Assessment of the Teratogenic Effect of Drugs on the Chicken Embryo

Lucas Rosa Fraga; Maikel Rosa  de Oliveira; Karina Maria  Wermann; Neil Vargesson

doi:10.1007/978-1-0716-3625-1_12

Assessment of the Teratogenic Effect of Drugs on the Chicken Embryo

Lucas Rosa Fraga^* (Corresponding Author), Maikel Rosa de Oliveira, Karina Maria Wermann, Neil Vargesson

^*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceeding › Chapter

1 Citation (Scopus)

Abstract

Pre-clinical trials are an essential step that underpins the drug discovery, development and safety process. During this process, animal testing is performed to determine the safety of new compounds and any potential adverse effects. Developmental toxicity tests are carried out to verify whether the drug has potential to cause congenital anomalies to the developing embryo/foetus. Chicken embryos are very useful for these purposes and present several advantages, such as low cost of production and housing, easy handling and manipulation, rapid development in addition to sharing similarities to the human embryo at molecular, cellular, and anatomical levels. In this chapter, we bring methods for using the chicken embryo model for testing the teratogenic effects of drugs and assessing the main outcomes of them.

Original language	English
Title of host publication	Teratogenicity Testing
Subtitle of host publication	Methods and Protocols
Publisher	Springer
Chapter	12
Pages	251-260
Number of pages	10
Volume	2753
Edition	2
ISBN (Electronic)	978-1-0716-3625-1
ISBN (Print)	978-1-0716-3624-4
DOIs	https://doi.org/10.1007/978-1-0716-3625-1_12
Publication status	Published - 30 Jan 2024

Publication series

Name	Methods in Molecular Biology
Publisher	Humana NY
ISSN (Print)	1064-3745
ISSN (Electronic)	1940-6029

Bibliographical note

Acknowledgements
Fraga’s Lab is funded by Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul (FAPERGS), Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) and Fundo de Incentivo à Pesquisa e Eventos (FIPE) of the Hospital de Clínicas de Porto Alegre (HCPA). The authors thank to Universidade Federal do Rio Grande do Sul (UFRGS) and HCPA.

Keywords

Developmental toxicity
Animal model
Drug development
Congenital anomalies
Cartilage staining
Morphology

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Cite this

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abstract = " Pre-clinical trials are an essential step that underpins the drug discovery, development and safety process. During this process, animal testing is performed to determine the safety of new compounds and any potential adverse effects. Developmental toxicity tests are carried out to verify whether the drug has potential to cause congenital anomalies to the developing embryo/foetus. Chicken embryos are very useful for these purposes and present several advantages, such as low cost of production and housing, easy handling and manipulation, rapid development in addition to sharing similarities to the human embryo at molecular, cellular, and anatomical levels. In this chapter, we bring methods for using the chicken embryo model for testing the teratogenic effects of drugs and assessing the main outcomes of them.",

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N2 - Pre-clinical trials are an essential step that underpins the drug discovery, development and safety process. During this process, animal testing is performed to determine the safety of new compounds and any potential adverse effects. Developmental toxicity tests are carried out to verify whether the drug has potential to cause congenital anomalies to the developing embryo/foetus. Chicken embryos are very useful for these purposes and present several advantages, such as low cost of production and housing, easy handling and manipulation, rapid development in addition to sharing similarities to the human embryo at molecular, cellular, and anatomical levels. In this chapter, we bring methods for using the chicken embryo model for testing the teratogenic effects of drugs and assessing the main outcomes of them.

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Assessment of the Teratogenic Effect of Drugs on the Chicken Embryo

Abstract

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Bibliographical note

Keywords

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