Association of glutamine 27 polymorphism of beta2 adrenoceptor childhood with reported asthma is age-dependent

E Hopes, C McDougall, G Christie, J Dewar, A Wheatley, I P Hall, Peter Joseph Benedict Helms

Research output: Contribution to journal › Article

Abstract

The prevalence of asthma in children has doubled over the past 25 years.1 Two common polymorphisms exist in the β adrenoceptor at amino acids 16 (glycine for arginine) and 27 (glutamic acid for glutamine). Both are functionally relevant in cultured cells, with the glycine 16 form of the receptor showing enhanced downregulation and the glutamic acid 27 form showing attenuated downregulation after exposure to β agonists.2 The glutamine 27 polymorphism is associated with raised IgE concentrations in families with a history of asthma, and with increased reactivity of the airways in people with asthma.3,4 We measured the prevalence of these polymorphisms in a random population of children to identify their importance in the expression of reported asthma.
Original languageEnglish
Number of pages1
JournalThorax
Volume55
Publication statusPublished - Dec 2000

Keywords

  • BETA(2)-ADRENOCEPTOR

Cite this

Hopes, E., McDougall, C., Christie, G., Dewar, J., Wheatley, A., Hall, I. P., & Helms, P. J. B. (2000). Association of glutamine 27 polymorphism of beta2 adrenoceptor childhood with reported asthma is age-dependent. Thorax, 55.

Association of glutamine 27 polymorphism of beta2 adrenoceptor childhood with reported asthma is age-dependent. / Hopes, E ; McDougall, C ; Christie, G; Dewar, J ; Wheatley, A ; Hall, I P ; Helms, Peter Joseph Benedict.

In: Thorax, Vol. 55, 12.2000.

Research output: Contribution to journal › Article

Hopes, E, McDougall, C, Christie, G, Dewar, J, Wheatley, A, Hall, IP & Helms, PJB 2000, 'Association of glutamine 27 polymorphism of beta2 adrenoceptor childhood with reported asthma is age-dependent', Thorax, vol. 55.
Hopes E, McDougall C, Christie G, Dewar J, Wheatley A, Hall IP et al. Association of glutamine 27 polymorphism of beta2 adrenoceptor childhood with reported asthma is age-dependent. Thorax. 2000 Dec;55.
Hopes, E ; McDougall, C ; Christie, G ; Dewar, J ; Wheatley, A ; Hall, I P ; Helms, Peter Joseph Benedict. / Association of glutamine 27 polymorphism of beta2 adrenoceptor childhood with reported asthma is age-dependent. In: Thorax. 2000 ; Vol. 55.
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T1 - Association of glutamine 27 polymorphism of beta2 adrenoceptor childhood with reported asthma is age-dependent

AU - Hopes, E

AU - McDougall, C

AU - Christie, G

AU - Dewar, J

AU - Wheatley, A

AU - Hall, I P

AU - Helms, Peter Joseph Benedict

PY - 2000/12

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N2 - The prevalence of asthma in children has doubled over the past 25 years.1 Two common polymorphisms exist in the β adrenoceptor at amino acids 16 (glycine for arginine) and 27 (glutamic acid for glutamine). Both are functionally relevant in cultured cells, with the glycine 16 form of the receptor showing enhanced downregulation and the glutamic acid 27 form showing attenuated downregulation after exposure to β agonists.2 The glutamine 27 polymorphism is associated with raised IgE concentrations in families with a history of asthma, and with increased reactivity of the airways in people with asthma.3,4 We measured the prevalence of these polymorphisms in a random population of children to identify their importance in the expression of reported asthma.

AB - The prevalence of asthma in children has doubled over the past 25 years.1 Two common polymorphisms exist in the β adrenoceptor at amino acids 16 (glycine for arginine) and 27 (glutamic acid for glutamine). Both are functionally relevant in cultured cells, with the glycine 16 form of the receptor showing enhanced downregulation and the glutamic acid 27 form showing attenuated downregulation after exposure to β agonists.2 The glutamine 27 polymorphism is associated with raised IgE concentrations in families with a history of asthma, and with increased reactivity of the airways in people with asthma.3,4 We measured the prevalence of these polymorphisms in a random population of children to identify their importance in the expression of reported asthma.

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