Abstract
Background: Obesity is a major risk factor of chronic-diseases, including cardiovascular-diseases (CVD). Increasing evidence is showing the association of heat-shock protein (HSP) with type-2 diabetes and CVD; however, there is little data on the relationship between the genetic-polymorphisms of HSP70-2 with obesity. Aim: The present study has investigated the association between 1267HSP70-2 genetic polymorphism and obesity in an Iranian population with 317 subjects. Subjects and methods: Anthropometric parameters and biochemical measurements were measured in all the samples, while genotypes were determined using PCR-RFLP. Univariate/multivariate analyses were conducted to explore the relationship between the genetic-polymorphisms and obesity. Results: The data showed a significant association between 1267HSP70-2 polymorphism in obese subjects, compared to the non-obese group. Moreover, it was observed that this polymorphism was associated with obesity in the CAD + group, which had a high BMI compared to non-obese controls. Conclusion: The 1267HSP70-2 polymorphism is associated with obesity in an Iranian population, supporting a possible potential genetic link between obesity and cardiovascular diseases.
| Original language | English |
|---|---|
| Pages (from-to) | 542-546 |
| Number of pages | 5 |
| Journal | Annals of Human Biology |
| Volume | 43 |
| Issue number | 6 |
| Early online date | 10 Feb 2016 |
| DOIs | |
| Publication status | Published - 1 Nov 2016 |
Keywords
- coronary artery disease
- heat shock protein 70
- Obesity
- PCR-RFLP
- polymorphism
Access to Document
- Mardan_nik_etal_Association_heat_shock_VOR
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