Association of sugar sweetened beverages consumption with non-alcoholic fatty liver disease: a systematic review and meta-analysis

Farzaneh Asgari-Taee, Nahid Zerafati-Shoae, Mohsen Dehghani, Masoumeh Sadeghi (Corresponding Author), Hamid R. Baradaran, Shima Jazayeri

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Purpose: The relationship between consumption of sugar sweetened beverages (SSB) and NAFLD has been reported in several epidemiological studies, but the results are inconsistent. The present systematic review and meta-analysis of observational studies was carried out to assess the relationship between sugar sweetened beverages consumption and NAFLD. Methods: Online databases were searched systematically through December, 2016 for studies investigating association between SSB consumption and NAFLD but limited to observational studies in human. Pooled odds ratio (OR) and 95% confidence intervals were calculated using Der-Simonian and Laird method while random effects meta-analysis was used, taking into account conceptual heterogeneity. Heterogeneity was assessed with the Cochran Q statistic and quantified with the I2 statistic. Results: Of the 1015 identified articles, 42 were reviewed in depth and six studies (four cross-sectional, one case–control, and one cohort) met the criteria for inclusion in our systematic review with 6326 participants and 1361 cases of NAFLD in both men and women. Finally, four cross-sectional studies were included in the meta-analysis. Higher intake of SSBs (highest compared to lowest categories) was significantly associated with NAFLD, with a 40% increased Odds of NAFLD after adjusting for important potential confounders (pooled odds ratio 1.40; 95% CI 1.07, 1.82). There was no evidence for significant heterogeneity across studies [P = 0.226 (Q statistics), I2 = 31.0%]. A significant positive association between SSB consumption and NAFLD was observed consistently in a sensitivity analysis [range of summary ORs 1.39–1.49]. There was no evidence of publication bias for the association between SSB and NAFLD. Conclusions: This meta-analysis supports a positive significant association between higher consumption of SSB and NAFLD in both men and women. These findings strengthen the evidence that intake of SSBs should be limited to reduce fatty liver disease.

Original languageEnglish
Pages (from-to)1759-1769
Number of pages11
JournalEuropean Journal of Nutrition
Volume58
Issue number5
Early online date14 May 2018
DOIs
Publication statusPublished - Aug 2019

Fingerprint

Beverages
Meta-Analysis
Observational Studies
Cross-Sectional Studies
Odds Ratio
Non-alcoholic Fatty Liver Disease
Publication Bias
Fatty Liver
Liver Diseases
Epidemiologic Studies
Databases
Confidence Intervals

Keywords

  • Meta-analysis
  • NAFLD
  • Risk factors
  • Sugar-sweetened beverage
  • METABOLIC SYNDROME
  • RISK
  • PREVALENCE
  • NATURAL-HISTORY
  • OBESITY
  • DRINKS
  • FRUCTOSE CONSUMPTION
  • EPIDEMIOLOGY
  • US

ASJC Scopus subject areas

  • Nutrition and Dietetics
  • Medicine (miscellaneous)

Cite this

Association of sugar sweetened beverages consumption with non-alcoholic fatty liver disease : a systematic review and meta-analysis. / Asgari-Taee, Farzaneh; Zerafati-Shoae, Nahid; Dehghani, Mohsen; Sadeghi, Masoumeh (Corresponding Author); Baradaran, Hamid R.; Jazayeri, Shima.

In: European Journal of Nutrition, Vol. 58, No. 5, 08.2019, p. 1759-1769.

Research output: Contribution to journalArticle

Asgari-Taee, Farzaneh ; Zerafati-Shoae, Nahid ; Dehghani, Mohsen ; Sadeghi, Masoumeh ; Baradaran, Hamid R. ; Jazayeri, Shima. / Association of sugar sweetened beverages consumption with non-alcoholic fatty liver disease : a systematic review and meta-analysis. In: European Journal of Nutrition. 2019 ; Vol. 58, No. 5. pp. 1759-1769.
@article{f518caf823b544d5bf7d03edcc5418e9,
title = "Association of sugar sweetened beverages consumption with non-alcoholic fatty liver disease: a systematic review and meta-analysis",
abstract = "Purpose: The relationship between consumption of sugar sweetened beverages (SSB) and NAFLD has been reported in several epidemiological studies, but the results are inconsistent. The present systematic review and meta-analysis of observational studies was carried out to assess the relationship between sugar sweetened beverages consumption and NAFLD. Methods: Online databases were searched systematically through December, 2016 for studies investigating association between SSB consumption and NAFLD but limited to observational studies in human. Pooled odds ratio (OR) and 95{\%} confidence intervals were calculated using Der-Simonian and Laird method while random effects meta-analysis was used, taking into account conceptual heterogeneity. Heterogeneity was assessed with the Cochran Q statistic and quantified with the I2 statistic. Results: Of the 1015 identified articles, 42 were reviewed in depth and six studies (four cross-sectional, one case–control, and one cohort) met the criteria for inclusion in our systematic review with 6326 participants and 1361 cases of NAFLD in both men and women. Finally, four cross-sectional studies were included in the meta-analysis. Higher intake of SSBs (highest compared to lowest categories) was significantly associated with NAFLD, with a 40{\%} increased Odds of NAFLD after adjusting for important potential confounders (pooled odds ratio 1.40; 95{\%} CI 1.07, 1.82). There was no evidence for significant heterogeneity across studies [P = 0.226 (Q statistics), I2 = 31.0{\%}]. A significant positive association between SSB consumption and NAFLD was observed consistently in a sensitivity analysis [range of summary ORs 1.39–1.49]. There was no evidence of publication bias for the association between SSB and NAFLD. Conclusions: This meta-analysis supports a positive significant association between higher consumption of SSB and NAFLD in both men and women. These findings strengthen the evidence that intake of SSBs should be limited to reduce fatty liver disease.",
keywords = "Meta-analysis, NAFLD, Risk factors, Sugar-sweetened beverage, METABOLIC SYNDROME, RISK, PREVALENCE, NATURAL-HISTORY, OBESITY, DRINKS, FRUCTOSE CONSUMPTION, EPIDEMIOLOGY, US",
author = "Farzaneh Asgari-Taee and Nahid Zerafati-Shoae and Mohsen Dehghani and Masoumeh Sadeghi and Baradaran, {Hamid R.} and Shima Jazayeri",
note = "This study was partly supported by funds from Vice-Chancellor for Research of Iran University of Medical Sciences (IUMS), Tehran, Iran (Grant no. 96-02-27-29952). The funding sources had no role in study design, data collection, analysis, interpretation, and preparation of the manuscript.",
year = "2019",
month = "8",
doi = "10.1007/s00394-018-1711-4",
language = "English",
volume = "58",
pages = "1759--1769",
journal = "European Journal of Nutrition",
issn = "1436-6207",
publisher = "D. Steinkopff-Verlag",
number = "5",

}

TY - JOUR

T1 - Association of sugar sweetened beverages consumption with non-alcoholic fatty liver disease

T2 - a systematic review and meta-analysis

AU - Asgari-Taee, Farzaneh

AU - Zerafati-Shoae, Nahid

AU - Dehghani, Mohsen

AU - Sadeghi, Masoumeh

AU - Baradaran, Hamid R.

AU - Jazayeri, Shima

N1 - This study was partly supported by funds from Vice-Chancellor for Research of Iran University of Medical Sciences (IUMS), Tehran, Iran (Grant no. 96-02-27-29952). The funding sources had no role in study design, data collection, analysis, interpretation, and preparation of the manuscript.

PY - 2019/8

Y1 - 2019/8

N2 - Purpose: The relationship between consumption of sugar sweetened beverages (SSB) and NAFLD has been reported in several epidemiological studies, but the results are inconsistent. The present systematic review and meta-analysis of observational studies was carried out to assess the relationship between sugar sweetened beverages consumption and NAFLD. Methods: Online databases were searched systematically through December, 2016 for studies investigating association between SSB consumption and NAFLD but limited to observational studies in human. Pooled odds ratio (OR) and 95% confidence intervals were calculated using Der-Simonian and Laird method while random effects meta-analysis was used, taking into account conceptual heterogeneity. Heterogeneity was assessed with the Cochran Q statistic and quantified with the I2 statistic. Results: Of the 1015 identified articles, 42 were reviewed in depth and six studies (four cross-sectional, one case–control, and one cohort) met the criteria for inclusion in our systematic review with 6326 participants and 1361 cases of NAFLD in both men and women. Finally, four cross-sectional studies were included in the meta-analysis. Higher intake of SSBs (highest compared to lowest categories) was significantly associated with NAFLD, with a 40% increased Odds of NAFLD after adjusting for important potential confounders (pooled odds ratio 1.40; 95% CI 1.07, 1.82). There was no evidence for significant heterogeneity across studies [P = 0.226 (Q statistics), I2 = 31.0%]. A significant positive association between SSB consumption and NAFLD was observed consistently in a sensitivity analysis [range of summary ORs 1.39–1.49]. There was no evidence of publication bias for the association between SSB and NAFLD. Conclusions: This meta-analysis supports a positive significant association between higher consumption of SSB and NAFLD in both men and women. These findings strengthen the evidence that intake of SSBs should be limited to reduce fatty liver disease.

AB - Purpose: The relationship between consumption of sugar sweetened beverages (SSB) and NAFLD has been reported in several epidemiological studies, but the results are inconsistent. The present systematic review and meta-analysis of observational studies was carried out to assess the relationship between sugar sweetened beverages consumption and NAFLD. Methods: Online databases were searched systematically through December, 2016 for studies investigating association between SSB consumption and NAFLD but limited to observational studies in human. Pooled odds ratio (OR) and 95% confidence intervals were calculated using Der-Simonian and Laird method while random effects meta-analysis was used, taking into account conceptual heterogeneity. Heterogeneity was assessed with the Cochran Q statistic and quantified with the I2 statistic. Results: Of the 1015 identified articles, 42 were reviewed in depth and six studies (four cross-sectional, one case–control, and one cohort) met the criteria for inclusion in our systematic review with 6326 participants and 1361 cases of NAFLD in both men and women. Finally, four cross-sectional studies were included in the meta-analysis. Higher intake of SSBs (highest compared to lowest categories) was significantly associated with NAFLD, with a 40% increased Odds of NAFLD after adjusting for important potential confounders (pooled odds ratio 1.40; 95% CI 1.07, 1.82). There was no evidence for significant heterogeneity across studies [P = 0.226 (Q statistics), I2 = 31.0%]. A significant positive association between SSB consumption and NAFLD was observed consistently in a sensitivity analysis [range of summary ORs 1.39–1.49]. There was no evidence of publication bias for the association between SSB and NAFLD. Conclusions: This meta-analysis supports a positive significant association between higher consumption of SSB and NAFLD in both men and women. These findings strengthen the evidence that intake of SSBs should be limited to reduce fatty liver disease.

KW - Meta-analysis

KW - NAFLD

KW - Risk factors

KW - Sugar-sweetened beverage

KW - METABOLIC SYNDROME

KW - RISK

KW - PREVALENCE

KW - NATURAL-HISTORY

KW - OBESITY

KW - DRINKS

KW - FRUCTOSE CONSUMPTION

KW - EPIDEMIOLOGY

KW - US

UR - http://www.scopus.com/inward/record.url?scp=85046893967&partnerID=8YFLogxK

UR - http://www.mendeley.com/research/association-sugar-sweetened-beverages-consumption-nonalcoholic-fatty-liver-disease-systematic-review

UR - https://abdn.pure.elsevier.com/en/en/researchoutput/association-of-sugar-sweetened-beverages-consumption-with-nonalcoholic-fatty-liver-disease(f518caf8-23b5-44d5-bf7d-03edcc5418e9).html

U2 - 10.1007/s00394-018-1711-4

DO - 10.1007/s00394-018-1711-4

M3 - Article

VL - 58

SP - 1759

EP - 1769

JO - European Journal of Nutrition

JF - European Journal of Nutrition

SN - 1436-6207

IS - 5

ER -