Association of the dysbindin gene with bipolar affective disorder

Gerome Breen, Diana Prata, Sarah Osborne, Janet Munro, Maggie Sinclair, Tao Li, Susan Staddon, David Dempster, Ricardo Sainz, Barbara Arroyo, Robert W. Kerwin, David St. Clair, David Collier*

*Corresponding author for this work

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

Objective: In the study of bipolar affective disorder and schizophrenia, there is some evidence suggesting a phenotypic and genetic overlap between the two disorders. A possible link between bipolar affective disorder and schizophrenia remains arguable, however. The authors hypothesized that dysbindin, which is a probable susceptibility gene for schizophrenia, was associated with bipolar affective disorder and tested this hypothesis using a case-control design study. Method: Participants included 213 patients with bipolar I disorder and 197 comparison subjects. In each subject, 10 polymorphisms in the dysbindin gene were genotyped and assessed. Results: Two polymorphisms showed individual genotypic association with bipolar I disorder. Multiple marker haplotypes were more strongly associated, with the rarer of the two common haplotypes being overrepresented in the patients with bipolar affective disorder. A similar finding was reported in patients with schizophrenia in a previous study. Conclusions: Findings suggest that the human dysbindin gene may play a role in the susceptibility to bipolar affective disorder, which underscores a potentially important area of etiological overlap with schizophrenia. The existence of shared genetic risk factors will, in time, lead to changes in the current nosology of major psychoses.

Original languageEnglish
Pages (from-to)1636-1638
Number of pages3
JournalAmerican Journal of Psychiatry
Volume163
Issue number9
DOIs
Publication statusPublished - Sep 2006

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