Assisted reproductive technology in Europe, 2004

results generated from European registers by ESHRE

A Nyboe Andersen, V Goossens, A P Ferraretti, Siladitya Bhattacharya, R Felberbaum, J de Mouzon, K G Nygren, European IVF-monitoring (EIM) Consortium

Research output: Contribution to journalArticle

273 Citations (Scopus)

Abstract

BACKGROUND: European results of assisted reproductive techniques from treatments initiated during 2004 are presented in this eighth report. METHODS: Data were mainly collected from existing national registers. From 29 countries, 785 clinics reported 367,066 treatment cycles including: IVF (114,672), ICSI (167,192), frozen embryo replacement (FER, 71,997), egg donation (ED, 10 334), preimplantation genetic diagnosis/screening (PGD/PGS, 2701) and in vitro maturation (IVM, 170). Overall, this represents only a marginal increase since 2003, due to a huge reduction in treatments in Germany. European data on intrauterine insemination using husband/partner's semen (IUI-H) and donor semen (IUI-D) were reported from 20 countries. A total of 115,980 cycles (IUI-H, 98,388; IUI-D, 17,592) were included. RESULTS: In 14 countries where all clinics reported to the IVF register, a total of 248,937 ART cycles were performed in a population of 261.6 million, corresponding to 1095 cycles per million inhabitants. For IVF, the clinical pregnancy rates per aspiration and per transfer were 26.6% and 30.1%, respectively. For ICSI, the corresponding rates were 27.1% and 29.8%. After IUI-H, the clinical pregnancy rate was 12.6% in women below 40. After IVF and ICSI, the distribution of transfer of 1, 2, 3 and 4 or more embryos was 19.2%, 55.3%, 22.1% and 3.3%, respectively. Compared with 2003, fewer embryos were transferred, but huge differences still existed between countries. The distribution of singleton, twin and triplet deliveries after IVF and ICSI combined was 77.2%, 21.7% and 1.0%, respectively. This gives a total multiple delivery rate of 22.7% compared with 23.1% in 2003 and 24.5% in 2002. After IUI-H in women below 40 years of age, 11.9% were twin and 1.3% triplet gestations. CONCLUSIONS: Compared with earlier years, the reported number of ART cycles in Europe increased and the pregnancy rates increased marginally, even though fewer embryos were transferred and the multiple delivery rates were reduced.
Original languageEnglish
Pages (from-to)756-771
Number of pages16
JournalHuman Reproduction
Volume23
Issue number4
Early online date14 Feb 2008
DOIs
Publication statusPublished - Apr 2008

Fingerprint

Assisted Reproductive Techniques
Intracytoplasmic Sperm Injections
Insemination
Semen
Spouses
Pregnancy Rate
Embryonic Structures
Tissue Donors
Preimplantation Diagnosis
Prostaglandins D
Genetic Testing
Ovum
Germany
Therapeutics
Pregnancy
Population

Keywords

  • Europe
  • Female
  • Fertilization in Vitro
  • Humans
  • Insemination, Artificial
  • Oocyte Donation
  • Pregnancy
  • Pregnancy Outcome
  • Pregnancy Rate
  • Preimplantation Diagnosis
  • Registries
  • Reproductive Techniques, Assisted

Cite this

Andersen, A. N., Goossens, V., Ferraretti, A. P., Bhattacharya, S., Felberbaum, R., de Mouzon, J., ... European IVF-monitoring (EIM) Consortium (2008). Assisted reproductive technology in Europe, 2004: results generated from European registers by ESHRE. Human Reproduction, 23(4), 756-771. https://doi.org/10.1093/humrep/den014

Assisted reproductive technology in Europe, 2004 : results generated from European registers by ESHRE. / Andersen, A Nyboe; Goossens, V; Ferraretti, A P; Bhattacharya, Siladitya; Felberbaum, R; de Mouzon, J; Nygren, K G; European IVF-monitoring (EIM) Consortium.

In: Human Reproduction, Vol. 23, No. 4, 04.2008, p. 756-771.

Research output: Contribution to journalArticle

Andersen, AN, Goossens, V, Ferraretti, AP, Bhattacharya, S, Felberbaum, R, de Mouzon, J, Nygren, KG & European IVF-monitoring (EIM) Consortium 2008, 'Assisted reproductive technology in Europe, 2004: results generated from European registers by ESHRE', Human Reproduction, vol. 23, no. 4, pp. 756-771. https://doi.org/10.1093/humrep/den014
Andersen, A Nyboe ; Goossens, V ; Ferraretti, A P ; Bhattacharya, Siladitya ; Felberbaum, R ; de Mouzon, J ; Nygren, K G ; European IVF-monitoring (EIM) Consortium. / Assisted reproductive technology in Europe, 2004 : results generated from European registers by ESHRE. In: Human Reproduction. 2008 ; Vol. 23, No. 4. pp. 756-771.
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abstract = "BACKGROUND: European results of assisted reproductive techniques from treatments initiated during 2004 are presented in this eighth report. METHODS: Data were mainly collected from existing national registers. From 29 countries, 785 clinics reported 367,066 treatment cycles including: IVF (114,672), ICSI (167,192), frozen embryo replacement (FER, 71,997), egg donation (ED, 10 334), preimplantation genetic diagnosis/screening (PGD/PGS, 2701) and in vitro maturation (IVM, 170). Overall, this represents only a marginal increase since 2003, due to a huge reduction in treatments in Germany. European data on intrauterine insemination using husband/partner's semen (IUI-H) and donor semen (IUI-D) were reported from 20 countries. A total of 115,980 cycles (IUI-H, 98,388; IUI-D, 17,592) were included. RESULTS: In 14 countries where all clinics reported to the IVF register, a total of 248,937 ART cycles were performed in a population of 261.6 million, corresponding to 1095 cycles per million inhabitants. For IVF, the clinical pregnancy rates per aspiration and per transfer were 26.6{\%} and 30.1{\%}, respectively. For ICSI, the corresponding rates were 27.1{\%} and 29.8{\%}. After IUI-H, the clinical pregnancy rate was 12.6{\%} in women below 40. After IVF and ICSI, the distribution of transfer of 1, 2, 3 and 4 or more embryos was 19.2{\%}, 55.3{\%}, 22.1{\%} and 3.3{\%}, respectively. Compared with 2003, fewer embryos were transferred, but huge differences still existed between countries. The distribution of singleton, twin and triplet deliveries after IVF and ICSI combined was 77.2{\%}, 21.7{\%} and 1.0{\%}, respectively. This gives a total multiple delivery rate of 22.7{\%} compared with 23.1{\%} in 2003 and 24.5{\%} in 2002. After IUI-H in women below 40 years of age, 11.9{\%} were twin and 1.3{\%} triplet gestations. CONCLUSIONS: Compared with earlier years, the reported number of ART cycles in Europe increased and the pregnancy rates increased marginally, even though fewer embryos were transferred and the multiple delivery rates were reduced.",
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T1 - Assisted reproductive technology in Europe, 2004

T2 - results generated from European registers by ESHRE

AU - Andersen, A Nyboe

AU - Goossens, V

AU - Ferraretti, A P

AU - Bhattacharya, Siladitya

AU - Felberbaum, R

AU - de Mouzon, J

AU - Nygren, K G

AU - European IVF-monitoring (EIM) Consortium

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N2 - BACKGROUND: European results of assisted reproductive techniques from treatments initiated during 2004 are presented in this eighth report. METHODS: Data were mainly collected from existing national registers. From 29 countries, 785 clinics reported 367,066 treatment cycles including: IVF (114,672), ICSI (167,192), frozen embryo replacement (FER, 71,997), egg donation (ED, 10 334), preimplantation genetic diagnosis/screening (PGD/PGS, 2701) and in vitro maturation (IVM, 170). Overall, this represents only a marginal increase since 2003, due to a huge reduction in treatments in Germany. European data on intrauterine insemination using husband/partner's semen (IUI-H) and donor semen (IUI-D) were reported from 20 countries. A total of 115,980 cycles (IUI-H, 98,388; IUI-D, 17,592) were included. RESULTS: In 14 countries where all clinics reported to the IVF register, a total of 248,937 ART cycles were performed in a population of 261.6 million, corresponding to 1095 cycles per million inhabitants. For IVF, the clinical pregnancy rates per aspiration and per transfer were 26.6% and 30.1%, respectively. For ICSI, the corresponding rates were 27.1% and 29.8%. After IUI-H, the clinical pregnancy rate was 12.6% in women below 40. After IVF and ICSI, the distribution of transfer of 1, 2, 3 and 4 or more embryos was 19.2%, 55.3%, 22.1% and 3.3%, respectively. Compared with 2003, fewer embryos were transferred, but huge differences still existed between countries. The distribution of singleton, twin and triplet deliveries after IVF and ICSI combined was 77.2%, 21.7% and 1.0%, respectively. This gives a total multiple delivery rate of 22.7% compared with 23.1% in 2003 and 24.5% in 2002. After IUI-H in women below 40 years of age, 11.9% were twin and 1.3% triplet gestations. CONCLUSIONS: Compared with earlier years, the reported number of ART cycles in Europe increased and the pregnancy rates increased marginally, even though fewer embryos were transferred and the multiple delivery rates were reduced.

AB - BACKGROUND: European results of assisted reproductive techniques from treatments initiated during 2004 are presented in this eighth report. METHODS: Data were mainly collected from existing national registers. From 29 countries, 785 clinics reported 367,066 treatment cycles including: IVF (114,672), ICSI (167,192), frozen embryo replacement (FER, 71,997), egg donation (ED, 10 334), preimplantation genetic diagnosis/screening (PGD/PGS, 2701) and in vitro maturation (IVM, 170). Overall, this represents only a marginal increase since 2003, due to a huge reduction in treatments in Germany. European data on intrauterine insemination using husband/partner's semen (IUI-H) and donor semen (IUI-D) were reported from 20 countries. A total of 115,980 cycles (IUI-H, 98,388; IUI-D, 17,592) were included. RESULTS: In 14 countries where all clinics reported to the IVF register, a total of 248,937 ART cycles were performed in a population of 261.6 million, corresponding to 1095 cycles per million inhabitants. For IVF, the clinical pregnancy rates per aspiration and per transfer were 26.6% and 30.1%, respectively. For ICSI, the corresponding rates were 27.1% and 29.8%. After IUI-H, the clinical pregnancy rate was 12.6% in women below 40. After IVF and ICSI, the distribution of transfer of 1, 2, 3 and 4 or more embryos was 19.2%, 55.3%, 22.1% and 3.3%, respectively. Compared with 2003, fewer embryos were transferred, but huge differences still existed between countries. The distribution of singleton, twin and triplet deliveries after IVF and ICSI combined was 77.2%, 21.7% and 1.0%, respectively. This gives a total multiple delivery rate of 22.7% compared with 23.1% in 2003 and 24.5% in 2002. After IUI-H in women below 40 years of age, 11.9% were twin and 1.3% triplet gestations. CONCLUSIONS: Compared with earlier years, the reported number of ART cycles in Europe increased and the pregnancy rates increased marginally, even though fewer embryos were transferred and the multiple delivery rates were reduced.

KW - Europe

KW - Female

KW - Fertilization in Vitro

KW - Humans

KW - Insemination, Artificial

KW - Oocyte Donation

KW - Pregnancy

KW - Pregnancy Outcome

KW - Pregnancy Rate

KW - Preimplantation Diagnosis

KW - Registries

KW - Reproductive Techniques, Assisted

U2 - 10.1093/humrep/den014

DO - 10.1093/humrep/den014

M3 - Article

VL - 23

SP - 756

EP - 771

JO - Human Reproduction

JF - Human Reproduction

SN - 0268-1161

IS - 4

ER -