Asthma outcomes and costs of therapy with extrafine beclomethasone and fluticasone

Gene Colice, Richard J Martin, Elliot Israel, Nicolas Roche, Neil Barnes, Anne Burden, Peter Polos, Paul Dorinsky, Elizabeth V Hillyer, Amanda J. Lee, Alison Chisholm, Julie von Ziegenweidt, Francesca Barion, David Price

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Background: Characteristics of inhaled corticosteroids (ICSs) differ, but data comparing the real-life effectiveness of various ICSs for asthma are lacking.
Objective: We sought to compare real-life asthma outcomes and costs of extrafine hydrofluoroalkane (HFA)–beclomethasone and fluticasone administered through a pressurized metered-dose inhaler.
Methods: This retrospective matched cohort study examined database markers of asthma control from a large US longitudinal health care claims database over 1 baseline and 1 outcome year for 10,312 patients with asthma aged 12 to 80 years receiving their first ICS as HFA-beclomethasone or fluticasone and matched on baseline demographic characteristics and asthma severity.
Results: Patients started on HFA-beclomethasone had significantly higher odds (adjusted odds ratio, 1.19; 95% CI; 1.08-1.31) of achieving overall control (risk and impairment), which was defined as no hospital attendance for asthma, oral corticosteroids, or antibiotics for lower respiratory tract infection and less than 2 puffs per day of short-acting β-agonist; they also experienced a lower rate of respiratory-related hospitalizations or referrals (adjusted rate ratio, 0.82; 95% CI, 0.73-0.93) than patients started on fluticasone. Other database outcome measures were similar in the 2 cohorts. Prescribed HFA-beclomethasone doses were lower (P < .001) than fluticasone doses (median, 320 μg/d [interquartile range, 160-320 μg/d] vs 440 μg/d [interquartile range, 176-440 μg/d]). Adjusted respiratory-related health care costs were significantly lower for HFA-beclomethasone than fluticasone (mean, $1869 [95% CI, $1727-$2032] vs $2259 [95% CI, $2111-$2404]), representing a mean annual savings of $390 (95% CI, $165-$620) per patient prescribed HFA-beclomethasone rather than fluticasone.
Conclusions: Asthma treatment outcomes were similar or better with HFA-beclomethasone prescribed at significantly lower doses and with lower costs than fluticasone.
Original languageEnglish
Pages (from-to)45-54.e10
Number of pages20
JournalJournal of Allergy and Clinical Immunology
Issue number1
Early online date13 Apr 2013
Publication statusPublished - Jul 2013


  • Asthma control
  • beclomethasone dipropionate
  • extrafine particle
  • fluticasone propionate
  • observational study
  • United States

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    Colice, G., Martin, R. J., Israel, E., Roche, N., Barnes, N., Burden, A., Polos, P., Dorinsky, P., Hillyer, E. V., Lee, A. J., Chisholm, A., von Ziegenweidt, J., Barion, F., & Price, D. (2013). Asthma outcomes and costs of therapy with extrafine beclomethasone and fluticasone. Journal of Allergy and Clinical Immunology, 132(1), 45-54.e10.