Associations between fetal size, maternal α-tocopherol and childhood asthma

Stephen W Turner, Doris Campbell, Norman Smith, Leone C A Craig, Geraldine McNeill, Sarah H Forbes, Paul J Harbour, Anthony Seaton, Peter J Helms, Graham S Devereux

Research output: Contribution to journalArticle

61 Citations (Scopus)

Abstract

Background The origins of respiratory disease might be traced back to exposures during fetal life. The aim of the present study was to explore whether there was a relationship between fetal size and respiratory outcomes at 5 years of age in the context of fetal exposure to vitamin E.

Methods A longitudinal birth cohort study was recruited (n=1924). Antenatal ultrasound scan results were identified and the following recorded: crown–rump length (CRL) in the first trimester; femur length (FL) and biparietal diameter (BPD) in the second trimester. Maternal plasma α-tocopherol (vitamin E) was measured at the time of the first trimester scan. At 5 years, wheeze and asthma symptoms were reported by questionnaire, and spirometry was measured.

Results CRL, spirometry and questionnaire data at 5 years were available for 835, 579 and 1145 individuals, respectively. There were positive associations between CRL and forced expiratory volume in 1 s (FEV1; 5 ml increase in FEV1 per mm CRL, p=0.001, n=283), forced vital capacity (FVC; 6 ml increase in FVC per mm CRL, p=0.001) and forced expiratory flow between 25% and 75% of FVC (FEF25–75; 0.008 ml/s increase in FEF25–75 per mm CRL, p=0.023), and inverse relationships with CRL and current wheeze (OR 0.59 per CRL quartile, p=0.026, n=547) and asthma (OR 0.55 per CRL quartile p=0.011). CRL was positively associated with maternal plasma α-tocopherol (p=0.002).

Conclusions These findings support the concept of very early fetal programming of respiratory disease. Maternal vitamin E status may be one determinant for growth of the fetus and fetal lungs during early pregnancy.
Original languageEnglish
Pages (from-to)391-397
Number of pages7
JournalThorax
Volume65
Issue number5
DOIs
Publication statusPublished - 1 May 2010

Keywords

  • anthropometry
  • asthma
  • birth weight
  • child, preschool
  • cohort studies
  • crown-rump length
  • female
  • fetal development
  • forced expiratory volume
  • humans
  • hypersensitivity, immediate
  • infant, newborn
  • longitudinal studies
  • pregnancy
  • prenatal exposure delayed effects
  • prenatal nutritional physiological phenomena
  • respiratory sounds
  • ultrasonography, prenatal
  • vital capacity
  • alpha-tocopherol

Fingerprint Dive into the research topics of 'Associations between fetal size, maternal α-tocopherol and childhood asthma'. Together they form a unique fingerprint.

  • Cite this