Association between angiotensin-converting enzyme gene and late onset Alzheimer's disease in Han Chinese

J D Yang, G Y Feng, J Zhang, Z X Lin, T Shen, G Breen, D St Clair, L He

Research output: Contribution to journalArticle

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Abstract

There is now overwhelming evidence that the epsilon4 allele of apolipoprotein (APOE) gene is a major risk factor for late-onset Alzheimer's disease (AD). However, the APOE locus only accounts for a proportion of the overall genetic risk for AD. The angiotensin-converting enzyme (ACE) is widely expressed in the brain and may have a role in AD. Recently an insertion/deletion (IID) DNA polymorphism at the intron 16 of ACE gene has been found associated with late-onset AD, but the results are not consistent. We have examined ACE gene in a cohort of Han Chinese AD cases and controls. We have found the ACE-I allele was enriched in our cases compared to controls (odds ratio (OR) = 2.09, P = 0.0043). The phenomenon was restricted to cases presenting with AD after the age of 70 years (P < 0.0005), and was independent of APOE genotype. We conclude that ACE genotype is a risk factor for late onset AD. (C) 2000 Published by Elsevier Science ireland Ltd.

Original languageEnglish
Pages (from-to)41-44
Number of pages4
JournalNeuroscience Letters
Volume295
Publication statusPublished - 2000

Keywords

  • angiotensin-converting enzyme
  • Alzheimer's disease
  • apolipoprotein
  • DELETION ALLELE
  • ACE LEVELS
  • SUSCEPTIBILITY
  • DEMENTIA
  • DCP1

Cite this

Yang, J. D., Feng, G. Y., Zhang, J., Lin, Z. X., Shen, T., Breen, G., ... He, L. (2000). Association between angiotensin-converting enzyme gene and late onset Alzheimer's disease in Han Chinese. Neuroscience Letters, 295, 41-44.

Association between angiotensin-converting enzyme gene and late onset Alzheimer's disease in Han Chinese. / Yang, J D ; Feng, G Y ; Zhang, J ; Lin, Z X ; Shen, T ; Breen, G ; St Clair, D ; He, L .

In: Neuroscience Letters, Vol. 295, 2000, p. 41-44.

Research output: Contribution to journalArticle

Yang, JD, Feng, GY, Zhang, J, Lin, ZX, Shen, T, Breen, G, St Clair, D & He, L 2000, 'Association between angiotensin-converting enzyme gene and late onset Alzheimer's disease in Han Chinese', Neuroscience Letters, vol. 295, pp. 41-44.
Yang, J D ; Feng, G Y ; Zhang, J ; Lin, Z X ; Shen, T ; Breen, G ; St Clair, D ; He, L . / Association between angiotensin-converting enzyme gene and late onset Alzheimer's disease in Han Chinese. In: Neuroscience Letters. 2000 ; Vol. 295. pp. 41-44.
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AU - Feng, G Y

AU - Zhang, J

AU - Lin, Z X

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AU - Breen, G

AU - St Clair, D

AU - He, L

PY - 2000

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AB - There is now overwhelming evidence that the epsilon4 allele of apolipoprotein (APOE) gene is a major risk factor for late-onset Alzheimer's disease (AD). However, the APOE locus only accounts for a proportion of the overall genetic risk for AD. The angiotensin-converting enzyme (ACE) is widely expressed in the brain and may have a role in AD. Recently an insertion/deletion (IID) DNA polymorphism at the intron 16 of ACE gene has been found associated with late-onset AD, but the results are not consistent. We have examined ACE gene in a cohort of Han Chinese AD cases and controls. We have found the ACE-I allele was enriched in our cases compared to controls (odds ratio (OR) = 2.09, P = 0.0043). The phenomenon was restricted to cases presenting with AD after the age of 70 years (P < 0.0005), and was independent of APOE genotype. We conclude that ACE genotype is a risk factor for late onset AD. (C) 2000 Published by Elsevier Science ireland Ltd.

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KW - Alzheimer's disease

KW - apolipoprotein

KW - DELETION ALLELE

KW - ACE LEVELS

KW - SUSCEPTIBILITY

KW - DEMENTIA

KW - DCP1

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