Asenjonamides A-C, antibacterial metabolites isolated from Streptomyces asenjonii strain KNN 42.f from an extreme-hyper arid Atacama Desert soil

Mohamed S A Abdelkader; Thomas Philippon; Juan A Asenjo; Alan T Bull; Michael Goodfellow; Rainer Ebel; Marcel Jaspars; Mostafa E Rateb

doi:10.1038/s41429-017-0012-0

Asenjonamides A-C, antibacterial metabolites isolated from Streptomyces asenjonii strain KNN 42.f from an extreme-hyper arid Atacama Desert soil

Mohamed S A Abdelkader, Thomas Philippon, Juan A Asenjo, Alan T Bull, Michael Goodfellow, Rainer Ebel, Marcel Jaspars, Mostafa E Rateb

Chemistry

Research output: Contribution to journal › Article › peer-review

35 Citations (Scopus)

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Abstract

Bio-guided fractionation of the culture broth extract of Streptomyces asenjonii strain KNN 42.f recovered from an extreme hyper-arid Atacama Desert soil in northern Chile led to the isolation of three new bioactive β-diketones; asenjonamides A-C (1-3) in addition to the known N-(2-(1H-indol-3-yl)-2-oxoethyl)acetamide (4), a series of bioactive acylated 4-aminoheptosyl-β-N-glycosides; spicamycins A-E (5-9), and seven known diketopiperazines (10-16). All isolated compounds were characterized by HRESIMS and NMR analyses and tested for their antibacterial effect against a panel of bacteria.

Original language	English
Pages (from-to)	425-431
Number of pages	7
Journal	The Journal of antibiotics
Volume	71
Early online date	23 Jan 2018
DOIs	https://doi.org/10.1038/s41429-017-0012-0
Publication status	Published - 2018

Bibliographical note

We thank the College of Physical Sciences, University of Aberdeen, for provision of infrastructure and facilities in the Marine Biodiscovery Centre. This work was supported financially by the Biotechnological and Biological Sciences Research Council under the RCUK-CONICYT Newton International Research Project (JIC: CA586) and the Basal Programme of CONICYT for funding of the Centre for Biotechnology and Bioengineering, CeBiB (project FB0001).

Keywords

Journal Article
Asenjonamides A–C
anti-bacterial
β-diketone
spicamycins
Streptomyces asenjonii
Atacama Desert

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Accepted ManuscriptAccepted author manuscript, 200 KBLicence: Other

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title = "Asenjonamides A-C, antibacterial metabolites isolated from Streptomyces asenjonii strain KNN 42.f from an extreme-hyper arid Atacama Desert soil",

abstract = "Bio-guided fractionation of the culture broth extract of Streptomyces asenjonii strain KNN 42.f recovered from an extreme hyper-arid Atacama Desert soil in northern Chile led to the isolation of three new bioactive β-diketones; asenjonamides A-C (1-3) in addition to the known N-(2-(1H-indol-3-yl)-2-oxoethyl)acetamide (4), a series of bioactive acylated 4-aminoheptosyl-β-N-glycosides; spicamycins A-E (5-9), and seven known diketopiperazines (10-16). All isolated compounds were characterized by HRESIMS and NMR analyses and tested for their antibacterial effect against a panel of bacteria.",

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note = "We thank the College of Physical Sciences, University of Aberdeen, for provision of infrastructure and facilities in the Marine Biodiscovery Centre. This work was supported financially by the Biotechnological and Biological Sciences Research Council under the RCUK-CONICYT Newton International Research Project (JIC: CA586) and the Basal Programme of CONICYT for funding of the Centre for Biotechnology and Bioengineering, CeBiB (project FB0001).",

year = "2018",

doi = "10.1038/s41429-017-0012-0",

language = "English",

volume = "71",

pages = "425--431",

journal = "The Journal of antibiotics",

issn = "0021-8820",

publisher = "Japan Antibiotics Research Association",

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TY - JOUR

T1 - Asenjonamides A-C, antibacterial metabolites isolated from Streptomyces asenjonii strain KNN 42.f from an extreme-hyper arid Atacama Desert soil

AU - Abdelkader, Mohamed S A

AU - Philippon, Thomas

AU - Asenjo, Juan A

AU - Bull, Alan T

AU - Goodfellow, Michael

AU - Ebel, Rainer

AU - Jaspars, Marcel

AU - Rateb, Mostafa E

N1 - We thank the College of Physical Sciences, University of Aberdeen, for provision of infrastructure and facilities in the Marine Biodiscovery Centre. This work was supported financially by the Biotechnological and Biological Sciences Research Council under the RCUK-CONICYT Newton International Research Project (JIC: CA586) and the Basal Programme of CONICYT for funding of the Centre for Biotechnology and Bioengineering, CeBiB (project FB0001).

PY - 2018

Y1 - 2018

N2 - Bio-guided fractionation of the culture broth extract of Streptomyces asenjonii strain KNN 42.f recovered from an extreme hyper-arid Atacama Desert soil in northern Chile led to the isolation of three new bioactive β-diketones; asenjonamides A-C (1-3) in addition to the known N-(2-(1H-indol-3-yl)-2-oxoethyl)acetamide (4), a series of bioactive acylated 4-aminoheptosyl-β-N-glycosides; spicamycins A-E (5-9), and seven known diketopiperazines (10-16). All isolated compounds were characterized by HRESIMS and NMR analyses and tested for their antibacterial effect against a panel of bacteria.

AB - Bio-guided fractionation of the culture broth extract of Streptomyces asenjonii strain KNN 42.f recovered from an extreme hyper-arid Atacama Desert soil in northern Chile led to the isolation of three new bioactive β-diketones; asenjonamides A-C (1-3) in addition to the known N-(2-(1H-indol-3-yl)-2-oxoethyl)acetamide (4), a series of bioactive acylated 4-aminoheptosyl-β-N-glycosides; spicamycins A-E (5-9), and seven known diketopiperazines (10-16). All isolated compounds were characterized by HRESIMS and NMR analyses and tested for their antibacterial effect against a panel of bacteria.

KW - Journal Article

KW - Asenjonamides A–C

KW - anti-bacterial

KW - β-diketone

KW - spicamycins

KW - Streptomyces asenjonii

KW - Atacama Desert

U2 - 10.1038/s41429-017-0012-0

DO - 10.1038/s41429-017-0012-0

M3 - Article

C2 - 29362461

SN - 0021-8820

VL - 71

SP - 425

EP - 431

JO - The Journal of antibiotics

JF - The Journal of antibiotics

ER -

Asenjonamides A-C, antibacterial metabolites isolated from Streptomyces asenjonii strain KNN 42.f from an extreme-hyper arid Atacama Desert soil

Abstract

Bibliographical note

Keywords

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