Aryl-Phenyl-Sulfonamido-Cycloalkyl Compounds and Their Use

Iain Robert Greig (Inventor), Rose Mary Sheridan (Inventor), Raymond Fisher (Inventor), Matthew John Tozer (Inventor), Juha Andrew Clase (Inventor), Andrew Smith (Inventor), Andrew Robert Tufnell (Inventor), Robert Jurgen van 't Hof (Inventor)

Research output: Patent

Abstract

The present invention pertains generally to the field of therapeutic compounds, and more specifically to certain aryl-phenyl-sulfonamido-cycloalkyl compounds of the following formula (collectively referred to herein as “APSAC compounds”). The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, in treatment, for example, of inflammation and/or joint destruction and/or bone loss; of disorders mediated by excessive and/or inappropriate and/or prolonged activation of the immune system; of inflammatory and autoimmune disorders, for example, rheumatoid arthritis, psoriasis, psoriatic arthritis, chronic obstructive pulmonary disease (COPD), atherosclerosis, inflammatory bowel disease, ankylosing spondylitis, and the like; of disorders associated with bone loss, such as bone loss associated with excessive osteoclast activity in rheumatoid arthritis, osteoporosis, cancer-associated bone disease, Paget's disease and the like, etc.; and of cancer, such as a haematological malignancy, a solid tumour, etc.
Original languageEnglish
Patent numberUS2013245018
Publication statusPublished - 19 Sep 2013

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Bone and Bones
Rheumatoid Arthritis
Anistreplase
Bone Neoplasms
Psoriatic Arthritis
Bone Diseases
Ankylosing Spondylitis
Osteoclasts
Hematologic Neoplasms
Inflammatory Bowel Diseases
Psoriasis
Chronic Obstructive Pulmonary Disease
Osteoporosis
Immune System
Neoplasms
Atherosclerosis
Joints
Inflammation
Pharmaceutical Preparations
Therapeutics

Cite this

Greig, I. R., Sheridan, R. M., Fisher, R., Tozer, M. J., Clase, J. A., Smith, A., ... van 't Hof, R. J. (2013). Aryl-Phenyl-Sulfonamido-Cycloalkyl Compounds and Their Use. (Patent No. US2013245018).

Aryl-Phenyl-Sulfonamido-Cycloalkyl Compounds and Their Use. / Greig, Iain Robert (Inventor); Sheridan, Rose Mary (Inventor); Fisher, Raymond (Inventor); Tozer, Matthew John (Inventor); Clase, Juha Andrew (Inventor); Smith, Andrew (Inventor); Tufnell, Andrew Robert (Inventor); van 't Hof, Robert Jurgen (Inventor).

Patent No.: US2013245018.

Research output: Patent

Greig, IR, Sheridan, RM, Fisher, R, Tozer, MJ, Clase, JA, Smith, A, Tufnell, AR & van 't Hof, RJ 2013, Aryl-Phenyl-Sulfonamido-Cycloalkyl Compounds and Their Use, Patent No. US2013245018.
Greig IR, Sheridan RM, Fisher R, Tozer MJ, Clase JA, Smith A et al, inventors. Aryl-Phenyl-Sulfonamido-Cycloalkyl Compounds and Their Use. US2013245018. 2013 Sep 19.
Greig, Iain Robert (Inventor) ; Sheridan, Rose Mary (Inventor) ; Fisher, Raymond (Inventor) ; Tozer, Matthew John (Inventor) ; Clase, Juha Andrew (Inventor) ; Smith, Andrew (Inventor) ; Tufnell, Andrew Robert (Inventor) ; van 't Hof, Robert Jurgen (Inventor). / Aryl-Phenyl-Sulfonamido-Cycloalkyl Compounds and Their Use. Patent No.: US2013245018.
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N2 - The present invention pertains generally to the field of therapeutic compounds, and more specifically to certain aryl-phenyl-sulfonamido-cycloalkyl compounds of the following formula (collectively referred to herein as “APSAC compounds”). The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, in treatment, for example, of inflammation and/or joint destruction and/or bone loss; of disorders mediated by excessive and/or inappropriate and/or prolonged activation of the immune system; of inflammatory and autoimmune disorders, for example, rheumatoid arthritis, psoriasis, psoriatic arthritis, chronic obstructive pulmonary disease (COPD), atherosclerosis, inflammatory bowel disease, ankylosing spondylitis, and the like; of disorders associated with bone loss, such as bone loss associated with excessive osteoclast activity in rheumatoid arthritis, osteoporosis, cancer-associated bone disease, Paget's disease and the like, etc.; and of cancer, such as a haematological malignancy, a solid tumour, etc.

AB - The present invention pertains generally to the field of therapeutic compounds, and more specifically to certain aryl-phenyl-sulfonamido-cycloalkyl compounds of the following formula (collectively referred to herein as “APSAC compounds”). The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, in treatment, for example, of inflammation and/or joint destruction and/or bone loss; of disorders mediated by excessive and/or inappropriate and/or prolonged activation of the immune system; of inflammatory and autoimmune disorders, for example, rheumatoid arthritis, psoriasis, psoriatic arthritis, chronic obstructive pulmonary disease (COPD), atherosclerosis, inflammatory bowel disease, ankylosing spondylitis, and the like; of disorders associated with bone loss, such as bone loss associated with excessive osteoclast activity in rheumatoid arthritis, osteoporosis, cancer-associated bone disease, Paget's disease and the like, etc.; and of cancer, such as a haematological malignancy, a solid tumour, etc.

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