Association between vitamin D receptor gene polymorphisms, falls, balance and muscle power: results from two independent studies (APOSS and OPUS)

R. Barr, H. MacDonald, A. Stewart, F. McGuigan, A. Rogers, R. Eastell, D. Felsenberg, C. Gluer, C. Roux, D. M. Reid

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

Fall prevention is a key strategy for reducing osteoporotic fractures. We investigated the association between vitamin D receptor (VDR) polymorphisms and reported falls in postmenopausal women. Bsm1 polymorphisms were associated with falls, balance and muscle power measurements. These results may explain some of the excess fracture risk associated with VDR in some studies.

Fall prevention is a key strategy for reducing osteoporotic fractures. It has been suggested that vitamin D supplementation may reduce the incidence of falls by reducing body sway and increasing muscle power. The vitamin D receptor gene is a well-studied candidate gene for osteoporosis. We investigated the association between VDR polymorphisms and reported falls in postmenopausal women.

Falls data were collected in two separate population cohorts. Five polymorphisms of the VDR gene were analysed (Cdx-2, Fok-1, BsmI, Taq1 and Apa1) in the Aberdeen Prospective Osteoporosis Screening Study (APOSS) cohort. Results found in APOSS were then validated in an independent cohort-the Osteoporosis and Ultrasound (OPUS) study (Bsm1 and Fok1 only), where muscle power and balance were also measured.

Carriers of the 'B' allele (Bsm1) showed an increased risk for falls. In APOSS, this was statistically significant for visit 3 multiple falls (p = 0.047) and for recurrent falls (p = 0.043). Similar results were found in OPUS for visit 1 falls (p = 0.025) and visit 1 multiple falls (p = 0.015). Bsm1 polymorphisms were also associated with balance and muscle power measurements.

In conclusion, these results demonstrate an association between the Bsm1 polymorphism and risk of falling that may explain some of the excess fracture risk associated with VDR in some studies.

Original languageEnglish
Pages (from-to)457-466
Number of pages10
JournalOsteoporosis International
Volume21
Issue number3
Early online date24 Jul 2009
DOIs
Publication statusPublished - 1 Mar 2010

Keywords

  • balance
  • falls
  • muscle power
  • vitamin D receptor gene
  • bone-mineral density
  • postmenopausal women
  • elderly-women
  • fracture risk
  • hip fracture
  • population
  • strength
  • osteoporosis
  • metaanalysis
  • people
  • vitamin D recptor gene

Cite this

Association between vitamin D receptor gene polymorphisms, falls, balance and muscle power : results from two independent studies (APOSS and OPUS). / Barr, R.; MacDonald, H.; Stewart, A.; McGuigan, F.; Rogers, A.; Eastell, R.; Felsenberg, D.; Gluer, C.; Roux, C.; Reid, D. M.

In: Osteoporosis International, Vol. 21, No. 3, 01.03.2010, p. 457-466.

Research output: Contribution to journalArticle

Barr, R. ; MacDonald, H. ; Stewart, A. ; McGuigan, F. ; Rogers, A. ; Eastell, R. ; Felsenberg, D. ; Gluer, C. ; Roux, C. ; Reid, D. M. / Association between vitamin D receptor gene polymorphisms, falls, balance and muscle power : results from two independent studies (APOSS and OPUS). In: Osteoporosis International. 2010 ; Vol. 21, No. 3. pp. 457-466.
@article{4d18c3aefa26436a9b22df332cdf8e90,
title = "Association between vitamin D receptor gene polymorphisms, falls, balance and muscle power: results from two independent studies (APOSS and OPUS)",
abstract = "Fall prevention is a key strategy for reducing osteoporotic fractures. We investigated the association between vitamin D receptor (VDR) polymorphisms and reported falls in postmenopausal women. Bsm1 polymorphisms were associated with falls, balance and muscle power measurements. These results may explain some of the excess fracture risk associated with VDR in some studies.Fall prevention is a key strategy for reducing osteoporotic fractures. It has been suggested that vitamin D supplementation may reduce the incidence of falls by reducing body sway and increasing muscle power. The vitamin D receptor gene is a well-studied candidate gene for osteoporosis. We investigated the association between VDR polymorphisms and reported falls in postmenopausal women.Falls data were collected in two separate population cohorts. Five polymorphisms of the VDR gene were analysed (Cdx-2, Fok-1, BsmI, Taq1 and Apa1) in the Aberdeen Prospective Osteoporosis Screening Study (APOSS) cohort. Results found in APOSS were then validated in an independent cohort-the Osteoporosis and Ultrasound (OPUS) study (Bsm1 and Fok1 only), where muscle power and balance were also measured.Carriers of the 'B' allele (Bsm1) showed an increased risk for falls. In APOSS, this was statistically significant for visit 3 multiple falls (p = 0.047) and for recurrent falls (p = 0.043). Similar results were found in OPUS for visit 1 falls (p = 0.025) and visit 1 multiple falls (p = 0.015). Bsm1 polymorphisms were also associated with balance and muscle power measurements.In conclusion, these results demonstrate an association between the Bsm1 polymorphism and risk of falling that may explain some of the excess fracture risk associated with VDR in some studies.",
keywords = "balance, falls, muscle power, vitamin D receptor gene, bone-mineral density, postmenopausal women, elderly-women, fracture risk, hip fracture, population, strength, osteoporosis, metaanalysis, people, vitamin D recptor gene",
author = "R. Barr and H. MacDonald and A. Stewart and F. McGuigan and A. Rogers and R. Eastell and D. Felsenberg and C. Gluer and C. Roux and Reid, {D. M.}",
year = "2010",
month = "3",
day = "1",
doi = "10.1007/s00198-009-1019-6",
language = "English",
volume = "21",
pages = "457--466",
journal = "Osteoporosis International",
issn = "0937-941X",
publisher = "SPRINGER-VERLAG LONDON LTD",
number = "3",

}

TY - JOUR

T1 - Association between vitamin D receptor gene polymorphisms, falls, balance and muscle power

T2 - results from two independent studies (APOSS and OPUS)

AU - Barr, R.

AU - MacDonald, H.

AU - Stewart, A.

AU - McGuigan, F.

AU - Rogers, A.

AU - Eastell, R.

AU - Felsenberg, D.

AU - Gluer, C.

AU - Roux, C.

AU - Reid, D. M.

PY - 2010/3/1

Y1 - 2010/3/1

N2 - Fall prevention is a key strategy for reducing osteoporotic fractures. We investigated the association between vitamin D receptor (VDR) polymorphisms and reported falls in postmenopausal women. Bsm1 polymorphisms were associated with falls, balance and muscle power measurements. These results may explain some of the excess fracture risk associated with VDR in some studies.Fall prevention is a key strategy for reducing osteoporotic fractures. It has been suggested that vitamin D supplementation may reduce the incidence of falls by reducing body sway and increasing muscle power. The vitamin D receptor gene is a well-studied candidate gene for osteoporosis. We investigated the association between VDR polymorphisms and reported falls in postmenopausal women.Falls data were collected in two separate population cohorts. Five polymorphisms of the VDR gene were analysed (Cdx-2, Fok-1, BsmI, Taq1 and Apa1) in the Aberdeen Prospective Osteoporosis Screening Study (APOSS) cohort. Results found in APOSS were then validated in an independent cohort-the Osteoporosis and Ultrasound (OPUS) study (Bsm1 and Fok1 only), where muscle power and balance were also measured.Carriers of the 'B' allele (Bsm1) showed an increased risk for falls. In APOSS, this was statistically significant for visit 3 multiple falls (p = 0.047) and for recurrent falls (p = 0.043). Similar results were found in OPUS for visit 1 falls (p = 0.025) and visit 1 multiple falls (p = 0.015). Bsm1 polymorphisms were also associated with balance and muscle power measurements.In conclusion, these results demonstrate an association between the Bsm1 polymorphism and risk of falling that may explain some of the excess fracture risk associated with VDR in some studies.

AB - Fall prevention is a key strategy for reducing osteoporotic fractures. We investigated the association between vitamin D receptor (VDR) polymorphisms and reported falls in postmenopausal women. Bsm1 polymorphisms were associated with falls, balance and muscle power measurements. These results may explain some of the excess fracture risk associated with VDR in some studies.Fall prevention is a key strategy for reducing osteoporotic fractures. It has been suggested that vitamin D supplementation may reduce the incidence of falls by reducing body sway and increasing muscle power. The vitamin D receptor gene is a well-studied candidate gene for osteoporosis. We investigated the association between VDR polymorphisms and reported falls in postmenopausal women.Falls data were collected in two separate population cohorts. Five polymorphisms of the VDR gene were analysed (Cdx-2, Fok-1, BsmI, Taq1 and Apa1) in the Aberdeen Prospective Osteoporosis Screening Study (APOSS) cohort. Results found in APOSS were then validated in an independent cohort-the Osteoporosis and Ultrasound (OPUS) study (Bsm1 and Fok1 only), where muscle power and balance were also measured.Carriers of the 'B' allele (Bsm1) showed an increased risk for falls. In APOSS, this was statistically significant for visit 3 multiple falls (p = 0.047) and for recurrent falls (p = 0.043). Similar results were found in OPUS for visit 1 falls (p = 0.025) and visit 1 multiple falls (p = 0.015). Bsm1 polymorphisms were also associated with balance and muscle power measurements.In conclusion, these results demonstrate an association between the Bsm1 polymorphism and risk of falling that may explain some of the excess fracture risk associated with VDR in some studies.

KW - balance

KW - falls

KW - muscle power

KW - vitamin D receptor gene

KW - bone-mineral density

KW - postmenopausal women

KW - elderly-women

KW - fracture risk

KW - hip fracture

KW - population

KW - strength

KW - osteoporosis

KW - metaanalysis

KW - people

KW - vitamin D recptor gene

U2 - 10.1007/s00198-009-1019-6

DO - 10.1007/s00198-009-1019-6

M3 - Article

VL - 21

SP - 457

EP - 466

JO - Osteoporosis International

JF - Osteoporosis International

SN - 0937-941X

IS - 3

ER -