Association between angiotensin-converting enzyme gene and late onset Alzheimer's disease in Han Chinese

J D Yang, G Y Feng, J Zhang, Z X Lin, T Shen, G Breen, D St Clair, L He

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There is now overwhelming evidence that the epsilon4 allele of apolipoprotein (APOE) gene is a major risk factor for late-onset Alzheimer's disease (AD). However, the APOE locus only accounts for a proportion of the overall genetic risk for AD. The angiotensin-converting enzyme (ACE) is widely expressed in the brain and may have a role in AD. Recently an insertion/deletion (IID) DNA polymorphism at the intron 16 of ACE gene has been found associated with late-onset AD, but the results are not consistent. We have examined ACE gene in a cohort of Han Chinese AD cases and controls. We have found the ACE-I allele was enriched in our cases compared to controls (odds ratio (OR) = 2.09, P = 0.0043). The phenomenon was restricted to cases presenting with AD after the age of 70 years (P < 0.0005), and was independent of APOE genotype. We conclude that ACE genotype is a risk factor for late onset AD. (C) 2000 Published by Elsevier Science ireland Ltd.

Original languageEnglish
Pages (from-to)41-44
Number of pages4
JournalNeuroscience Letters
Publication statusPublished - 2000


  • angiotensin-converting enzyme
  • Alzheimer's disease
  • apolipoprotein
  • DCP1

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