Aspirin dilemma. Remodelling the hypothesis from a fertility perspective

O. Ozturk, Michael Greaves, Alexander Allan Templeton

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Many clinical trials in obstetrics have failed to demonstrate improved outcomes with low-dose aspirin. This is not entirely surprising as prescribing aspirin for compromised tissue perfusion without insight into underlying pathology inevitably leads to suboptimal outcomes. We argue that a mismatch between the aspirin dose and the underlying pathology of altered tissue perfusion is the key factor to this failure. Based on this groundwork, we address the question of how best to optimize the dose of aspirin for use in fertility management, by providing examples from the assisted conception and recurrent miscarriage settings.

Original languageEnglish
Pages (from-to)1146-1148
Number of pages2
JournalHuman Reproduction
Volume17
Issue number5
DOIs
Publication statusPublished - 2002

Keywords

  • aspirin
  • fertility
  • IVF
  • miscarriages
  • prostaglandins
  • IN-VITRO FERTILIZATION
  • LOW-DOSE ASPIRIN
  • ANTIPHOSPHOLIPID ANTIBODIES
  • EMBRYO-TRANSFER
  • RECURRENT MISCARRIAGE
  • PREGNANCY RATES
  • PROSTAGLANDIN ENDOPEROXIDES
  • AUTOIMMUNE ANTIBODIES
  • INVITRO FERTILIZATION
  • UTERINE PERFUSION

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