Atrial natriuretic factor release in postoperative cardiothoracic surgical patients

G P Ashcroft, S J Entwisle, C J Campbell, M P Holden, O N Keene

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Immunoreactive atrial natriuretic factor (ANF) levels were measured preoperatively and for 5 days postoperatively in 22 patients undergoing cardiothoracic surgery. They were studied in 4 groups according to surgical procedure (mitral valve replacement, aortic valve replacement, coronary artery bypass grafting, and lung resection). The highest preoperative ANF levels were observed in the aortic valve group (mean 40.9 pmol/L) which were 2.5 (95% CI: 0.7 to 8.6) to 3.5 (95% CI: 0.9 to 13.9) times higher than the other groups. Values tended to peak on the 3rd and 4th postoperative days in all groups, although significantly elevated postoperative ANF concentrations occurred only in the coronary artery bypass group where the levels increased by a factor of 3.2 (95% CI: 1.3 to 7.5). As a separate part of the study, measurement of ANF release before, during, and after cardiopulmonary bypass in 6 patients tended to show a fall in ANF levels when on bypass, with a return to baseline levels on cessation of bypass.
Original languageEnglish
Pages (from-to)220-3
Number of pages4
JournalThe Thoracic and cardiovascular surgeon
Volume38
Issue number4
DOIs
Publication statusPublished - 1990

Fingerprint

Atrial Natriuretic Factor
Aortic Valve
Coronary Artery Bypass
Cardiopulmonary Bypass
Mitral Valve
Lung

Cite this

Atrial natriuretic factor release in postoperative cardiothoracic surgical patients. / Ashcroft, G P; Entwisle, S J; Campbell, C J; Holden, M P; Keene, O N.

In: The Thoracic and cardiovascular surgeon, Vol. 38, No. 4, 1990, p. 220-3.

Research output: Contribution to journalArticle

Ashcroft, G P ; Entwisle, S J ; Campbell, C J ; Holden, M P ; Keene, O N. / Atrial natriuretic factor release in postoperative cardiothoracic surgical patients. In: The Thoracic and cardiovascular surgeon. 1990 ; Vol. 38, No. 4. pp. 220-3.
@article{d2569f3ec3594727a55afd80798b6088,
title = "Atrial natriuretic factor release in postoperative cardiothoracic surgical patients",
abstract = "Immunoreactive atrial natriuretic factor (ANF) levels were measured preoperatively and for 5 days postoperatively in 22 patients undergoing cardiothoracic surgery. They were studied in 4 groups according to surgical procedure (mitral valve replacement, aortic valve replacement, coronary artery bypass grafting, and lung resection). The highest preoperative ANF levels were observed in the aortic valve group (mean 40.9 pmol/L) which were 2.5 (95{\%} CI: 0.7 to 8.6) to 3.5 (95{\%} CI: 0.9 to 13.9) times higher than the other groups. Values tended to peak on the 3rd and 4th postoperative days in all groups, although significantly elevated postoperative ANF concentrations occurred only in the coronary artery bypass group where the levels increased by a factor of 3.2 (95{\%} CI: 1.3 to 7.5). As a separate part of the study, measurement of ANF release before, during, and after cardiopulmonary bypass in 6 patients tended to show a fall in ANF levels when on bypass, with a return to baseline levels on cessation of bypass.",
author = "Ashcroft, {G P} and Entwisle, {S J} and Campbell, {C J} and Holden, {M P} and Keene, {O N}",
year = "1990",
doi = "10.1055/s-2007-1014021",
language = "English",
volume = "38",
pages = "220--3",
journal = "The Thoracic and cardiovascular surgeon",
issn = "0171-6425",
publisher = "Georg Thieme Verlag",
number = "4",

}

TY - JOUR

T1 - Atrial natriuretic factor release in postoperative cardiothoracic surgical patients

AU - Ashcroft, G P

AU - Entwisle, S J

AU - Campbell, C J

AU - Holden, M P

AU - Keene, O N

PY - 1990

Y1 - 1990

N2 - Immunoreactive atrial natriuretic factor (ANF) levels were measured preoperatively and for 5 days postoperatively in 22 patients undergoing cardiothoracic surgery. They were studied in 4 groups according to surgical procedure (mitral valve replacement, aortic valve replacement, coronary artery bypass grafting, and lung resection). The highest preoperative ANF levels were observed in the aortic valve group (mean 40.9 pmol/L) which were 2.5 (95% CI: 0.7 to 8.6) to 3.5 (95% CI: 0.9 to 13.9) times higher than the other groups. Values tended to peak on the 3rd and 4th postoperative days in all groups, although significantly elevated postoperative ANF concentrations occurred only in the coronary artery bypass group where the levels increased by a factor of 3.2 (95% CI: 1.3 to 7.5). As a separate part of the study, measurement of ANF release before, during, and after cardiopulmonary bypass in 6 patients tended to show a fall in ANF levels when on bypass, with a return to baseline levels on cessation of bypass.

AB - Immunoreactive atrial natriuretic factor (ANF) levels were measured preoperatively and for 5 days postoperatively in 22 patients undergoing cardiothoracic surgery. They were studied in 4 groups according to surgical procedure (mitral valve replacement, aortic valve replacement, coronary artery bypass grafting, and lung resection). The highest preoperative ANF levels were observed in the aortic valve group (mean 40.9 pmol/L) which were 2.5 (95% CI: 0.7 to 8.6) to 3.5 (95% CI: 0.9 to 13.9) times higher than the other groups. Values tended to peak on the 3rd and 4th postoperative days in all groups, although significantly elevated postoperative ANF concentrations occurred only in the coronary artery bypass group where the levels increased by a factor of 3.2 (95% CI: 1.3 to 7.5). As a separate part of the study, measurement of ANF release before, during, and after cardiopulmonary bypass in 6 patients tended to show a fall in ANF levels when on bypass, with a return to baseline levels on cessation of bypass.

U2 - 10.1055/s-2007-1014021

DO - 10.1055/s-2007-1014021

M3 - Article

VL - 38

SP - 220

EP - 223

JO - The Thoracic and cardiovascular surgeon

JF - The Thoracic and cardiovascular surgeon

SN - 0171-6425

IS - 4

ER -