Autophagy: A new player in skeletal maintenance?

Lynne J Hocking, Caroline Whitehouse, Miep H Helfrich

Research output: Contribution to journalLiterature review

88 Citations (Scopus)

Abstract

Imbalances between bone resorption and formation lie at the root of disorders such as osteoporosis, Paget's disease of bone (PDB), and osteopetrosis. Recently, genetic and functional studies have implicated proteins involved in autophagic protein degradation as important mediators of bone cell function in normal physiology and in pathology. Autophagy is the conserved process whereby aggregated proteins, intracellular pathogens, and damaged organelles are degraded and recycled. This process is important both for normal cellular quality control and in response to environmental or internal stressors, particularly in terminally-differentiated cells. Autophagic structures can also act as hubs for the spatial organization of recycling and synthetic process in secretory cells. Alterations to autophagy (reduction, hyperactivation, or impairment) are associated with a number of disorders, including neurodegenerative diseases and cancers, and are now being implicated in maintenance of skeletal homoeostasis. Here, we introduce the topic of autophagy, describe the new findings that are starting to emerge from the bone field, and consider the therapeutic potential of modifying this pathway for the treatment of age-related bone disorders. © 2012 American Society for Bone and Mineral Research.
Original languageEnglish
Pages (from-to)1439-1447
Number of pages9
JournalJournal of Bone and Mineral Research
Volume27
Issue number7
Early online date15 Jun 2012
DOIs
Publication statusPublished - Jul 2012

Fingerprint

Autophagy
Maintenance
Bone and Bones
Osteopetrosis
Osteitis Deformans
Secretory Pathway
Recycling
Bone Resorption
Osteogenesis
Neurodegenerative Diseases
Quality Control
Organelles
Proteolysis
Osteoporosis
Proteins
Homeostasis
Pathology
Neoplasms
Therapeutics

Keywords

  • autophagy
  • bone
  • osteoclast
  • osteoblast
  • osteocyte

Cite this

Hocking, L. J., Whitehouse, C., & Helfrich, M. H. (2012). Autophagy: A new player in skeletal maintenance? Journal of Bone and Mineral Research, 27(7), 1439-1447. https://doi.org/10.1002/jbmr.1668

Autophagy : A new player in skeletal maintenance? / Hocking, Lynne J; Whitehouse, Caroline; Helfrich, Miep H.

In: Journal of Bone and Mineral Research, Vol. 27, No. 7, 07.2012, p. 1439-1447.

Research output: Contribution to journalLiterature review

Hocking, LJ, Whitehouse, C & Helfrich, MH 2012, 'Autophagy: A new player in skeletal maintenance?' Journal of Bone and Mineral Research, vol. 27, no. 7, pp. 1439-1447. https://doi.org/10.1002/jbmr.1668
Hocking, Lynne J ; Whitehouse, Caroline ; Helfrich, Miep H. / Autophagy : A new player in skeletal maintenance?. In: Journal of Bone and Mineral Research. 2012 ; Vol. 27, No. 7. pp. 1439-1447.
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