Associations between fetal size, maternal α-tocopherol and childhood asthma

Stephen W Turner, Doris Campbell, Norman Smith, Leone C A Craig, Geraldine McNeill, Sarah H Forbes, Paul J Harbour, Anthony Seaton, Peter J Helms, Graham S Devereux

Research output: Contribution to journalArticle

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Abstract

Background The origins of respiratory disease might be traced back to exposures during fetal life. The aim of the present study was to explore whether there was a relationship between fetal size and respiratory outcomes at 5 years of age in the context of fetal exposure to vitamin E.

Methods A longitudinal birth cohort study was recruited (n=1924). Antenatal ultrasound scan results were identified and the following recorded: crown–rump length (CRL) in the first trimester; femur length (FL) and biparietal diameter (BPD) in the second trimester. Maternal plasma α-tocopherol (vitamin E) was measured at the time of the first trimester scan. At 5 years, wheeze and asthma symptoms were reported by questionnaire, and spirometry was measured.

Results CRL, spirometry and questionnaire data at 5 years were available for 835, 579 and 1145 individuals, respectively. There were positive associations between CRL and forced expiratory volume in 1 s (FEV1; 5 ml increase in FEV1 per mm CRL, p=0.001, n=283), forced vital capacity (FVC; 6 ml increase in FVC per mm CRL, p=0.001) and forced expiratory flow between 25% and 75% of FVC (FEF25–75; 0.008 ml/s increase in FEF25–75 per mm CRL, p=0.023), and inverse relationships with CRL and current wheeze (OR 0.59 per CRL quartile, p=0.026, n=547) and asthma (OR 0.55 per CRL quartile p=0.011). CRL was positively associated with maternal plasma α-tocopherol (p=0.002).

Conclusions These findings support the concept of very early fetal programming of respiratory disease. Maternal vitamin E status may be one determinant for growth of the fetus and fetal lungs during early pregnancy.
Original languageEnglish
Pages (from-to)391-397
Number of pages7
JournalThorax
Volume65
Issue number5
DOIs
Publication statusPublished - 1 May 2010

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Tocopherols
Vitamin E
Asthma
Spirometry
Mothers
First Pregnancy Trimester
Fetal Development
Vital Capacity
Forced Expiratory Volume
Second Pregnancy Trimester
Femur
Fetus
Cohort Studies
Parturition
Pregnancy
Lung
Surveys and Questionnaires

Keywords

  • anthropometry
  • asthma
  • birth weight
  • child, preschool
  • cohort studies
  • crown-rump length
  • female
  • fetal development
  • forced expiratory volume
  • humans
  • hypersensitivity, immediate
  • infant, newborn
  • longitudinal studies
  • pregnancy
  • prenatal exposure delayed effects
  • prenatal nutritional physiological phenomena
  • respiratory sounds
  • ultrasonography, prenatal
  • vital capacity
  • alpha-tocopherol

Cite this

Associations between fetal size, maternal α-tocopherol and childhood asthma. / Turner, Stephen W; Campbell, Doris; Smith, Norman; Craig, Leone C A; McNeill, Geraldine; Forbes, Sarah H; Harbour, Paul J; Seaton, Anthony; Helms, Peter J; Devereux, Graham S.

In: Thorax, Vol. 65, No. 5, 01.05.2010, p. 391-397.

Research output: Contribution to journalArticle

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abstract = "Background The origins of respiratory disease might be traced back to exposures during fetal life. The aim of the present study was to explore whether there was a relationship between fetal size and respiratory outcomes at 5 years of age in the context of fetal exposure to vitamin E.Methods A longitudinal birth cohort study was recruited (n=1924). Antenatal ultrasound scan results were identified and the following recorded: crown–rump length (CRL) in the first trimester; femur length (FL) and biparietal diameter (BPD) in the second trimester. Maternal plasma α-tocopherol (vitamin E) was measured at the time of the first trimester scan. At 5 years, wheeze and asthma symptoms were reported by questionnaire, and spirometry was measured.Results CRL, spirometry and questionnaire data at 5 years were available for 835, 579 and 1145 individuals, respectively. There were positive associations between CRL and forced expiratory volume in 1 s (FEV1; 5 ml increase in FEV1 per mm CRL, p=0.001, n=283), forced vital capacity (FVC; 6 ml increase in FVC per mm CRL, p=0.001) and forced expiratory flow between 25{\%} and 75{\%} of FVC (FEF25–75; 0.008 ml/s increase in FEF25–75 per mm CRL, p=0.023), and inverse relationships with CRL and current wheeze (OR 0.59 per CRL quartile, p=0.026, n=547) and asthma (OR 0.55 per CRL quartile p=0.011). CRL was positively associated with maternal plasma α-tocopherol (p=0.002).Conclusions These findings support the concept of very early fetal programming of respiratory disease. Maternal vitamin E status may be one determinant for growth of the fetus and fetal lungs during early pregnancy.",
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author = "Turner, {Stephen W} and Doris Campbell and Norman Smith and Craig, {Leone C A} and Geraldine McNeill and Forbes, {Sarah H} and Harbour, {Paul J} and Anthony Seaton and Helms, {Peter J} and Devereux, {Graham S}",
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T1 - Associations between fetal size, maternal α-tocopherol and childhood asthma

AU - Turner, Stephen W

AU - Campbell, Doris

AU - Smith, Norman

AU - Craig, Leone C A

AU - McNeill, Geraldine

AU - Forbes, Sarah H

AU - Harbour, Paul J

AU - Seaton, Anthony

AU - Helms, Peter J

AU - Devereux, Graham S

PY - 2010/5/1

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N2 - Background The origins of respiratory disease might be traced back to exposures during fetal life. The aim of the present study was to explore whether there was a relationship between fetal size and respiratory outcomes at 5 years of age in the context of fetal exposure to vitamin E.Methods A longitudinal birth cohort study was recruited (n=1924). Antenatal ultrasound scan results were identified and the following recorded: crown–rump length (CRL) in the first trimester; femur length (FL) and biparietal diameter (BPD) in the second trimester. Maternal plasma α-tocopherol (vitamin E) was measured at the time of the first trimester scan. At 5 years, wheeze and asthma symptoms were reported by questionnaire, and spirometry was measured.Results CRL, spirometry and questionnaire data at 5 years were available for 835, 579 and 1145 individuals, respectively. There were positive associations between CRL and forced expiratory volume in 1 s (FEV1; 5 ml increase in FEV1 per mm CRL, p=0.001, n=283), forced vital capacity (FVC; 6 ml increase in FVC per mm CRL, p=0.001) and forced expiratory flow between 25% and 75% of FVC (FEF25–75; 0.008 ml/s increase in FEF25–75 per mm CRL, p=0.023), and inverse relationships with CRL and current wheeze (OR 0.59 per CRL quartile, p=0.026, n=547) and asthma (OR 0.55 per CRL quartile p=0.011). CRL was positively associated with maternal plasma α-tocopherol (p=0.002).Conclusions These findings support the concept of very early fetal programming of respiratory disease. Maternal vitamin E status may be one determinant for growth of the fetus and fetal lungs during early pregnancy.

AB - Background The origins of respiratory disease might be traced back to exposures during fetal life. The aim of the present study was to explore whether there was a relationship between fetal size and respiratory outcomes at 5 years of age in the context of fetal exposure to vitamin E.Methods A longitudinal birth cohort study was recruited (n=1924). Antenatal ultrasound scan results were identified and the following recorded: crown–rump length (CRL) in the first trimester; femur length (FL) and biparietal diameter (BPD) in the second trimester. Maternal plasma α-tocopherol (vitamin E) was measured at the time of the first trimester scan. At 5 years, wheeze and asthma symptoms were reported by questionnaire, and spirometry was measured.Results CRL, spirometry and questionnaire data at 5 years were available for 835, 579 and 1145 individuals, respectively. There were positive associations between CRL and forced expiratory volume in 1 s (FEV1; 5 ml increase in FEV1 per mm CRL, p=0.001, n=283), forced vital capacity (FVC; 6 ml increase in FVC per mm CRL, p=0.001) and forced expiratory flow between 25% and 75% of FVC (FEF25–75; 0.008 ml/s increase in FEF25–75 per mm CRL, p=0.023), and inverse relationships with CRL and current wheeze (OR 0.59 per CRL quartile, p=0.026, n=547) and asthma (OR 0.55 per CRL quartile p=0.011). CRL was positively associated with maternal plasma α-tocopherol (p=0.002).Conclusions These findings support the concept of very early fetal programming of respiratory disease. Maternal vitamin E status may be one determinant for growth of the fetus and fetal lungs during early pregnancy.

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KW - asthma

KW - birth weight

KW - child, preschool

KW - cohort studies

KW - crown-rump length

KW - female

KW - fetal development

KW - forced expiratory volume

KW - humans

KW - hypersensitivity, immediate

KW - infant, newborn

KW - longitudinal studies

KW - pregnancy

KW - prenatal exposure delayed effects

KW - prenatal nutritional physiological phenomena

KW - respiratory sounds

KW - ultrasonography, prenatal

KW - vital capacity

KW - alpha-tocopherol

U2 - 10.1136/thx.2008.111385

DO - 10.1136/thx.2008.111385

M3 - Article

VL - 65

SP - 391

EP - 397

JO - Thorax

JF - Thorax

SN - 0040-6376

IS - 5

ER -