There is now overwhelming evidence that the epsilon4 allele of apolipoprotein (APOE) gene is a major risk factor for late-onset Alzheimer's disease (AD). However, the APOE locus only accounts for a proportion of the overall genetic risk for AD. The angiotensin-converting enzyme (ACE) is widely expressed in the brain and may have a role in AD. Recently an insertion/deletion (IID) DNA polymorphism at the intron 16 of ACE gene has been found associated with late-onset AD, but the results are not consistent. We have examined ACE gene in a cohort of Han Chinese AD cases and controls. We have found the ACE-I allele was enriched in our cases compared to controls (odds ratio (OR) = 2.09, P = 0.0043). The phenomenon was restricted to cases presenting with AD after the age of 70 years (P < 0.0005), and was independent of APOE genotype. We conclude that ACE genotype is a risk factor for late onset AD. (C) 2000 Published by Elsevier Science ireland Ltd.
|Number of pages||4|
|Publication status||Published - 2000|
- angiotensin-converting enzyme
- Alzheimer's disease
- DELETION ALLELE
- ACE LEVELS