Association of heat shock protein70-2 (HSP70-2) gene polymorphism with obesity

Maryam Mardan-Nik, Alireza Pasdar, Khadijeh Jamialahmadi, Amir Avan, Mohsen Mohebati, Habibollah Esmaily, Atefeh Biabangard-Zak, Fahimeh Afzal Javan, Mahdi Rivandi, Gordon A. Ferns, Majid Ghayour-Mobarhan*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)

Abstract

Background: Obesity is a major risk factor of chronic-diseases, including cardiovascular-diseases (CVD). Increasing evidence is showing the association of heat-shock protein (HSP) with type-2 diabetes and CVD; however, there is little data on the relationship between the genetic-polymorphisms of HSP70-2 with obesity. Aim: The present study has investigated the association between 1267HSP70-2 genetic polymorphism and obesity in an Iranian population with 317 subjects. Subjects and methods: Anthropometric parameters and biochemical measurements were measured in all the samples, while genotypes were determined using PCR-RFLP. Univariate/multivariate analyses were conducted to explore the relationship between the genetic-polymorphisms and obesity. Results: The data showed a significant association between 1267HSP70-2 polymorphism in obese subjects, compared to the non-obese group. Moreover, it was observed that this polymorphism was associated with obesity in the CAD + group, which had a high BMI compared to non-obese controls. Conclusion: The 1267HSP70-2 polymorphism is associated with obesity in an Iranian population, supporting a possible potential genetic link between obesity and cardiovascular diseases.

Original languageEnglish
Pages (from-to)542-546
Number of pages5
JournalAnnals of Human Biology
Volume43
Issue number6
Early online date10 Feb 2016
DOIs
Publication statusPublished - 1 Nov 2016

Keywords

  • coronary artery disease
  • heat shock protein 70
  • Obesity
  • PCR-RFLP
  • polymorphism

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