Association of osteoarthritis risk factors with knee and hip pain in a population-based sample of 29-59 year olds in Denmark: A cross-sectional analysis

Joyce A.C. Van Tunen, George Peat, Alessio Bricca, Lars B. Larsen, Jens Søndergaard, Trine Thilsing, Ewa M. Roos, Jonas B. Thorlund*

*Corresponding author for this work

Research output: Contribution to journalArticle

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Abstract

Background: This study aimed to a) describe the prevalence of knee and hip osteoarthritis risk factors in a population of 29-59 year old individuals, b) estimate the association between persistent knee/hip pain and osteoarthritis risk factors, and c) describe the prevalence of osteoarthritis risk factors, including specific biomechanical risk factors, in individuals with prolonged persistent knee or hip pain. Methods: Participants completed the "Early Detection and Prevention" pilot study questionnaire, including items on presence of knee/hip pain within the last month and osteoarthritis risk factors. Individuals reporting knee/hip problems completed a second questionnaire, including items about most problematic joint and specific biomechanical osteoarthritis risk factors. After describing the prevalence of persistent knee/hip pain and osteoarthritis risk factors among respondents stratified for sex and age, logistic regression was used to estimate the strength of associations between osteoarthritis risk factors and presence of knee/hip pain. The prevalence of prolonged persistent pain (i.e. knee/hip pain reported at both questionnaires) and osteoarthritis risk factors among respondents with prolonged persistent knee and hip pain, were described. Results: Two thousand six hundred sixty-one respondents completed the first survey. The one-month prevalence of persistent knee/hip pain was 27%. Previous knee/hip injury was associated with persistent knee/hip pain for both sexes in all age groups, while a family history of osteoarthritis was associated with persistent knee/hip pain in all age groups except for 29-39 year old men. A higher BMI was associated with persistent knee/hip pain in 40-59 year old women, and 50-59 year old men. Eight hundred sixty seven respondents completed the second questionnaire. Knee/hip injuries and surgeries were more common in individuals with prolonged persistent knee than hip pain. Conclusions: Knee/hip pain within the last month was frequent among individuals aged 29-59 years. Multiple known osteoarthritis risk factors were associated with presence of knee/hip pain. Joint injury and previous surgery were more common in individuals with knee than hip pain. The results support the notion that joint injury and overweight during early adulthood are signs of a trajectory towards symptomatic osteoarthritis later in life and may help earlier identification of groups at high risk of future symptomatic osteoarthritis. Trial registration: ClinicalTrials.gov (NCT02797392). Registered April 29,2016.

Original languageEnglish
Article number300
JournalBMC Musculoskeletal Disorders
Volume19
DOIs
Publication statusPublished - 21 Aug 2018

Fingerprint

Denmark
Osteoarthritis
Hip
Knee
Cross-Sectional Studies
Pain
Population
Hip Osteoarthritis
Hip Injuries
Knee Injuries
Joints
Age Groups
Surveys and Questionnaires
Social Identification
Knee Osteoarthritis
Wounds and Injuries

Keywords

  • Hip
  • Knee
  • Osteoarthritis
  • Pain
  • Prevalence
  • Risk factors

ASJC Scopus subject areas

  • Rheumatology
  • Orthopedics and Sports Medicine

Cite this

Association of osteoarthritis risk factors with knee and hip pain in a population-based sample of 29-59 year olds in Denmark : A cross-sectional analysis. / Van Tunen, Joyce A.C.; Peat, George; Bricca, Alessio; Larsen, Lars B.; Søndergaard, Jens; Thilsing, Trine; Roos, Ewa M.; Thorlund, Jonas B.

In: BMC Musculoskeletal Disorders, Vol. 19, 300, 21.08.2018.

Research output: Contribution to journalArticle

Van Tunen, Joyce A.C. ; Peat, George ; Bricca, Alessio ; Larsen, Lars B. ; Søndergaard, Jens ; Thilsing, Trine ; Roos, Ewa M. ; Thorlund, Jonas B. / Association of osteoarthritis risk factors with knee and hip pain in a population-based sample of 29-59 year olds in Denmark : A cross-sectional analysis. In: BMC Musculoskeletal Disorders. 2018 ; Vol. 19.
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abstract = "Background: This study aimed to a) describe the prevalence of knee and hip osteoarthritis risk factors in a population of 29-59 year old individuals, b) estimate the association between persistent knee/hip pain and osteoarthritis risk factors, and c) describe the prevalence of osteoarthritis risk factors, including specific biomechanical risk factors, in individuals with prolonged persistent knee or hip pain. Methods: Participants completed the {"}Early Detection and Prevention{"} pilot study questionnaire, including items on presence of knee/hip pain within the last month and osteoarthritis risk factors. Individuals reporting knee/hip problems completed a second questionnaire, including items about most problematic joint and specific biomechanical osteoarthritis risk factors. After describing the prevalence of persistent knee/hip pain and osteoarthritis risk factors among respondents stratified for sex and age, logistic regression was used to estimate the strength of associations between osteoarthritis risk factors and presence of knee/hip pain. The prevalence of prolonged persistent pain (i.e. knee/hip pain reported at both questionnaires) and osteoarthritis risk factors among respondents with prolonged persistent knee and hip pain, were described. Results: Two thousand six hundred sixty-one respondents completed the first survey. The one-month prevalence of persistent knee/hip pain was 27{\%}. Previous knee/hip injury was associated with persistent knee/hip pain for both sexes in all age groups, while a family history of osteoarthritis was associated with persistent knee/hip pain in all age groups except for 29-39 year old men. A higher BMI was associated with persistent knee/hip pain in 40-59 year old women, and 50-59 year old men. Eight hundred sixty seven respondents completed the second questionnaire. Knee/hip injuries and surgeries were more common in individuals with prolonged persistent knee than hip pain. Conclusions: Knee/hip pain within the last month was frequent among individuals aged 29-59 years. Multiple known osteoarthritis risk factors were associated with presence of knee/hip pain. Joint injury and previous surgery were more common in individuals with knee than hip pain. The results support the notion that joint injury and overweight during early adulthood are signs of a trajectory towards symptomatic osteoarthritis later in life and may help earlier identification of groups at high risk of future symptomatic osteoarthritis. Trial registration: ClinicalTrials.gov (NCT02797392). Registered April 29,2016.",
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note = "The TOF pilot study was funded by a grant from the Region of Southern Denmark: 11/13244, and grants from The Committee of Quality and Education in General Practice, The Region of Southern Denmark: J.nr 15/10562 and 14/43732. Joyce van Tunen was funded by the European Union Seventh Framework Programme (FP7-PEOPLE-2013-ITN;KNEEMO) under grant agreement no. 607510. The funding bodies had no role in the design of the study and collection, analysis, and interpretation of data and in writing the manuscript.",
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TY - JOUR

T1 - Association of osteoarthritis risk factors with knee and hip pain in a population-based sample of 29-59 year olds in Denmark

T2 - A cross-sectional analysis

AU - Van Tunen, Joyce A.C.

AU - Peat, George

AU - Bricca, Alessio

AU - Larsen, Lars B.

AU - Søndergaard, Jens

AU - Thilsing, Trine

AU - Roos, Ewa M.

AU - Thorlund, Jonas B.

N1 - The TOF pilot study was funded by a grant from the Region of Southern Denmark: 11/13244, and grants from The Committee of Quality and Education in General Practice, The Region of Southern Denmark: J.nr 15/10562 and 14/43732. Joyce van Tunen was funded by the European Union Seventh Framework Programme (FP7-PEOPLE-2013-ITN;KNEEMO) under grant agreement no. 607510. The funding bodies had no role in the design of the study and collection, analysis, and interpretation of data and in writing the manuscript.

PY - 2018/8/21

Y1 - 2018/8/21

N2 - Background: This study aimed to a) describe the prevalence of knee and hip osteoarthritis risk factors in a population of 29-59 year old individuals, b) estimate the association between persistent knee/hip pain and osteoarthritis risk factors, and c) describe the prevalence of osteoarthritis risk factors, including specific biomechanical risk factors, in individuals with prolonged persistent knee or hip pain. Methods: Participants completed the "Early Detection and Prevention" pilot study questionnaire, including items on presence of knee/hip pain within the last month and osteoarthritis risk factors. Individuals reporting knee/hip problems completed a second questionnaire, including items about most problematic joint and specific biomechanical osteoarthritis risk factors. After describing the prevalence of persistent knee/hip pain and osteoarthritis risk factors among respondents stratified for sex and age, logistic regression was used to estimate the strength of associations between osteoarthritis risk factors and presence of knee/hip pain. The prevalence of prolonged persistent pain (i.e. knee/hip pain reported at both questionnaires) and osteoarthritis risk factors among respondents with prolonged persistent knee and hip pain, were described. Results: Two thousand six hundred sixty-one respondents completed the first survey. The one-month prevalence of persistent knee/hip pain was 27%. Previous knee/hip injury was associated with persistent knee/hip pain for both sexes in all age groups, while a family history of osteoarthritis was associated with persistent knee/hip pain in all age groups except for 29-39 year old men. A higher BMI was associated with persistent knee/hip pain in 40-59 year old women, and 50-59 year old men. Eight hundred sixty seven respondents completed the second questionnaire. Knee/hip injuries and surgeries were more common in individuals with prolonged persistent knee than hip pain. Conclusions: Knee/hip pain within the last month was frequent among individuals aged 29-59 years. Multiple known osteoarthritis risk factors were associated with presence of knee/hip pain. Joint injury and previous surgery were more common in individuals with knee than hip pain. The results support the notion that joint injury and overweight during early adulthood are signs of a trajectory towards symptomatic osteoarthritis later in life and may help earlier identification of groups at high risk of future symptomatic osteoarthritis. Trial registration: ClinicalTrials.gov (NCT02797392). Registered April 29,2016.

AB - Background: This study aimed to a) describe the prevalence of knee and hip osteoarthritis risk factors in a population of 29-59 year old individuals, b) estimate the association between persistent knee/hip pain and osteoarthritis risk factors, and c) describe the prevalence of osteoarthritis risk factors, including specific biomechanical risk factors, in individuals with prolonged persistent knee or hip pain. Methods: Participants completed the "Early Detection and Prevention" pilot study questionnaire, including items on presence of knee/hip pain within the last month and osteoarthritis risk factors. Individuals reporting knee/hip problems completed a second questionnaire, including items about most problematic joint and specific biomechanical osteoarthritis risk factors. After describing the prevalence of persistent knee/hip pain and osteoarthritis risk factors among respondents stratified for sex and age, logistic regression was used to estimate the strength of associations between osteoarthritis risk factors and presence of knee/hip pain. The prevalence of prolonged persistent pain (i.e. knee/hip pain reported at both questionnaires) and osteoarthritis risk factors among respondents with prolonged persistent knee and hip pain, were described. Results: Two thousand six hundred sixty-one respondents completed the first survey. The one-month prevalence of persistent knee/hip pain was 27%. Previous knee/hip injury was associated with persistent knee/hip pain for both sexes in all age groups, while a family history of osteoarthritis was associated with persistent knee/hip pain in all age groups except for 29-39 year old men. A higher BMI was associated with persistent knee/hip pain in 40-59 year old women, and 50-59 year old men. Eight hundred sixty seven respondents completed the second questionnaire. Knee/hip injuries and surgeries were more common in individuals with prolonged persistent knee than hip pain. Conclusions: Knee/hip pain within the last month was frequent among individuals aged 29-59 years. Multiple known osteoarthritis risk factors were associated with presence of knee/hip pain. Joint injury and previous surgery were more common in individuals with knee than hip pain. The results support the notion that joint injury and overweight during early adulthood are signs of a trajectory towards symptomatic osteoarthritis later in life and may help earlier identification of groups at high risk of future symptomatic osteoarthritis. Trial registration: ClinicalTrials.gov (NCT02797392). Registered April 29,2016.

KW - Hip

KW - Knee

KW - Osteoarthritis

KW - Pain

KW - Prevalence

KW - Risk factors

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U2 - 10.1186/s12891-018-2183-7

DO - 10.1186/s12891-018-2183-7

M3 - Article

AN - SCOPUS:85052070910

VL - 19

JO - BMC Musculoskeletal Disorders

JF - BMC Musculoskeletal Disorders

SN - 1471-2474

M1 - 300

ER -