 2011
DOIs
Publication statusPublished - Mar 2012

Fingerprint

Fractals
Advection
Skeleton
Aneurysm
Pathologic Constriction
Blood
Arteries
Muscle Stretching Exercises
Platelet Activation
Platelets
Chaos theory
Stretching
Thrombosis
Chemical activation

Keywords

  • blood flow
  • cardiovascular system
  • chaos
  • nonlinear dynamics
  • chaotic advection
  • shear-stress
  • boundaries
  • activation
  • thrombosis
  • system
  • model

Cite this

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title = "Are the fractal skeletons the explanation for the narrowing of arteries due to cell trapping in a disturbed blood flow?",
abstract = "We show that common circulatory diseases, such as stenoses and aneurysms, generate chaotic advection of blood particles. This phenomenon has major consequences on the way the biochemical particles behave. Chaotic advection leads to a peculiar filamentary particle distribution, which in turn creates a favorable environment for particle reactions. Furthermore, we argue that the enhanced stretching dynamics induced by chaos can lead to the activation of platelets, particles involved in the thrombus formation. In particular, we vary the size of both stenoses and aneurysms, and model them under resting and exercising conditions. We show that the filamentary particle distribution, governed by the fractal skeleton, depends on the size of the vessel wall irregularity, and investigate how it varies under resting or exercising conditions. (C) 2011 Elsevier Ltd. All rights reserved.",
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author = "Schelin, {Adriane B.} and Gyoegy Karolyi and {de Moura}, {Alessandro P. S.} and Nuala Booth and Celso Grebogi",
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AU - Booth, Nuala

AU - Grebogi, Celso

N1 - A paid open access option is available for this journal. Voluntary deposit by author of pre-print allowed on Institutions open scholarly website and pre-print servers Voluntary deposit by author of authors post-print allowed on institutions open scholarly website including Institutional Repository Deposit due to Funding Body, Institutional and Governmental mandate only allowed where separate agreement between repository and publisher exists Set statement to accompany deposit Published source must be acknowledged Must link to journal home page or articles' DOI Publisher's version/PDF cannot be used Articles in some journals can be made Open Access on payment of additional charge NIH Authors articles will be submitted to PubMed Central after <num>12</num> <period units="month">months</period> Authors who are required to deposit in subject-based repositories may also use Sponsorship Option

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