ATP economy of force maintenance in human tibialis anterior muscle

Y. Nakagawa, Aivaras Ratkevicius, M. Mizuno, B. Quistorff

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Purpose: The aim of this study was investigate ATP economy of force maintenance in the human tibialis anterior muscle during 60 s of anaerobic voluntary contraction at 50% of maximum voluntary contraction (MVC). Methods: ATP turnover rate was evaluated using 3 1 p magnetic resonance spectroscopy (P-31-MRS). The total volume of ankle dorsiflexor muscles was assessed by H-1 magnetic resonance imaging (MRI) (H-1-MRI), and the fiber type composition of the tibialis anterior muscle was evaluated using histochemical analysis of muscle biopsies. Results: The tibialis anterior muscle occupied 59.7 +/- 0.6% (mean +/- SEM) of the total ankle dorsiflexor muscle volume, which was 267 10 cm(3). Relative cross-sectional areas occupied by Type 1, IIA, and IIB fibers in the tibialis anterior were 69.3 +/- 2.2, 27.4 +/- 2.76, and 3.2 +/- 1.0%, respectively. ATP economy of force maintenance did not change significantly during the 60-s contraction. It averaged at 4.8 1 0.42 N(.)s(.)mu mol(-1), and correlated with the relative cross-sectional area of the muscle occupied by Type I fiber (r = 0.73, P < 0.01). For the second half of the contraction, subjects dropping in force showed lower ATP economy compared with those maintaining the force (3.7 +/- 0.6 vs 5.3 +/- 0.6 N(.)s(.)mu mol(-1); P < 0.05). Conclusion: It is argued that the unchanged ATP economy of force maintenance during the voluntary contraction could be due to an increase in the ATP economy of contracting muscle fibers offsetting the effects of increased temperature and low ATP economy of Type 11 fibers. Mechanical interaction between motor units could also act to improve ATP economy of force maintenance.

Original languageEnglish
Pages (from-to)937-943
Number of pages6
JournalMedicine and Science in Sports and Exercise
Volume37
Issue number6
DOIs
Publication statusPublished - Jun 2005

Keywords

  • phosphorus-31 magnetic resonance spectroscopy
  • phosphocreatine
  • energy cost
  • muscle fiber type
  • HUMAN SKELETAL-MUSCLE
  • FIBER-TYPE
  • CONTRACTIONS
  • EXERCISE
  • GASTROCNEMIUS
  • DORSIFLEXION
  • ACTIVATION
  • VOLUNTARY
  • NMR

Cite this

ATP economy of force maintenance in human tibialis anterior muscle. / Nakagawa, Y.; Ratkevicius, Aivaras; Mizuno, M.; Quistorff, B.

In: Medicine and Science in Sports and Exercise, Vol. 37, No. 6, 06.2005, p. 937-943.

Research output: Contribution to journalArticle

Nakagawa, Y. ; Ratkevicius, Aivaras ; Mizuno, M. ; Quistorff, B. / ATP economy of force maintenance in human tibialis anterior muscle. In: Medicine and Science in Sports and Exercise. 2005 ; Vol. 37, No. 6. pp. 937-943.
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abstract = "Purpose: The aim of this study was investigate ATP economy of force maintenance in the human tibialis anterior muscle during 60 s of anaerobic voluntary contraction at 50{\%} of maximum voluntary contraction (MVC). Methods: ATP turnover rate was evaluated using 3 1 p magnetic resonance spectroscopy (P-31-MRS). The total volume of ankle dorsiflexor muscles was assessed by H-1 magnetic resonance imaging (MRI) (H-1-MRI), and the fiber type composition of the tibialis anterior muscle was evaluated using histochemical analysis of muscle biopsies. Results: The tibialis anterior muscle occupied 59.7 +/- 0.6{\%} (mean +/- SEM) of the total ankle dorsiflexor muscle volume, which was 267 10 cm(3). Relative cross-sectional areas occupied by Type 1, IIA, and IIB fibers in the tibialis anterior were 69.3 +/- 2.2, 27.4 +/- 2.76, and 3.2 +/- 1.0{\%}, respectively. ATP economy of force maintenance did not change significantly during the 60-s contraction. It averaged at 4.8 1 0.42 N(.)s(.)mu mol(-1), and correlated with the relative cross-sectional area of the muscle occupied by Type I fiber (r = 0.73, P < 0.01). For the second half of the contraction, subjects dropping in force showed lower ATP economy compared with those maintaining the force (3.7 +/- 0.6 vs 5.3 +/- 0.6 N(.)s(.)mu mol(-1); P < 0.05). Conclusion: It is argued that the unchanged ATP economy of force maintenance during the voluntary contraction could be due to an increase in the ATP economy of contracting muscle fibers offsetting the effects of increased temperature and low ATP economy of Type 11 fibers. Mechanical interaction between motor units could also act to improve ATP economy of force maintenance.",
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T1 - ATP economy of force maintenance in human tibialis anterior muscle

AU - Nakagawa, Y.

AU - Ratkevicius, Aivaras

AU - Mizuno, M.

AU - Quistorff, B.

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Y1 - 2005/6

N2 - Purpose: The aim of this study was investigate ATP economy of force maintenance in the human tibialis anterior muscle during 60 s of anaerobic voluntary contraction at 50% of maximum voluntary contraction (MVC). Methods: ATP turnover rate was evaluated using 3 1 p magnetic resonance spectroscopy (P-31-MRS). The total volume of ankle dorsiflexor muscles was assessed by H-1 magnetic resonance imaging (MRI) (H-1-MRI), and the fiber type composition of the tibialis anterior muscle was evaluated using histochemical analysis of muscle biopsies. Results: The tibialis anterior muscle occupied 59.7 +/- 0.6% (mean +/- SEM) of the total ankle dorsiflexor muscle volume, which was 267 10 cm(3). Relative cross-sectional areas occupied by Type 1, IIA, and IIB fibers in the tibialis anterior were 69.3 +/- 2.2, 27.4 +/- 2.76, and 3.2 +/- 1.0%, respectively. ATP economy of force maintenance did not change significantly during the 60-s contraction. It averaged at 4.8 1 0.42 N(.)s(.)mu mol(-1), and correlated with the relative cross-sectional area of the muscle occupied by Type I fiber (r = 0.73, P < 0.01). For the second half of the contraction, subjects dropping in force showed lower ATP economy compared with those maintaining the force (3.7 +/- 0.6 vs 5.3 +/- 0.6 N(.)s(.)mu mol(-1); P < 0.05). Conclusion: It is argued that the unchanged ATP economy of force maintenance during the voluntary contraction could be due to an increase in the ATP economy of contracting muscle fibers offsetting the effects of increased temperature and low ATP economy of Type 11 fibers. Mechanical interaction between motor units could also act to improve ATP economy of force maintenance.

AB - Purpose: The aim of this study was investigate ATP economy of force maintenance in the human tibialis anterior muscle during 60 s of anaerobic voluntary contraction at 50% of maximum voluntary contraction (MVC). Methods: ATP turnover rate was evaluated using 3 1 p magnetic resonance spectroscopy (P-31-MRS). The total volume of ankle dorsiflexor muscles was assessed by H-1 magnetic resonance imaging (MRI) (H-1-MRI), and the fiber type composition of the tibialis anterior muscle was evaluated using histochemical analysis of muscle biopsies. Results: The tibialis anterior muscle occupied 59.7 +/- 0.6% (mean +/- SEM) of the total ankle dorsiflexor muscle volume, which was 267 10 cm(3). Relative cross-sectional areas occupied by Type 1, IIA, and IIB fibers in the tibialis anterior were 69.3 +/- 2.2, 27.4 +/- 2.76, and 3.2 +/- 1.0%, respectively. ATP economy of force maintenance did not change significantly during the 60-s contraction. It averaged at 4.8 1 0.42 N(.)s(.)mu mol(-1), and correlated with the relative cross-sectional area of the muscle occupied by Type I fiber (r = 0.73, P < 0.01). For the second half of the contraction, subjects dropping in force showed lower ATP economy compared with those maintaining the force (3.7 +/- 0.6 vs 5.3 +/- 0.6 N(.)s(.)mu mol(-1); P < 0.05). Conclusion: It is argued that the unchanged ATP economy of force maintenance during the voluntary contraction could be due to an increase in the ATP economy of contracting muscle fibers offsetting the effects of increased temperature and low ATP economy of Type 11 fibers. Mechanical interaction between motor units could also act to improve ATP economy of force maintenance.

KW - phosphorus-31 magnetic resonance spectroscopy

KW - phosphocreatine

KW - energy cost

KW - muscle fiber type

KW - HUMAN SKELETAL-MUSCLE

KW - FIBER-TYPE

KW - CONTRACTIONS

KW - EXERCISE

KW - GASTROCNEMIUS

KW - DORSIFLEXION

KW - ACTIVATION

KW - VOLUNTARY

KW - NMR

U2 - 10.1249/01.MSS.OOOO166946.94871.9B

DO - 10.1249/01.MSS.OOOO166946.94871.9B

M3 - Article

VL - 37

SP - 937

EP - 943

JO - Medicine and Science in Sports and Exercise

JF - Medicine and Science in Sports and Exercise

SN - 0195-9131

IS - 6

ER -