Association of novel genetic Loci with circulating fibrinogen levels: a genome-wide association study in 6 population-based cohorts

Abbas Dehghan; Qiong Yang; Annette Peters; Saonli Basu; Joshua C Bis; Alicja R Rudnicka; Maryam Kavousi; Mei Chen; Jens Baumert; Gordon D O Lowe; Barbara McKnight; Weihong Tang; Moniek de Maat; Marian Larson; Susana Eyhermendy; Wendy L McArdle; Thomas Lumley; James S Pankow; Albert Hofman; Joseph M Massaro; Fernando Rivadeneira; Melanie Kolz; Kent D.  Taylor; Cornelia M van Duijn; Sekar Kathiresan; Thomas Illig; Yurii S Aulchenko; Kelly A Volcik; Andrew D. Johnson; Andre G Uitterlinden; Geoffrey H Tofler; Christian Gieger; Bruce M Psaty; David J Couper; Eric Boerwinkle; Wolfgang Koenig; Christopher J O'Donnell; Jacqueline C Witteman; David P.  Strachan; Nicholas L Smith; Aaron R Folsom; Wellcome Trust Case Control Consortium

doi:10.1161/CIRCGENETICS.108.825224

Association of novel genetic Loci with circulating fibrinogen levels: a genome-wide association study in 6 population-based cohorts

Abbas Dehghan, Qiong Yang, Annette Peters, Saonli Basu, Joshua C Bis, Alicja R Rudnicka, Maryam Kavousi, Mei Chen, Jens Baumert, Gordon D O Lowe, Barbara McKnight, Weihong Tang, Moniek de Maat, Marian Larson, Susana Eyhermendy, Wendy L McArdle, Thomas Lumley, James S Pankow, Albert Hofman, Joseph M MassaroFernando Rivadeneira, Melanie Kolz, Kent D. Taylor, Cornelia M van Duijn, Sekar Kathiresan, Thomas Illig, Yurii S Aulchenko, Kelly A Volcik, Andrew D. Johnson, Andre G Uitterlinden, Geoffrey H Tofler, Christian Gieger, Bruce M Psaty, David J Couper, Eric Boerwinkle, Wolfgang Koenig, Christopher J O'Donnell, Jacqueline C Witteman, David P. Strachan, Nicholas L Smith, Aaron R Folsom, Wellcome Trust Case Control Consortium

Medical Sciences

Research output: Contribution to journal › Article › peer-review

84 Citations (Scopus)

Abstract

BACKGROUND: Fibrinogen is both central to blood coagulation and an acute-phase reactant. We aimed to identify common variants influencing circulation fibrinogen levels. METHODS AND RESULTS: We conducted a genome-wide association analysis on 6 population-based studies, the Rotterdam Study, the Framingham Heart Study, the Cardiovascular Health Study, the Atherosclerosis Risk in Communities Study, the Monitoring of Trends and Determinants in Cardiovascular Disease/KORA Augsburg Study, and the British 1958 Birth Cohort Study, including 22 096 participants of European ancestry. Four loci were marked by 1 or more single-nucleotide polymorphisms that demonstrated genome-wide significance (P

Original language	English
Pages (from-to)	125-133
Number of pages	9
Journal	Circulation. Cardiovascular Genetics
Volume	2
Issue number	2
DOIs	https://doi.org/10.1161/CIRCGENETICS.108.825224
Publication status	Published - 1 Apr 2009

Keywords

Adult
Aged
Aged, 80 and over
Cardiovascular Diseases
Cohort Studies
European Continental Ancestry Group
Female
Fibrinogen
Genetic Loci
Genome-Wide Association Study
Humans
Male
Middle Aged
Pedigree
Polymorphism, Single Nucleotide
Young Adult
genome-wide association study
fibrinogen
genes
meta-analysis

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1161/CIRCGENETICS.108.825224

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Dehghan, A., Yang, Q., Peters, A., Basu, S., Bis, J. C., Rudnicka, A. R., Kavousi, M., Chen, M., Baumert, J., Lowe, G. D. O., McKnight, B., Tang, W., de Maat, M., Larson, M., Eyhermendy, S., McArdle, W. L., Lumley, T., Pankow, J. S., Hofman, A., ... Wellcome Trust Case Control Consortium (2009). Association of novel genetic Loci with circulating fibrinogen levels: a genome-wide association study in 6 population-based cohorts. Circulation. Cardiovascular Genetics, 2(2), 125-133. https://doi.org/10.1161/CIRCGENETICS.108.825224

Dehghan, A, Yang, Q, Peters, A, Basu, S, Bis, JC, Rudnicka, AR, Kavousi, M, Chen, M, Baumert, J, Lowe, GDO, McKnight, B, Tang, W, de Maat, M, Larson, M, Eyhermendy, S, McArdle, WL, Lumley, T, Pankow, JS, Hofman, A, Massaro, JM, Rivadeneira, F, Kolz, M, Taylor, KD, van Duijn, CM, Kathiresan, S, Illig, T, Aulchenko, YS, Volcik, KA, Johnson, AD, Uitterlinden, AG, Tofler, GH, Gieger, C, Psaty, BM, Couper, DJ, Boerwinkle, E, Koenig, W, O'Donnell, CJ, Witteman, JC, Strachan, DP, Smith, NL, Folsom, AR & Wellcome Trust Case Control Consortium 2009, 'Association of novel genetic Loci with circulating fibrinogen levels: a genome-wide association study in 6 population-based cohorts', Circulation. Cardiovascular Genetics, vol. 2, no. 2, pp. 125-133. https://doi.org/10.1161/CIRCGENETICS.108.825224

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abstract = "BACKGROUND: Fibrinogen is both central to blood coagulation and an acute-phase reactant. We aimed to identify common variants influencing circulation fibrinogen levels. METHODS AND RESULTS: We conducted a genome-wide association analysis on 6 population-based studies, the Rotterdam Study, the Framingham Heart Study, the Cardiovascular Health Study, the Atherosclerosis Risk in Communities Study, the Monitoring of Trends and Determinants in Cardiovascular Disease/KORA Augsburg Study, and the British 1958 Birth Cohort Study, including 22 096 participants of European ancestry. Four loci were marked by 1 or more single-nucleotide polymorphisms that demonstrated genome-wide significance (P",

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AU - Dehghan, Abbas

AU - Yang, Qiong

AU - Peters, Annette

AU - Basu, Saonli

AU - Bis, Joshua C

AU - Rudnicka, Alicja R

AU - Kavousi, Maryam

AU - Chen, Mei

AU - Baumert, Jens

AU - Lowe, Gordon D O

AU - McKnight, Barbara

AU - Tang, Weihong

AU - de Maat, Moniek

AU - Larson, Marian

AU - Eyhermendy, Susana

AU - McArdle, Wendy L

AU - Lumley, Thomas

AU - Pankow, James S

AU - Hofman, Albert

AU - Massaro, Joseph M

AU - Rivadeneira, Fernando

AU - Kolz, Melanie

AU - Taylor, Kent D.

AU - van Duijn, Cornelia M

AU - Kathiresan, Sekar

AU - Illig, Thomas

AU - Aulchenko, Yurii S

AU - Volcik, Kelly A

AU - Johnson, Andrew D.

AU - Uitterlinden, Andre G

AU - Tofler, Geoffrey H

AU - Gieger, Christian

AU - Psaty, Bruce M

AU - Couper, David J

AU - Boerwinkle, Eric

AU - Koenig, Wolfgang

AU - O'Donnell, Christopher J

AU - Witteman, Jacqueline C

AU - Strachan, David P.

AU - Smith, Nicholas L

AU - Folsom, Aaron R

AU - Wellcome Trust Case Control Consortium

PY - 2009/4/1

Y1 - 2009/4/1

N2 - BACKGROUND: Fibrinogen is both central to blood coagulation and an acute-phase reactant. We aimed to identify common variants influencing circulation fibrinogen levels. METHODS AND RESULTS: We conducted a genome-wide association analysis on 6 population-based studies, the Rotterdam Study, the Framingham Heart Study, the Cardiovascular Health Study, the Atherosclerosis Risk in Communities Study, the Monitoring of Trends and Determinants in Cardiovascular Disease/KORA Augsburg Study, and the British 1958 Birth Cohort Study, including 22 096 participants of European ancestry. Four loci were marked by 1 or more single-nucleotide polymorphisms that demonstrated genome-wide significance (P

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KW - Aged, 80 and over

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KW - Cohort Studies

KW - European Continental Ancestry Group

KW - Female

KW - Fibrinogen

KW - Genetic Loci

KW - Genome-Wide Association Study

KW - Humans

KW - Male

KW - Middle Aged

KW - Pedigree

KW - Polymorphism, Single Nucleotide

KW - Young Adult

KW - genome-wide association study

KW - fibrinogen

KW - genes

KW - meta-analysis

U2 - 10.1161/CIRCGENETICS.108.825224

DO - 10.1161/CIRCGENETICS.108.825224

M3 - Article

C2 - 20031576

SN - 1942-3268

VL - 2

SP - 125

EP - 133

JO - Circulation. Cardiovascular Genetics

JF - Circulation. Cardiovascular Genetics

IS - 2

ER -

Association of novel genetic Loci with circulating fibrinogen levels: a genome-wide association study in 6 population-based cohorts

Abstract

Keywords

UN SDGs

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