Autism With and Without Regression: A Two-Year Prospective Longitudinal Study in Two Population-Derived Swedish Cohorts

Lucy Thompson* (Corresponding Author), Christopher Gillberg, Sara Landberg, Anne-Katrin Kantzer, Carmela Miniscalco, Martina Barnevik Olsson, Mats A Eriksson, Elisabeth Fernell

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)
1 Downloads (Pure)

Abstract

Two community-based cohorts of children with autism spectrum disorder, examined using similar assessment protocols, were pooled (n=301) and subdivided according to history of regression. Those with regression (n=62), 20.5% of the combined cohort, were contrasted with those without regression (n=241) at first assessment (age range 19–60 months) and at 2-year follow-up on a range of measures. The regression group was significantly more functionally impaired, with regard to intellectual function (p<.001), language development (p<.001), and to severity of autism (p<.01) at both T1 and T2. Only 14 (23.3%) had a clearly identified underlying etiology [24 (18.6%) in the non-regressive group]. There were no significant differences between those who had regressed ‘from normal’ and those who had regressed ‘from low’ functioning.
Original languageEnglish
Pages (from-to)2281-2290
Number of pages10
JournalJournal of Autism & Developmental Disorders
Volume49
Early online date4 Feb 2019
DOIs
Publication statusPublished - 15 Jun 2019

Keywords

  • Autism
  • ASD
  • Regressive autism
  • Non-regressive autism
  • Intellectual developmental disorder
  • Developmental language disorder

Fingerprint Dive into the research topics of 'Autism With and Without Regression: A Two-Year Prospective Longitudinal Study in Two Population-Derived Swedish Cohorts'. Together they form a unique fingerprint.

Cite this