Asenjonamides A-C, antibacterial metabolites isolated from Streptomyces asenjonii strain KNN 42.f from an extreme-hyper arid Atacama Desert soil

Mohamed S A Abdelkader, Thomas Philippon, Juan A Asenjo, Alan T Bull, Michael Goodfellow, Rainer Ebel, Marcel Jaspars, Mostafa E Rateb

Research output: Contribution to journalArticle

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Abstract

Bio-guided fractionation of the culture broth extract of Streptomyces asenjonii strain KNN 42.f recovered from an extreme hyper-arid Atacama Desert soil in northern Chile led to the isolation of three new bioactive β-diketones; asenjonamides A-C (1-3) in addition to the known N-(2-(1H-indol-3-yl)-2-oxoethyl)acetamide (4), a series of bioactive acylated 4-aminoheptosyl-β-N-glycosides; spicamycins A-E (5-9), and seven known diketopiperazines (10-16). All isolated compounds were characterized by HRESIMS and NMR analyses and tested for their antibacterial effect against a panel of bacteria.

Original languageEnglish
Pages (from-to)425-431
Number of pages7
JournalThe Journal of antibiotics
Volume71
Early online date23 Jan 2018
DOIs
Publication statusPublished - 2018

Keywords

  • Journal Article
  • Asenjonamides A–C
  • anti-bacterial
  • β-diketone
  • spicamycins
  • Streptomyces asenjonii
  • Atacama Desert

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