Assessing the environmental performance of NADH regeneration methods: a cleaner process using recyclable Pt/Fe3O4 and hydrogen

Tony Saba, Joseph W. H. Burnett, Jianwei Li, Xiaonan Wang, James A. Anderson, Panagiotis N. Kechagiopoulos, Xiaodong Wang (Corresponding Author)

Research output: Contribution to journalArticle

Abstract

Cofactor (reduced) Nicotinamide Adenine Dinucleotide (NAD(P)H) is an energy carrier in enzymatic redox reactions that are employed for the synthesis of valuable chemicals and pharmaceuticals. The high cost of NAD(P)H makes it impractical to use in stoichiometric amounts in industrial processes. This has led to the development of a variety of methods for NAD(P)H regeneration. In this work, process cleanliness of the current NADH recycling systems was evaluated using E-factor (kgwaste/kgNADH) as a green chemistry metric. The E-factor obtained, depending on the process method, reaches values higher than 20000, where non-recyclable agents, including sacrificial hydride/electron donors, catalysts and electron mediators, alongside by-products (from cosubstrates), account for the overall waste. A promising alternative methodology for NADH regeneration using H2 and recyclable Pt/Fe3O4 is presented and characterisation performed by temperature-programmed reduction (TPR), nitrogen adsorption (surface area/porosity), powder X-ray diffraction (XRD) and transmission electron microscopy (TEM) is used to elucidate observed performance. The Pt/Fe3O4 system at room temperature delivers a turnover frequency of 20 h-1 and the catalyst can be recycled for reuse, producing a significantly low level of waste (E-factor = ˜1).
Original languageEnglish
JournalCatalysis Today
Early online date21 Jan 2019
DOIs
Publication statusE-pub ahead of print - 21 Jan 2019

Fingerprint

NAD
Hydrogen
Catalysts
Electrons
Redox reactions
Hydrides
X ray powder diffraction
Drug products
Byproducts
Recycling
Porosity
Transmission electron microscopy
Nitrogen
Adsorption
Temperature
Costs
Pharmaceutical Preparations

Keywords

  • Cofactor NADH regeneration
  • E-factor
  • Heterogeneous catalysis
  • Hydrogen
  • Pt/Fe O

ASJC Scopus subject areas

  • Chemistry(all)
  • Catalysis

Cite this

Assessing the environmental performance of NADH regeneration methods : a cleaner process using recyclable Pt/Fe3O4 and hydrogen. / Saba, Tony; Burnett, Joseph W. H.; Li, Jianwei; Wang, Xiaonan; Anderson, James A.; Kechagiopoulos, Panagiotis N.; Wang, Xiaodong (Corresponding Author).

In: Catalysis Today, 21.01.2019.

Research output: Contribution to journalArticle

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