Association of Helicobacter pylori infection with the risk of metabolic syndrome and insulin resistance: an updated systematic review and meta-analysis

Mobin Azami, Hamid Reza Baradaran, Hojat Dehghanbanadaki, Parisa Kohnepoushi, Lotfolah Saed, Asra Moradkhani, Farhad Moradpour, Yousef Moradi*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Conflicting results of recent studies on the association between Helicobacter pylori (H. pylori) infection and the risk of insulin resistance and metabolic syndrome explored the need for updated meta-analysis on this issue. Therefore, this systematic review aimed to estimate the pooled effect of H. pylori infection on the risk of insulin resistance and metabolic syndrome. Methods: To identify case–control studies and cohort studies evaluating the association of H. pylori infection with insulin resistance and metabolic syndrome, a comprehensive literature search was performed from international databases including Medline (PubMed), Web of Sciences, Scopus, EMBASE, and CINHAL from January 1990 until January 2021. We used odds ratio with its 95% confidence interval to quantify the effect of case–control studies and risk ratio with its 95% CI for the effect of cohort studies. Results: 22 studies with 206,911 participants were included for meta-analysis. The pooled estimate of odds ratio between H. pylori infection and metabolic syndrome in case–control studies was 1.19 (95% CI 1.05–1.35; I2 = 0%), and in cohort studies, the pooled risk ratio was 1.31 (95% CI 1.13–1.51; I2 = 0%). Besides, case–control studies showed the pooled odds ratio of 1.54 (95% CI 1.19–1.98; I2 = 6.88%) for the association between H. pylori infection and insulin resistance. Conclusion: In this meta-analysis, the results showed that there was a possibility of metabolic syndrome and insulin resistance in case of H. pylori infection.

Original languageEnglish
Article number145
Number of pages18
JournalDiabetology and Metabolic Syndrome
Volume13
Issue number1
Early online date18 Dec 2021
DOIs
Publication statusPublished - 18 Dec 2021

Keywords

  • Helicobacter pylori
  • Insulin resistance
  • Meta-analysis
  • Metabolic syndrome
  • Systematic review

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