Association between telomere length and heart disease in a narrow age cohort of older people

John M. Starr, Brian McGurn, Sarah E. Harris, Lawrence Jeffrey Whalley, Ian J. Deary, Paul G. Shiels

    Research output: Contribution to journalArticle

    37 Citations (Scopus)

    Abstract

    Telomere shortening is a feature of cellular ageing common to a range of human tissues. Shorter telomeres are associated with an increased likelihood of mortality, including death from heart disease. We examined the association between telomere length and heart disease (present in 33%) in a well-characterised, narrow age cohort of older people (n = 190, all born in 1921), and tested for any concomitant effects of medication use. Mean telomere length was significantly shorter in participants who reported heart disease (p = .001). Participants with ischemic changes on ECG had shorter telomere lengths (6.67 versus 7.65 kb, p = .021) after adjusting for other ECG abnormalities. This finding adds to the growing body of evidence for an association between telomere shortening and ischemic heart disease. Telomere shortening in peripheral blood leukocytes is a promising index of ischemic heart disease risk in older people and deserves further investigation as a potential mechanism.
    Original languageEnglish
    Pages (from-to)571-573
    Number of pages3
    JournalExperimental Gerontology
    Volume42
    Issue number6
    Early online date20 Dec 2006
    DOIs
    Publication statusPublished - Jun 2007

    Fingerprint

    Telomere
    Telomere Shortening
    Heart Diseases
    Myocardial Ischemia
    Electrocardiography
    Cell Aging
    Leukocytes
    Blood
    Aging of materials
    Mortality
    Tissue

    Keywords

    • telomeres
    • ageing
    • ischemic heart disease
    • electrocardiogram
    • humans

    Cite this

    Starr, J. M., McGurn, B., Harris, S. E., Whalley, L. J., Deary, I. J., & Shiels, P. G. (2007). Association between telomere length and heart disease in a narrow age cohort of older people. Experimental Gerontology, 42(6), 571-573. https://doi.org/10.1016/j.exger.2006.12.002

    Association between telomere length and heart disease in a narrow age cohort of older people. / Starr, John M.; McGurn, Brian; Harris, Sarah E.; Whalley, Lawrence Jeffrey; Deary, Ian J.; Shiels, Paul G.

    In: Experimental Gerontology, Vol. 42, No. 6, 06.2007, p. 571-573.

    Research output: Contribution to journalArticle

    Starr, JM, McGurn, B, Harris, SE, Whalley, LJ, Deary, IJ & Shiels, PG 2007, 'Association between telomere length and heart disease in a narrow age cohort of older people' Experimental Gerontology, vol. 42, no. 6, pp. 571-573. https://doi.org/10.1016/j.exger.2006.12.002
    Starr, John M. ; McGurn, Brian ; Harris, Sarah E. ; Whalley, Lawrence Jeffrey ; Deary, Ian J. ; Shiels, Paul G. / Association between telomere length and heart disease in a narrow age cohort of older people. In: Experimental Gerontology. 2007 ; Vol. 42, No. 6. pp. 571-573.
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