Association study of a (TG)n dinucleotide repeat at chromosome 15q13.3 and schizophrenia in the Chinese population

Jie Ma, Jin-Bo Fan, Li Bian, Chang-Shun Zhang, Xing-Wang Li, Niu-Fan Gu, Guo-Yin Feng, David Malcolm St Clair, Lin He

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Linkage studies have suggested that chromosome 15q13-q14 may harbor a susceptibility locus for schizophrenia. In the current study, the association between a (TG)n dinucleotide repeat polymorphism at D15S976 and schizophrenia was investigated using two independent samples from the Han Chinese population. In a population-based study, no significant difference was found between the genotype and allele frequency distributions in schizophrenia patients and control subjects. In a family-based study, no significant transmission disequilibrium from heterozygous parents to affected offspring was observed. Further analysis of the parent-of-origin effect found nominally significant allele-wise transmission disequilibrium through maternal transmissions, while 157bp and 159bp alleles showed significant individual allelic transmission disequilibrium from heterozygous mothers to affected offspring. Our results did not support the hypothesis that the (TG)n dinucleotide repeat polymorphism plays a major role in schizophrenia susceptibility in the Chinese population. Further studies are needed to elucidate the putative parent-of-origin effect and its role in schizophrenia susceptibility. (C) 2007 Elsevier Ireland Ltd. All rights reserved.

Original languageEnglish
Pages (from-to)245-249
Number of pages5
JournalPsychiatry Research
Volume159
Issue number1-2
DOIs
Publication statusPublished - 30 May 2008

Keywords

  • schizophrenia
  • association
  • TDT
  • CHRNA7
  • CHRFAM7A
  • receptor subunit gene
  • linkage disequilibrium
  • no evidence
  • locus
  • region
  • variants
  • duplication
  • 15Q13-Q14
  • families/

Cite this

Association study of a (TG)n dinucleotide repeat at chromosome 15q13.3 and schizophrenia in the Chinese population. / Ma, Jie; Fan, Jin-Bo; Bian, Li; Zhang, Chang-Shun; Li, Xing-Wang; Gu, Niu-Fan; Feng, Guo-Yin; St Clair, David Malcolm; He, Lin.

In: Psychiatry Research, Vol. 159, No. 1-2, 30.05.2008, p. 245-249.

Research output: Contribution to journalArticle

Ma, Jie ; Fan, Jin-Bo ; Bian, Li ; Zhang, Chang-Shun ; Li, Xing-Wang ; Gu, Niu-Fan ; Feng, Guo-Yin ; St Clair, David Malcolm ; He, Lin. / Association study of a (TG)n dinucleotide repeat at chromosome 15q13.3 and schizophrenia in the Chinese population. In: Psychiatry Research. 2008 ; Vol. 159, No. 1-2. pp. 245-249.
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AU - Gu, Niu-Fan

AU - Feng, Guo-Yin

AU - St Clair, David Malcolm

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AB - Linkage studies have suggested that chromosome 15q13-q14 may harbor a susceptibility locus for schizophrenia. In the current study, the association between a (TG)n dinucleotide repeat polymorphism at D15S976 and schizophrenia was investigated using two independent samples from the Han Chinese population. In a population-based study, no significant difference was found between the genotype and allele frequency distributions in schizophrenia patients and control subjects. In a family-based study, no significant transmission disequilibrium from heterozygous parents to affected offspring was observed. Further analysis of the parent-of-origin effect found nominally significant allele-wise transmission disequilibrium through maternal transmissions, while 157bp and 159bp alleles showed significant individual allelic transmission disequilibrium from heterozygous mothers to affected offspring. Our results did not support the hypothesis that the (TG)n dinucleotide repeat polymorphism plays a major role in schizophrenia susceptibility in the Chinese population. Further studies are needed to elucidate the putative parent-of-origin effect and its role in schizophrenia susceptibility. (C) 2007 Elsevier Ireland Ltd. All rights reserved.

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