Association of novel genetic Loci with circulating fibrinogen levels: a genome-wide association study in 6 population-based cohorts

Abbas Dehghan, Qiong Yang, Annette Peters, Saonli Basu, Joshua C Bis, Alicja R Rudnicka, Maryam Kavousi, Mei Chen, Jens Baumert, Gordon D O Lowe, Barbara McKnight, Weihong Tang, Moniek de Maat, Marian Larson, Susana Eyhermendy, Wendy L McArdle, Thomas Lumley, James S Pankow, Albert Hofman, Joseph M MassaroFernando Rivadeneira, Melanie Kolz, Kent D. Taylor, Cornelia M van Duijn, Sekar Kathiresan, Thomas Illig, Yurii S Aulchenko, Kelly A Volcik, Andrew D. Johnson, Andre G Uitterlinden, Geoffrey H Tofler, Christian Gieger, Bruce M Psaty, David J Couper, Eric Boerwinkle, Wolfgang Koenig, Christopher J O'Donnell, Jacqueline C Witteman, David P. Strachan, Nicholas L Smith, Aaron R Folsom, Wellcome Trust Case Control Consortium

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BACKGROUND: Fibrinogen is both central to blood coagulation and an acute-phase reactant. We aimed to identify common variants influencing circulation fibrinogen levels. METHODS AND RESULTS: We conducted a genome-wide association analysis on 6 population-based studies, the Rotterdam Study, the Framingham Heart Study, the Cardiovascular Health Study, the Atherosclerosis Risk in Communities Study, the Monitoring of Trends and Determinants in Cardiovascular Disease/KORA Augsburg Study, and the British 1958 Birth Cohort Study, including 22 096 participants of European ancestry. Four loci were marked by 1 or more single-nucleotide polymorphisms that demonstrated genome-wide significance (P
Original languageEnglish
Pages (from-to)125-133
Number of pages9
JournalCirculation. Cardiovascular Genetics
Issue number2
Publication statusPublished - 1 Apr 2009



  • Adult
  • Aged
  • Aged, 80 and over
  • Cardiovascular Diseases
  • Cohort Studies
  • European Continental Ancestry Group
  • Female
  • Fibrinogen
  • Genetic Loci
  • Genome-Wide Association Study
  • Humans
  • Male
  • Middle Aged
  • Pedigree
  • Polymorphism, Single Nucleotide
  • Young Adult
  • genome-wide association study
  • fibrinogen
  • genes
  • meta-analysis

Cite this

Dehghan, A., Yang, Q., Peters, A., Basu, S., Bis, J. C., Rudnicka, A. R., Kavousi, M., Chen, M., Baumert, J., Lowe, G. D. O., McKnight, B., Tang, W., de Maat, M., Larson, M., Eyhermendy, S., McArdle, W. L., Lumley, T., Pankow, J. S., Hofman, A., ... Wellcome Trust Case Control Consortium (2009). Association of novel genetic Loci with circulating fibrinogen levels: a genome-wide association study in 6 population-based cohorts. Circulation. Cardiovascular Genetics, 2(2), 125-133.