Abstract
Collagen-induced arthritis (CIA) is a chronic inflammatory arthropathy of rats which follows immunization with bovine type II collagen (bCII). T cell lines generated from arthritic rats have been shown to be self-reactive and proliferate in an autologous MLR, which is MHC-dependent. However, the peptides which drive this autoreactive response remain to be elucidated. T cell lines, generated initially to bCII, were cultured with synthetic peptides representing potential autoreactive self epitopes. C1q-c(50-64) peptide, which demonstrates sequence homology to the bCII(184-198) peptide, failed to stimulate T cell proliferation suggesting that the autologous MLR was not due to antigen cross-reactivity with this self peptide. In contrast, several peptides from the amino-terminal region of the RT1D(alpha) MHC class II molecule stimulated proliferative responses. These results suggest that immunization with bCII leads to activation of a population of autoreactive T cells which respond in an autologous MLR, and that this response could be due, in part, to T cell reactivity to self MHC peptides. (C) 2002 Published by Elsevier Science Ltd.
Original language | English |
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Pages (from-to) | 271-280 |
Number of pages | 10 |
Journal | Journal of Autoimmunity |
Volume | 18 |
DOIs | |
Publication status | Published - 2002 |
Keywords
- autoreactive T cells
- collagen-induced arthritis
- major histocompatibility complex
- type II collagen
- II COLLAGEN
- RHEUMATOID-ARTHRITIS
- AUTOIMMUNE ARTHRITIS
- MOLECULAR MIMICRY
- POSITIVE SELECTION
- REACTIVE ARTHRITIS
- STRUCTURAL BASIS
- LYMPHOCYTES-T
- PATHOGENESIS
- BINDING