Association of the AFF3 gene and IL2/IL21 gene region with juvenile idiopathic arthritis

A Hinks, S Eyre, X Ke, A Barton, P Martin, E Flynn, J Packham, J Worthington, W Thomson, UK Rheumatoid Arthritis Genetics Consortium

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Abstract

Recent genetic studies have led to identification of numerous loci that are associated with susceptibility to autoimmune diseases. The strategy of using information from these studies has facilitated the identification of novel juvenile idiopathic arthritis (JIA) susceptibility loci, specifically, PTPN22 and IL2RA. Several novel autoimmune susceptibility loci have recently been identified, and we hypothesise that single-nucleotide polymorphisms (SNPs) within these genes may also be JIA susceptibility loci. Five SNPs within the genes AFF3, IL2/IL21, IL7R, CTLA4 and CD226, previously associated with multiple autoimmune diseases were genotyped, in a large data set of Caucasian JIA patients and controls, and tested for association with JIA. We identified two susceptibility loci for JIA, AFF3 and the IL2/IL21 region and additional weak evidence supporting an association with the CTLA4 and IL7R genes, which warrant further investigation. All results require validation in independent JIA data sets. Further characterisation of the specific causal variants will be required before functional studies can be performed.
Original languageEnglish
Pages (from-to)194-198
Number of pages5
JournalGenes and Immunity
Volume11
Issue number2
Early online date14 Jan 2010
DOIs
Publication statusPublished - Mar 2010

Keywords

  • autoimmune
  • juvenile idiopathic arthritis
  • CTLA4
  • AFF3
  • IL2

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    Hinks, A., Eyre, S., Ke, X., Barton, A., Martin, P., Flynn, E., Packham, J., Worthington, J., Thomson, W., & UK Rheumatoid Arthritis Genetics Consortium (2010). Association of the AFF3 gene and IL2/IL21 gene region with juvenile idiopathic arthritis. Genes and Immunity, 11(2), 194-198. https://doi.org/10.1038/gene.2009.105