Asenjonamides A-C, antibacterial metabolites isolated from Streptomyces asenjonii strain KNN 42.f from an extreme-hyper arid Atacama Desert soil

Mohamed S A Abdelkader, Thomas Philippon, Juan A Asenjo, Alan T Bull, Michael Goodfellow, Rainer Ebel, Marcel Jaspars, Mostafa E Rateb

Research output: Contribution to journalArticle

7 Citations (Scopus)
7 Downloads (Pure)

Abstract

Bio-guided fractionation of the culture broth extract of Streptomyces asenjonii strain KNN 42.f recovered from an extreme hyper-arid Atacama Desert soil in northern Chile led to the isolation of three new bioactive β-diketones; asenjonamides A-C (1-3) in addition to the known N-(2-(1H-indol-3-yl)-2-oxoethyl)acetamide (4), a series of bioactive acylated 4-aminoheptosyl-β-N-glycosides; spicamycins A-E (5-9), and seven known diketopiperazines (10-16). All isolated compounds were characterized by HRESIMS and NMR analyses and tested for their antibacterial effect against a panel of bacteria.

Original languageEnglish
Pages (from-to)425-431
Number of pages7
JournalThe Journal of antibiotics
Volume71
Early online date23 Jan 2018
DOIs
Publication statusPublished - 2018

Fingerprint

Diketopiperazines
Chile
Streptomyces
Glycosides
Soil
Bacteria
acetamide
septacidin

Keywords

  • Journal Article
  • Asenjonamides A–C
  • anti-bacterial
  • β-diketone
  • spicamycins
  • Streptomyces asenjonii
  • Atacama Desert

Cite this

Asenjonamides A-C, antibacterial metabolites isolated from Streptomyces asenjonii strain KNN 42.f from an extreme-hyper arid Atacama Desert soil. / Abdelkader, Mohamed S A; Philippon, Thomas; Asenjo, Juan A; Bull, Alan T; Goodfellow, Michael; Ebel, Rainer; Jaspars, Marcel; Rateb, Mostafa E.

In: The Journal of antibiotics, Vol. 71, 2018, p. 425-431.

Research output: Contribution to journalArticle

Abdelkader, Mohamed S A ; Philippon, Thomas ; Asenjo, Juan A ; Bull, Alan T ; Goodfellow, Michael ; Ebel, Rainer ; Jaspars, Marcel ; Rateb, Mostafa E. / Asenjonamides A-C, antibacterial metabolites isolated from Streptomyces asenjonii strain KNN 42.f from an extreme-hyper arid Atacama Desert soil. In: The Journal of antibiotics. 2018 ; Vol. 71. pp. 425-431.
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abstract = "Bio-guided fractionation of the culture broth extract of Streptomyces asenjonii strain KNN 42.f recovered from an extreme hyper-arid Atacama Desert soil in northern Chile led to the isolation of three new bioactive β-diketones; asenjonamides A-C (1-3) in addition to the known N-(2-(1H-indol-3-yl)-2-oxoethyl)acetamide (4), a series of bioactive acylated 4-aminoheptosyl-β-N-glycosides; spicamycins A-E (5-9), and seven known diketopiperazines (10-16). All isolated compounds were characterized by HRESIMS and NMR analyses and tested for their antibacterial effect against a panel of bacteria.",
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note = "We thank the College of Physical Sciences, University of Aberdeen, for provision of infrastructure and facilities in the Marine Biodiscovery Centre. This work was supported financially by the Biotechnological and Biological Sciences Research Council under the RCUK-CONICYT Newton International Research Project (JIC: CA586) and the Basal Programme of CONICYT for funding of the Centre for Biotechnology and Bioengineering, CeBiB (project FB0001).",
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AU - Abdelkader, Mohamed S A

AU - Philippon, Thomas

AU - Asenjo, Juan A

AU - Bull, Alan T

AU - Goodfellow, Michael

AU - Ebel, Rainer

AU - Jaspars, Marcel

AU - Rateb, Mostafa E

N1 - We thank the College of Physical Sciences, University of Aberdeen, for provision of infrastructure and facilities in the Marine Biodiscovery Centre. This work was supported financially by the Biotechnological and Biological Sciences Research Council under the RCUK-CONICYT Newton International Research Project (JIC: CA586) and the Basal Programme of CONICYT for funding of the Centre for Biotechnology and Bioengineering, CeBiB (project FB0001).

PY - 2018

Y1 - 2018

N2 - Bio-guided fractionation of the culture broth extract of Streptomyces asenjonii strain KNN 42.f recovered from an extreme hyper-arid Atacama Desert soil in northern Chile led to the isolation of three new bioactive β-diketones; asenjonamides A-C (1-3) in addition to the known N-(2-(1H-indol-3-yl)-2-oxoethyl)acetamide (4), a series of bioactive acylated 4-aminoheptosyl-β-N-glycosides; spicamycins A-E (5-9), and seven known diketopiperazines (10-16). All isolated compounds were characterized by HRESIMS and NMR analyses and tested for their antibacterial effect against a panel of bacteria.

AB - Bio-guided fractionation of the culture broth extract of Streptomyces asenjonii strain KNN 42.f recovered from an extreme hyper-arid Atacama Desert soil in northern Chile led to the isolation of three new bioactive β-diketones; asenjonamides A-C (1-3) in addition to the known N-(2-(1H-indol-3-yl)-2-oxoethyl)acetamide (4), a series of bioactive acylated 4-aminoheptosyl-β-N-glycosides; spicamycins A-E (5-9), and seven known diketopiperazines (10-16). All isolated compounds were characterized by HRESIMS and NMR analyses and tested for their antibacterial effect against a panel of bacteria.

KW - Journal Article

KW - Asenjonamides A–C

KW - anti-bacterial

KW - β-diketone

KW - spicamycins

KW - Streptomyces asenjonii

KW - Atacama Desert

U2 - 10.1038/s41429-017-0012-0

DO - 10.1038/s41429-017-0012-0

M3 - Article

VL - 71

SP - 425

EP - 431

JO - The Journal of antibiotics

JF - The Journal of antibiotics

SN - 0021-8820

ER -