Arginine Analogues Incorporating Carboxylate Bioisosteric Functions are Micromolar Inhibitors of Human Recombinant DDAH-1

Physics & Astronomy

• carboxylates 82%
• inhibitors 69%
• analogs 47%
• enzymes 42%
• metabolism 24%
• nitric oxide 24%
• interactions 15%
• synthesis 14%
• molecular dynamics 14%
• kinetics 11%
• molecules 10%
• simulation 7%

Medicine & Life Sciences

• dimethylargininase 97%
• Arginine 55%
• N,N-dimethylarginine 9%
• Molecular Dynamics Simulation 7%
• Enzymes 7%
• Nitric Oxide Synthase 6%
• Inhibitory Concentration 50 6%
• Catalytic Domain 6%
• Protein Isoforms 5%
• Kinetics 4%
• In Vitro Techniques 2%

Chemical Compounds

• Dimethylarginine 100%
• Arginine 59%
• Pharmacological Metabolism 4%
• Pharmacokinetics 4%
• Molecular Dynamics 4%
• Simulation 3%
• Molecule 2%