Association of novel genetic Loci with circulating fibrinogen levels: a genome-wide association study in 6 population-based cohorts

Abbas Dehghan, Qiong Yang, Annette Peters, Saonli Basu, Joshua C Bis, Alicja R Rudnicka, Maryam Kavousi, Mei Chen, Jens Baumert, Gordon D O Lowe, Barbara McKnight, Weihong Tang, Moniek de Maat, Marian Larson, Susana Eyhermendy, Wendy L McArdle, Thomas Lumley, James S Pankow, Albert Hofman, Joseph M MassaroFernando Rivadeneira, Melanie Kolz, Kent D. Taylor, Cornelia M van Duijn, Sekar Kathiresan, Thomas Illig, Yurii S Aulchenko, Kelly A Volcik, Andrew D. Johnson, Andre G Uitterlinden, Geoffrey H Tofler, Christian Gieger, Bruce M Psaty, David J Couper, Eric Boerwinkle, Wolfgang Koenig, Christopher J O'Donnell, Jacqueline C Witteman, David P. Strachan, Nicholas L Smith, Aaron R Folsom, Wellcome Trust Case Control Consortium

Research output: Contribution to journalArticle

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Abstract

BACKGROUND: Fibrinogen is both central to blood coagulation and an acute-phase reactant. We aimed to identify common variants influencing circulation fibrinogen levels. METHODS AND RESULTS: We conducted a genome-wide association analysis on 6 population-based studies, the Rotterdam Study, the Framingham Heart Study, the Cardiovascular Health Study, the Atherosclerosis Risk in Communities Study, the Monitoring of Trends and Determinants in Cardiovascular Disease/KORA Augsburg Study, and the British 1958 Birth Cohort Study, including 22 096 participants of European ancestry. Four loci were marked by 1 or more single-nucleotide polymorphisms that demonstrated genome-wide significance (P
Original languageEnglish
Pages (from-to)125-133
Number of pages9
JournalCirculation. Cardiovascular Genetics
Volume2
Issue number2
DOIs
Publication statusPublished - 1 Apr 2009

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Genetic Loci
Genome-Wide Association Study
Fibrinogen
Acute-Phase Proteins
Blood Coagulation
Population
Single Nucleotide Polymorphism
Atherosclerosis
Cohort Studies
Cardiovascular Diseases
Parturition
Genome
Health

Keywords

  • Adult
  • Aged
  • Aged, 80 and over
  • Cardiovascular Diseases
  • Cohort Studies
  • European Continental Ancestry Group
  • Female
  • Fibrinogen
  • Genetic Loci
  • Genome-Wide Association Study
  • Humans
  • Male
  • Middle Aged
  • Pedigree
  • Polymorphism, Single Nucleotide
  • Young Adult
  • genome-wide association study
  • fibrinogen
  • genes
  • meta-analysis

Cite this

Dehghan, A., Yang, Q., Peters, A., Basu, S., Bis, J. C., Rudnicka, A. R., ... Wellcome Trust Case Control Consortium (2009). Association of novel genetic Loci with circulating fibrinogen levels: a genome-wide association study in 6 population-based cohorts. Circulation. Cardiovascular Genetics, 2(2), 125-133. https://doi.org/10.1161/CIRCGENETICS.108.825224

Association of novel genetic Loci with circulating fibrinogen levels : a genome-wide association study in 6 population-based cohorts. / Dehghan, Abbas; Yang, Qiong; Peters, Annette; Basu, Saonli; Bis, Joshua C; Rudnicka, Alicja R; Kavousi, Maryam; Chen, Mei; Baumert, Jens; Lowe, Gordon D O; McKnight, Barbara; Tang, Weihong; de Maat, Moniek; Larson, Marian; Eyhermendy, Susana; McArdle, Wendy L; Lumley, Thomas; Pankow, James S; Hofman, Albert; Massaro, Joseph M; Rivadeneira, Fernando; Kolz, Melanie; Taylor, Kent D. ; van Duijn, Cornelia M; Kathiresan, Sekar; Illig, Thomas; Aulchenko, Yurii S; Volcik, Kelly A; Johnson, Andrew D.; Uitterlinden, Andre G; Tofler, Geoffrey H; Gieger, Christian; Psaty, Bruce M; Couper, David J; Boerwinkle, Eric; Koenig, Wolfgang; O'Donnell, Christopher J; Witteman, Jacqueline C; Strachan, David P. ; Smith, Nicholas L; Folsom, Aaron R; Wellcome Trust Case Control Consortium.

In: Circulation. Cardiovascular Genetics, Vol. 2, No. 2, 01.04.2009, p. 125-133.

Research output: Contribution to journalArticle

Dehghan, A, Yang, Q, Peters, A, Basu, S, Bis, JC, Rudnicka, AR, Kavousi, M, Chen, M, Baumert, J, Lowe, GDO, McKnight, B, Tang, W, de Maat, M, Larson, M, Eyhermendy, S, McArdle, WL, Lumley, T, Pankow, JS, Hofman, A, Massaro, JM, Rivadeneira, F, Kolz, M, Taylor, KD, van Duijn, CM, Kathiresan, S, Illig, T, Aulchenko, YS, Volcik, KA, Johnson, AD, Uitterlinden, AG, Tofler, GH, Gieger, C, Psaty, BM, Couper, DJ, Boerwinkle, E, Koenig, W, O'Donnell, CJ, Witteman, JC, Strachan, DP, Smith, NL, Folsom, AR & Wellcome Trust Case Control Consortium 2009, 'Association of novel genetic Loci with circulating fibrinogen levels: a genome-wide association study in 6 population-based cohorts', Circulation. Cardiovascular Genetics, vol. 2, no. 2, pp. 125-133. https://doi.org/10.1161/CIRCGENETICS.108.825224
Dehghan, Abbas ; Yang, Qiong ; Peters, Annette ; Basu, Saonli ; Bis, Joshua C ; Rudnicka, Alicja R ; Kavousi, Maryam ; Chen, Mei ; Baumert, Jens ; Lowe, Gordon D O ; McKnight, Barbara ; Tang, Weihong ; de Maat, Moniek ; Larson, Marian ; Eyhermendy, Susana ; McArdle, Wendy L ; Lumley, Thomas ; Pankow, James S ; Hofman, Albert ; Massaro, Joseph M ; Rivadeneira, Fernando ; Kolz, Melanie ; Taylor, Kent D. ; van Duijn, Cornelia M ; Kathiresan, Sekar ; Illig, Thomas ; Aulchenko, Yurii S ; Volcik, Kelly A ; Johnson, Andrew D. ; Uitterlinden, Andre G ; Tofler, Geoffrey H ; Gieger, Christian ; Psaty, Bruce M ; Couper, David J ; Boerwinkle, Eric ; Koenig, Wolfgang ; O'Donnell, Christopher J ; Witteman, Jacqueline C ; Strachan, David P. ; Smith, Nicholas L ; Folsom, Aaron R ; Wellcome Trust Case Control Consortium. / Association of novel genetic Loci with circulating fibrinogen levels : a genome-wide association study in 6 population-based cohorts. In: Circulation. Cardiovascular Genetics. 2009 ; Vol. 2, No. 2. pp. 125-133.
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AU - Basu, Saonli

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AU - Hofman, Albert

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AU - van Duijn, Cornelia M

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AU - Illig, Thomas

AU - Aulchenko, Yurii S

AU - Volcik, Kelly A

AU - Johnson, Andrew D.

AU - Uitterlinden, Andre G

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AU - Gieger, Christian

AU - Psaty, Bruce M

AU - Couper, David J

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KW - Male

KW - Middle Aged

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KW - Polymorphism, Single Nucleotide

KW - Young Adult

KW - genome-wide association study

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