Abstract
Original language | English |
---|---|
Pages (from-to) | 187-192 |
Number of pages | 6 |
Journal | Journal of Medical Genetics |
Volume | 33 |
Issue number | 3 |
Publication status | Published - 1 Mar 1996 |
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Keywords
- Adult
- Breast Neoplasms
- Family
- Female
- Genes, Dominant
- Genetic Counseling
- Great Britain
- Humans
- Linkage (Genetics)
- Male
- Medical History Taking
- Neoplasms
- Ovarian Neoplasms
- Ovariectomy
- Pedigree
- Risk Assessment
- Scotland
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Ascertainment of familial ovarian cancer in the Aberdeen Genetic Clinic. / Gregory, H.; Schofield, Andrew Craig; de Silva, D; Semper, J; Milner, Benedict J; Allan, L; Haites, Neva Elizabeth.
In: Journal of Medical Genetics, Vol. 33, No. 3, 01.03.1996, p. 187-192.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Ascertainment of familial ovarian cancer in the Aberdeen Genetic Clinic
AU - Gregory, H.
AU - Schofield, Andrew Craig
AU - de Silva, D
AU - Semper, J
AU - Milner, Benedict J
AU - Allan, L
AU - Haites, Neva Elizabeth
PY - 1996/3/1
Y1 - 1996/3/1
N2 - Ovarian cancer is the fifth most common malignancy in women in the UK. Patients with a family history including ovarian cancer make up nearly 15% of family cancer referrals to the Genetic Clinic in Aberdeen. To date, only one pedigree has been suitable for linkage studies, which has enabled us to target screening more accurately at those people at highest risk. Following discovery of a strong candidate for the BRCA1 gene, direct mutation testing may soon be possible. People who seek testing will require further counselling. Therefore we anticipate an increased demand on both clinical and laboratory resources, but more accurate ascertainment of high risk subjects should lead to more appropriate targeting of screening services.
AB - Ovarian cancer is the fifth most common malignancy in women in the UK. Patients with a family history including ovarian cancer make up nearly 15% of family cancer referrals to the Genetic Clinic in Aberdeen. To date, only one pedigree has been suitable for linkage studies, which has enabled us to target screening more accurately at those people at highest risk. Following discovery of a strong candidate for the BRCA1 gene, direct mutation testing may soon be possible. People who seek testing will require further counselling. Therefore we anticipate an increased demand on both clinical and laboratory resources, but more accurate ascertainment of high risk subjects should lead to more appropriate targeting of screening services.
KW - Adult
KW - Breast Neoplasms
KW - Family
KW - Female
KW - Genes, Dominant
KW - Genetic Counseling
KW - Great Britain
KW - Humans
KW - Linkage (Genetics)
KW - Male
KW - Medical History Taking
KW - Neoplasms
KW - Ovarian Neoplasms
KW - Ovariectomy
KW - Pedigree
KW - Risk Assessment
KW - Scotland
M3 - Article
VL - 33
SP - 187
EP - 192
JO - Journal of Medical Genetics
JF - Journal of Medical Genetics
SN - 0022-2593
IS - 3
ER -