Arterial dysgenesis and limb defects: Clinical and experimental examples

Neil Vargesson; David R.  Hootnick

doi:10.1016/j.reprotox.2016.10.005

Arterial dysgenesis and limb defects: Clinical and experimental examples

Neil Vargesson, David R. Hootnick

Research output: Contribution to journal › Article › peer-review

21 Citations (Scopus)

8 Downloads (Pure)

Abstract

Limb malformations are amongst the most common and visible birth effects. Causes have been purported to include genetic aberrations as well as teratogens, such as thalidomide. Here we review the evidence for vascular disruption in the genesis of limb malformations through abnormal arterial transitioning and from events such as amniocentesis, uterine constriction, and through teratogen exposure. We use several clinical and experimental examples and highlight the need to understand more about the role the vascular system plays in the molecular mechanisms underpinning normal limb development.

Original language	English
Pages (from-to)	21-29
Number of pages	9
Journal	Reproductive Toxicology
Volume	70
Early online date	20 Oct 2016
DOIs	https://doi.org/10.1016/j.reprotox.2016.10.005
Publication status	Published - 1 Jun 2017

Keywords

vascular transition
thalidomide
Mifepristol
vascular disruption
human embryo
vertebrate embryo
clubfoot
vertical talus
PFFD (proximal femoral focal deficiency)
Holt-oram syndrome

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.reprotox.2016.10.005Licence: Unspecified

Accepted Manuscript
© 2016. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
Accepted author manuscript, 548 KBLicence: CC BY-NC-ND

Cite this

@article{968bed8b9c144ab786e24dae2ee0af9c,

title = "Arterial dysgenesis and limb defects: Clinical and experimental examples",

abstract = "Limb malformations are amongst the most common and visible birth effects. Causes have been purported to include genetic aberrations as well as teratogens, such as thalidomide. Here we review the evidence for vascular disruption in the genesis of limb malformations through abnormal arterial transitioning and from events such as amniocentesis, uterine constriction, and through teratogen exposure. We use several clinical and experimental examples and highlight the need to understand more about the role the vascular system plays in the molecular mechanisms underpinning normal limb development.",

keywords = "vascular transition, thalidomide, Mifepristol, vascular disruption, human embryo, vertebrate embryo, clubfoot, vertical talus, PFFD (proximal femoral focal deficiency), Holt-oram syndrome",

author = "Neil Vargesson and Hootnick, {David R.}",

note = "Acknowledgements This article is dedicated to Dr David S. Packard Jr. With thanks to Dr John DeSesso, Dr Lewis B. Holmes, Dr Mark Levinsohn, Dr David S. Packard Jr, Prof Lewis Wolpert for discussions on vascular disruption, particularly arterial dysgenesis and limb defects. We apologise to the many authors whose work we were unable to cite due to space limitations. This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.",

year = "2017",

month = jun,

day = "1",

doi = "10.1016/j.reprotox.2016.10.005",

language = "English",

volume = "70",

pages = "21--29",

journal = "Reproductive Toxicology",

issn = "0890-6238",

publisher = "Elsevier Inc.",

}

TY - JOUR

T1 - Arterial dysgenesis and limb defects

T2 - Clinical and experimental examples

AU - Vargesson, Neil

AU - Hootnick, David R.

N1 - Acknowledgements This article is dedicated to Dr David S. Packard Jr. With thanks to Dr John DeSesso, Dr Lewis B. Holmes, Dr Mark Levinsohn, Dr David S. Packard Jr, Prof Lewis Wolpert for discussions on vascular disruption, particularly arterial dysgenesis and limb defects. We apologise to the many authors whose work we were unable to cite due to space limitations. This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.

PY - 2017/6/1

Y1 - 2017/6/1

N2 - Limb malformations are amongst the most common and visible birth effects. Causes have been purported to include genetic aberrations as well as teratogens, such as thalidomide. Here we review the evidence for vascular disruption in the genesis of limb malformations through abnormal arterial transitioning and from events such as amniocentesis, uterine constriction, and through teratogen exposure. We use several clinical and experimental examples and highlight the need to understand more about the role the vascular system plays in the molecular mechanisms underpinning normal limb development.

AB - Limb malformations are amongst the most common and visible birth effects. Causes have been purported to include genetic aberrations as well as teratogens, such as thalidomide. Here we review the evidence for vascular disruption in the genesis of limb malformations through abnormal arterial transitioning and from events such as amniocentesis, uterine constriction, and through teratogen exposure. We use several clinical and experimental examples and highlight the need to understand more about the role the vascular system plays in the molecular mechanisms underpinning normal limb development.

KW - vascular transition

KW - thalidomide

KW - Mifepristol

KW - vascular disruption

KW - human embryo

KW - vertebrate embryo

KW - clubfoot

KW - vertical talus

KW - PFFD (proximal femoral focal deficiency)

KW - Holt-oram syndrome

U2 - 10.1016/j.reprotox.2016.10.005

DO - 10.1016/j.reprotox.2016.10.005

M3 - Article

C2 - 27773741

VL - 70

SP - 21

EP - 29

JO - Reproductive Toxicology

JF - Reproductive Toxicology

SN - 0890-6238

ER -

Arterial dysgenesis and limb defects: Clinical and experimental examples

Abstract

Keywords

UN SDGs

Access to Document

Fingerprint

Cite this