Aryl-phenyl-sulfonamide-phenylene compounds and their use

I R Greig (Inventor), J A Clase (Inventor), R Fisher (Inventor), R M Sheridan (Inventor), A Smith (Inventor), M J Tozer (Inventor), A R Tufnell (Inventor), R J van 't Hof (Inventor)

Research output: Patent

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Abstract

The present invention pertains generally to the field of therapeutic compounds, and more specifically to certain aryl-phenyl-sulfonamido-phenylene compounds of the following formula (I) (collectively referred to herein as "APSAP compounds"). The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, in treatment, for example, of inflammation and/or joint destruction and/or bone loss; of disorders mediated by excessive and/or inappropriate and/or prolonged activation of the immune system; of inflammatory and autoimmune disorders, for example, rheumatoid arthritis, psoriasis, psoriatic arthritis, chronic obstructive pulmonary disease (COPD), atherosclerosis, inflammatory bowel disease, ankylosing spondylitis, and the like; of disorders associated with bone loss, such as bone loss associated with excessive osteoclast activity in rheumatoid arthritis, osteoporosis, cancer-associated bone disease, Paget's disease and the like, etc.; and of cancer, such as a haematological malignancy, a solid tumour, etc.
Original languageEnglish
Patent numberWO2010/032010
IPCWO2010/032010
Publication statusPublished - 25 Mar 2010

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Sulfonamides
Bone and Bones
Rheumatoid Arthritis
Bone Neoplasms
Psoriatic Arthritis
Bone Diseases
Ankylosing Spondylitis
Osteoclasts
Hematologic Neoplasms
Inflammatory Bowel Diseases
Psoriasis
Chronic Obstructive Pulmonary Disease
Osteoporosis
Immune System
Neoplasms
Atherosclerosis
Joints
Inflammation
Pharmaceutical Preparations
Therapeutics

Cite this

Greig, I. R., Clase, J. A., Fisher, R., Sheridan, R. M., Smith, A., Tozer, M. J., ... van 't Hof, R. J. (2010). IPC No. WO2010/032010. Aryl-phenyl-sulfonamide-phenylene compounds and their use. (Patent No. WO2010/032010).

Aryl-phenyl-sulfonamide-phenylene compounds and their use. / Greig, I R (Inventor); Clase, J A (Inventor); Fisher, R (Inventor); Sheridan, R M (Inventor); Smith, A (Inventor); Tozer, M J (Inventor); Tufnell, A R (Inventor); van 't Hof, R J (Inventor).

IPC No.: WO2010/032010. Patent No.: WO2010/032010.

Research output: Patent

Greig, IR, Clase, JA, Fisher, R, Sheridan, RM, Smith, A, Tozer, MJ, Tufnell, AR & van 't Hof, RJ 2010, Aryl-phenyl-sulfonamide-phenylene compounds and their use, Patent No. WO2010/032010, IPC No. WO2010/032010.
Greig IR, Clase JA, Fisher R, Sheridan RM, Smith A, Tozer MJ et al, inventors. Aryl-phenyl-sulfonamide-phenylene compounds and their use. WO2010/032010. 2010 Mar 25.
Greig, I R (Inventor) ; Clase, J A (Inventor) ; Fisher, R (Inventor) ; Sheridan, R M (Inventor) ; Smith, A (Inventor) ; Tozer, M J (Inventor) ; Tufnell, A R (Inventor) ; van 't Hof, R J (Inventor). / Aryl-phenyl-sulfonamide-phenylene compounds and their use. IPC No.: WO2010/032010. Patent No.: WO2010/032010.
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N2 - The present invention pertains generally to the field of therapeutic compounds, and more specifically to certain aryl-phenyl-sulfonamido-phenylene compounds of the following formula (I) (collectively referred to herein as "APSAP compounds"). The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, in treatment, for example, of inflammation and/or joint destruction and/or bone loss; of disorders mediated by excessive and/or inappropriate and/or prolonged activation of the immune system; of inflammatory and autoimmune disorders, for example, rheumatoid arthritis, psoriasis, psoriatic arthritis, chronic obstructive pulmonary disease (COPD), atherosclerosis, inflammatory bowel disease, ankylosing spondylitis, and the like; of disorders associated with bone loss, such as bone loss associated with excessive osteoclast activity in rheumatoid arthritis, osteoporosis, cancer-associated bone disease, Paget's disease and the like, etc.; and of cancer, such as a haematological malignancy, a solid tumour, etc.

AB - The present invention pertains generally to the field of therapeutic compounds, and more specifically to certain aryl-phenyl-sulfonamido-phenylene compounds of the following formula (I) (collectively referred to herein as "APSAP compounds"). The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, in treatment, for example, of inflammation and/or joint destruction and/or bone loss; of disorders mediated by excessive and/or inappropriate and/or prolonged activation of the immune system; of inflammatory and autoimmune disorders, for example, rheumatoid arthritis, psoriasis, psoriatic arthritis, chronic obstructive pulmonary disease (COPD), atherosclerosis, inflammatory bowel disease, ankylosing spondylitis, and the like; of disorders associated with bone loss, such as bone loss associated with excessive osteoclast activity in rheumatoid arthritis, osteoporosis, cancer-associated bone disease, Paget's disease and the like, etc.; and of cancer, such as a haematological malignancy, a solid tumour, etc.

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