Ascertainment of familial ovarian cancer in the Aberdeen Genetic Clinic

H. Gregory, Andrew Craig Schofield, D de Silva, J Semper, Benedict J Milner, L Allan, Neva Elizabeth Haites

Research output: Contribution to journal › Article

1 Citation (Scopus)

Abstract

Ovarian cancer is the fifth most common malignancy in women in the UK. Patients with a family history including ovarian cancer make up nearly 15% of family cancer referrals to the Genetic Clinic in Aberdeen. To date, only one pedigree has been suitable for linkage studies, which has enabled us to target screening more accurately at those people at highest risk. Following discovery of a strong candidate for the BRCA1 gene, direct mutation testing may soon be possible. People who seek testing will require further counselling. Therefore we anticipate an increased demand on both clinical and laboratory resources, but more accurate ascertainment of high risk subjects should lead to more appropriate targeting of screening services.
Original languageEnglish
Pages (from-to)187-192
Number of pages6
JournalJournal of Medical Genetics
Volume33
Issue number3
Publication statusPublished - 1 Mar 1996

Fingerprint

Ovarian Neoplasms
BRCA1 Gene
Pedigree
Counseling
Neoplasms
Referral and Consultation
Mutation

Keywords

  • Adult
  • Breast Neoplasms
  • Family
  • Female
  • Genes, Dominant
  • Genetic Counseling
  • Great Britain
  • Humans
  • Linkage (Genetics)
  • Male
  • Medical History Taking
  • Neoplasms
  • Ovarian Neoplasms
  • Ovariectomy
  • Pedigree
  • Risk Assessment
  • Scotland

Cite this

Gregory, H., Schofield, A. C., de Silva, D., Semper, J., Milner, B. J., Allan, L., & Haites, N. E. (1996). Ascertainment of familial ovarian cancer in the Aberdeen Genetic Clinic. Journal of Medical Genetics, 33(3), 187-192.

Ascertainment of familial ovarian cancer in the Aberdeen Genetic Clinic. / Gregory, H.; Schofield, Andrew Craig; de Silva, D; Semper, J; Milner, Benedict J; Allan, L; Haites, Neva Elizabeth.

In: Journal of Medical Genetics, Vol. 33, No. 3, 01.03.1996, p. 187-192.

Research output: Contribution to journal › Article

Gregory, H, Schofield, AC, de Silva, D, Semper, J, Milner, BJ, Allan, L & Haites, NE 1996, 'Ascertainment of familial ovarian cancer in the Aberdeen Genetic Clinic', Journal of Medical Genetics, vol. 33, no. 3, pp. 187-192.
Gregory H, Schofield AC, de Silva D, Semper J, Milner BJ, Allan L et al. Ascertainment of familial ovarian cancer in the Aberdeen Genetic Clinic. Journal of Medical Genetics. 1996 Mar 1;33(3):187-192.
Gregory, H. ; Schofield, Andrew Craig ; de Silva, D ; Semper, J ; Milner, Benedict J ; Allan, L ; Haites, Neva Elizabeth. / Ascertainment of familial ovarian cancer in the Aberdeen Genetic Clinic. In: Journal of Medical Genetics. 1996 ; Vol. 33, No. 3. pp. 187-192.
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