Asymmetric organotellurides as potent antioxidants and building blocks of protein conjugates

Sandra Pariagh; Karen M. Tasker; Fiona H. Fry; Andrea L. Holme; Catriona A. Collins; Neal Okarter; Nick Gutowski; Claus Jacob

doi:10.1039/b500409h

Asymmetric organotellurides as potent antioxidants and building blocks of protein conjugates

Sandra Pariagh, Karen M. Tasker, Fiona H. Fry, Andrea L. Holme, Catriona A. Collins, Neal Okarter, Nick Gutowski, Claus Jacob^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

Asymmetric organotellurides were chosen as potent antioxidants to construct a catalyst-protein conjugate called human serum albumin (HSA). Amino and methoxy group were known to increase catalytic activity, and compounds were found to be highly active and readily attachable to transport proteins. The activity of the agents in both assays were comparable, with second order rate constants for H2O2 reduction and zinc release. A reasonable correlation between electron-rich substituents, on the aromatic ring, the first oxidation potential, and catalytic activity of chalcogen compounds were shown using cyclic voltammetry. The results confirm that it is possible to load chemically simple, yet catalytically highly active enzyme mimics onto HSA.

Original language	English
Pages (from-to)	975-980
Number of pages	6
Journal	Organic and Biomolecular Chemistry
Volume	3
Issue number	6
Early online date	14 Feb 2005
DOIs	https://doi.org/10.1039/b500409h
Publication status	Published - 21 Mar 2005
Externally published	Yes

Bibliographical note

Acknowledgements: This work was financially supported by the Leverhulme Trust, DAART, Exeter Antioxidant Therapeutics Ltd. and the University of Exeter.

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abstract = "Asymmetric organotellurides were chosen as potent antioxidants to construct a catalyst-protein conjugate called human serum albumin (HSA). Amino and methoxy group were known to increase catalytic activity, and compounds were found to be highly active and readily attachable to transport proteins. The activity of the agents in both assays were comparable, with second order rate constants for H2O2 reduction and zinc release. A reasonable correlation between electron-rich substituents, on the aromatic ring, the first oxidation potential, and catalytic activity of chalcogen compounds were shown using cyclic voltammetry. The results confirm that it is possible to load chemically simple, yet catalytically highly active enzyme mimics onto HSA.",

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AU - Pariagh, Sandra

AU - Tasker, Karen M.

AU - Fry, Fiona H.

AU - Holme, Andrea L.

AU - Collins, Catriona A.

AU - Okarter, Neal

AU - Gutowski, Nick

AU - Jacob, Claus

N1 - Acknowledgements: This work was financially supported by the Leverhulme Trust, DAART, Exeter Antioxidant Therapeutics Ltd. and the University of Exeter.

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N2 - Asymmetric organotellurides were chosen as potent antioxidants to construct a catalyst-protein conjugate called human serum albumin (HSA). Amino and methoxy group were known to increase catalytic activity, and compounds were found to be highly active and readily attachable to transport proteins. The activity of the agents in both assays were comparable, with second order rate constants for H2O2 reduction and zinc release. A reasonable correlation between electron-rich substituents, on the aromatic ring, the first oxidation potential, and catalytic activity of chalcogen compounds were shown using cyclic voltammetry. The results confirm that it is possible to load chemically simple, yet catalytically highly active enzyme mimics onto HSA.

AB - Asymmetric organotellurides were chosen as potent antioxidants to construct a catalyst-protein conjugate called human serum albumin (HSA). Amino and methoxy group were known to increase catalytic activity, and compounds were found to be highly active and readily attachable to transport proteins. The activity of the agents in both assays were comparable, with second order rate constants for H2O2 reduction and zinc release. A reasonable correlation between electron-rich substituents, on the aromatic ring, the first oxidation potential, and catalytic activity of chalcogen compounds were shown using cyclic voltammetry. The results confirm that it is possible to load chemically simple, yet catalytically highly active enzyme mimics onto HSA.

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Asymmetric organotellurides as potent antioxidants and building blocks of protein conjugates

Abstract

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