Assessment of the Teratogenic Effect of Drugs on the Chicken Embryo

Lucas Rosa Fraga, Maikel Rosa de Oliveira, Karina Maria Wermann, Neil Vargesson

Research output: Chapter in Book/Report/Conference proceedingChapter


Pre-clinical trials are an essential step that underpins the drug discovery, development and safety process. During this process, animal testing is performed to determine the safety of new compounds and any potential adverse effects. Developmental toxicity tests are carried out to verify whether the drug has potential to cause congenital anomalies to the developing embryo/foetus. Chicken embryos are very useful for these purposes and present several advantages, such as low cost of production and housing, easy handling and manipulation, rapid development in addition to sharing similarities to the human embryo at molecular, cellular, and anatomical levels. In this chapter, we bring methods for using the chicken embryo model for testing the teratogenic effects of drugs and assessing the main outcomes of them.
Original languageEnglish
Title of host publicationMethods in Molecular Biology – Teratogenicity Testing Methods and Protocols
Publication statusAccepted/In press - 8 May 2023


  • Developmental toxicity
  • Animal model
  • Drug development
  • Congenital anomalies
  • Cartilage staining
  • Morphology


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