Association of tumor necrosis factor-α -308 G/A gene polymorphism with coronary artery diseases: An evidence-based study

Elaheh Kazemi, Khadijeh Jamialahmadi, Amir Avan, Seyed Reza Mirhafez, Javad Mohiti, Maryam Pirhoushiaran, Nedasadat Hosseini, Akram Mohammadi, Gordon A. Ferns, Alireza Pasdar*, Majid Ghayour-Mobarhan

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

Background: Coronary artery disease (CAD) is the leading cause of death worldwide and remains a major health problem, providing the rationale for identification of molecular markers for detection of individuals at high risk of developing CAD. Tumor necrosis factor-α (TNF-α) plays a crucial role in the pathogenesis of CAD. We have therefore explored the association of TNF-α 308 (G/A) gene polymorphism in 903 individuals with/without CAD. Methods: TNF-α 308 gene polymorphism was analyzed in 903 subjects of whom 222 were healthy controls. Among the 681 patients who were investigated angiographically, 468 had ≧50% stenosis and 213 patients had <50% stenosis. Biochemical profiles (eg, triglycerides, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, fasting blood glucose, and CRP) were evaluated. Associations between TNF-α genotypes with biochemical and anthropometric characteristics were determined. Results: The frequencies of TNF-α-AA or AG genotypes were significantly lower in patients classified as CAD patients with ≥ or <50% obstruction in at least one coronary artery, compared to the control group. We observed that CAD patients with ≥50% stenosis and with AA genotype were associated with higher risk of CAD with OR of 3.56 (95%CI: 1.02-12.41; P=.046) using multivariate analysis. Moreover, we found that TNF-α-308-AA genotype was associated with blood pressure and CRP level in CAD patients, compared to the wild type-genotype. Conclusion: Our data showed an association of TNF-α-308G/A polymorphism with CAD patients with ≥50% obstruction, supporting the need for further investigations on the role of TNF-α-308G/A polymorphism with hypertension.

Original languageEnglish
Article numbere22153
Number of pages7
JournalJournal of Clinical Laboratory Analysis
Volume32
Issue number1
Early online date23 Feb 2017
DOIs
Publication statusPublished - Jan 2018

Keywords

  • coronary artery disease
  • genotype
  • tumor necrosis factor-α

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