Association of the dysbindin gene with bipolar affective disorder

Gerome Breen, Diana Prata, Sarah Osborne, Janet Munro, Maggie Sinclair, Tao Li, Susan Staddon, David Dempster, Ricardo Sainz, Barbara Arroyo, Robert W. Kerwin, David St. Clair, David Collier*

*Corresponding author for this work

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

Objective: In the study of bipolar affective disorder and schizophrenia, there is some evidence suggesting a phenotypic and genetic overlap between the two disorders. A possible link between bipolar affective disorder and schizophrenia remains arguable, however. The authors hypothesized that dysbindin, which is a probable susceptibility gene for schizophrenia, was associated with bipolar affective disorder and tested this hypothesis using a case-control design study. Method: Participants included 213 patients with bipolar I disorder and 197 comparison subjects. In each subject, 10 polymorphisms in the dysbindin gene were genotyped and assessed. Results: Two polymorphisms showed individual genotypic association with bipolar I disorder. Multiple marker haplotypes were more strongly associated, with the rarer of the two common haplotypes being overrepresented in the patients with bipolar affective disorder. A similar finding was reported in patients with schizophrenia in a previous study. Conclusions: Findings suggest that the human dysbindin gene may play a role in the susceptibility to bipolar affective disorder, which underscores a potentially important area of etiological overlap with schizophrenia. The existence of shared genetic risk factors will, in time, lead to changes in the current nosology of major psychoses.

Original languageEnglish
Pages (from-to)1636-1638
Number of pages3
JournalAmerican Journal of Psychiatry
Volume163
Issue number9
DOIs
Publication statusPublished - Sep 2006

Fingerprint

Mood Disorders
Bipolar Disorder
Schizophrenia
Genes
Haplotypes
Psychotic Disorders
Case-Control Studies

ASJC Scopus subject areas

  • Psychiatry and Mental health

Cite this

Breen, G., Prata, D., Osborne, S., Munro, J., Sinclair, M., Li, T., ... Collier, D. (2006). Association of the dysbindin gene with bipolar affective disorder. American Journal of Psychiatry, 163(9), 1636-1638. https://doi.org/10.1176/appi.ajp.163.9.1636

Association of the dysbindin gene with bipolar affective disorder. / Breen, Gerome; Prata, Diana; Osborne, Sarah; Munro, Janet; Sinclair, Maggie; Li, Tao; Staddon, Susan; Dempster, David; Sainz, Ricardo; Arroyo, Barbara; Kerwin, Robert W.; St. Clair, David; Collier, David.

In: American Journal of Psychiatry, Vol. 163, No. 9, 09.2006, p. 1636-1638.

Research output: Contribution to journalArticle

Breen, G, Prata, D, Osborne, S, Munro, J, Sinclair, M, Li, T, Staddon, S, Dempster, D, Sainz, R, Arroyo, B, Kerwin, RW, St. Clair, D & Collier, D 2006, 'Association of the dysbindin gene with bipolar affective disorder', American Journal of Psychiatry, vol. 163, no. 9, pp. 1636-1638. https://doi.org/10.1176/appi.ajp.163.9.1636
Breen G, Prata D, Osborne S, Munro J, Sinclair M, Li T et al. Association of the dysbindin gene with bipolar affective disorder. American Journal of Psychiatry. 2006 Sep;163(9):1636-1638. https://doi.org/10.1176/appi.ajp.163.9.1636
Breen, Gerome ; Prata, Diana ; Osborne, Sarah ; Munro, Janet ; Sinclair, Maggie ; Li, Tao ; Staddon, Susan ; Dempster, David ; Sainz, Ricardo ; Arroyo, Barbara ; Kerwin, Robert W. ; St. Clair, David ; Collier, David. / Association of the dysbindin gene with bipolar affective disorder. In: American Journal of Psychiatry. 2006 ; Vol. 163, No. 9. pp. 1636-1638.
@article{71ad83b03b364ec6b41c937e0f2ad1fe,
title = "Association of the dysbindin gene with bipolar affective disorder",
abstract = "Objective: In the study of bipolar affective disorder and schizophrenia, there is some evidence suggesting a phenotypic and genetic overlap between the two disorders. A possible link between bipolar affective disorder and schizophrenia remains arguable, however. The authors hypothesized that dysbindin, which is a probable susceptibility gene for schizophrenia, was associated with bipolar affective disorder and tested this hypothesis using a case-control design study. Method: Participants included 213 patients with bipolar I disorder and 197 comparison subjects. In each subject, 10 polymorphisms in the dysbindin gene were genotyped and assessed. Results: Two polymorphisms showed individual genotypic association with bipolar I disorder. Multiple marker haplotypes were more strongly associated, with the rarer of the two common haplotypes being overrepresented in the patients with bipolar affective disorder. A similar finding was reported in patients with schizophrenia in a previous study. Conclusions: Findings suggest that the human dysbindin gene may play a role in the susceptibility to bipolar affective disorder, which underscores a potentially important area of etiological overlap with schizophrenia. The existence of shared genetic risk factors will, in time, lead to changes in the current nosology of major psychoses.",
author = "Gerome Breen and Diana Prata and Sarah Osborne and Janet Munro and Maggie Sinclair and Tao Li and Susan Staddon and David Dempster and Ricardo Sainz and Barbara Arroyo and Kerwin, {Robert W.} and {St. Clair}, David and David Collier",
year = "2006",
month = "9",
doi = "10.1176/appi.ajp.163.9.1636",
language = "English",
volume = "163",
pages = "1636--1638",
journal = "American Journal of Psychiatry",
issn = "0002-953X",
publisher = "American Psychiatric Association",
number = "9",

}

TY - JOUR

T1 - Association of the dysbindin gene with bipolar affective disorder

AU - Breen, Gerome

AU - Prata, Diana

AU - Osborne, Sarah

AU - Munro, Janet

AU - Sinclair, Maggie

AU - Li, Tao

AU - Staddon, Susan

AU - Dempster, David

AU - Sainz, Ricardo

AU - Arroyo, Barbara

AU - Kerwin, Robert W.

AU - St. Clair, David

AU - Collier, David

PY - 2006/9

Y1 - 2006/9

N2 - Objective: In the study of bipolar affective disorder and schizophrenia, there is some evidence suggesting a phenotypic and genetic overlap between the two disorders. A possible link between bipolar affective disorder and schizophrenia remains arguable, however. The authors hypothesized that dysbindin, which is a probable susceptibility gene for schizophrenia, was associated with bipolar affective disorder and tested this hypothesis using a case-control design study. Method: Participants included 213 patients with bipolar I disorder and 197 comparison subjects. In each subject, 10 polymorphisms in the dysbindin gene were genotyped and assessed. Results: Two polymorphisms showed individual genotypic association with bipolar I disorder. Multiple marker haplotypes were more strongly associated, with the rarer of the two common haplotypes being overrepresented in the patients with bipolar affective disorder. A similar finding was reported in patients with schizophrenia in a previous study. Conclusions: Findings suggest that the human dysbindin gene may play a role in the susceptibility to bipolar affective disorder, which underscores a potentially important area of etiological overlap with schizophrenia. The existence of shared genetic risk factors will, in time, lead to changes in the current nosology of major psychoses.

AB - Objective: In the study of bipolar affective disorder and schizophrenia, there is some evidence suggesting a phenotypic and genetic overlap between the two disorders. A possible link between bipolar affective disorder and schizophrenia remains arguable, however. The authors hypothesized that dysbindin, which is a probable susceptibility gene for schizophrenia, was associated with bipolar affective disorder and tested this hypothesis using a case-control design study. Method: Participants included 213 patients with bipolar I disorder and 197 comparison subjects. In each subject, 10 polymorphisms in the dysbindin gene were genotyped and assessed. Results: Two polymorphisms showed individual genotypic association with bipolar I disorder. Multiple marker haplotypes were more strongly associated, with the rarer of the two common haplotypes being overrepresented in the patients with bipolar affective disorder. A similar finding was reported in patients with schizophrenia in a previous study. Conclusions: Findings suggest that the human dysbindin gene may play a role in the susceptibility to bipolar affective disorder, which underscores a potentially important area of etiological overlap with schizophrenia. The existence of shared genetic risk factors will, in time, lead to changes in the current nosology of major psychoses.

UR - http://www.scopus.com/inward/record.url?scp=33749076012&partnerID=8YFLogxK

U2 - 10.1176/appi.ajp.163.9.1636

DO - 10.1176/appi.ajp.163.9.1636

M3 - Article

C2 - 16946192

AN - SCOPUS:33749076012

VL - 163

SP - 1636

EP - 1638

JO - American Journal of Psychiatry

JF - American Journal of Psychiatry

SN - 0002-953X

IS - 9

ER -