Axillary lymph node metastases: A statistical analysis of various parameters in MRI with USPIO.

C. Stets, S. Brandt, F. Wallis, J. Buchmann, Fiona Jane Gilbert, S. H. Heywang-Kobrunner

Research output: Contribution to journalArticle

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Abstract

Purpose: To assess the value of plain vs. iron oxide-enhanced MRI vs. the combined study (plain + postcontrast) based on qualitative and quantitative parameters of three pulse sequences.

Materials and Methods: Data from two sites were acquired using the same technique; therefore, this data could be pooled. T1W-SE, T2W-FSE, and 3D-PSIF were used before and 24-36 hours after MRI with ultra small particles of iron oxide (USPIO) was performed. A total of 52 lymph nodes (LNs) in nine patients (25 benign, 27 malignant) were evaluated by two readers who were visually and quantitatively blinded to the histology. Combinations of the following diagnostic parameters were compared using logistic regression analysis: the short-axis diameter of the LN, the signal distribution of the LN on postcontrast agent MRI (homogeneous or heterogeneous), and qualitatively and quantitatively determined signal changes of the LN following administration of contrast agent in the three evaluated sequences.

Results: Using pre- and postcontrast data. the optimized accuracy based on the statistically most significant parameters (LN diameter > 6 mm, visual assessment of signal change on T2W-SE) was 87% (81% sensitivity, 92% specificity). Precontrast data alone yielded 75% accuracy (63% sensitivity, 86% specificity). Postcontrast data alone yielded 75% accuracy (56% sensitivity, 96% specificity).

Conclusion: Based on our results, USPIO-MRI improved the diagnosis of metastatic axillary LNs compared with precontrast MRI alone. Both pre- and postcontrast studies are needed. T1W-SE and T2W-PSIF did not yield significant additional information. This study may help to further improve the technique of USPIO imaging. (C) 2002 Wiley-Liss, Inc.

Original languageEnglish
Pages (from-to)60-68
Number of pages8
JournalJournal of Magnetic Resonance Imaging
Volume16
DOIs
Publication statusPublished - 2002

Keywords

  • contrast agent
  • MRI
  • lymph nodes
  • axilla
  • breast cancer
  • SUPERPARAMAGNETIC IRON-OXIDE
  • INITIAL CLINICAL-EXPERIENCE
  • PRIMARY BREAST-CANCER
  • CONTRAST AGENT
  • NECK-CANCER
  • LYMPHOGRAPHY
  • CARCINOMA
  • NUMBER
  • UPDATE
  • HEAD

Cite this

Stets, C., Brandt, S., Wallis, F., Buchmann, J., Gilbert, F. J., & Heywang-Kobrunner, S. H. (2002). Axillary lymph node metastases: A statistical analysis of various parameters in MRI with USPIO. Journal of Magnetic Resonance Imaging, 16, 60-68. https://doi.org/10.1002/jmri.10134

Axillary lymph node metastases: A statistical analysis of various parameters in MRI with USPIO. / Stets, C.; Brandt, S.; Wallis, F.; Buchmann, J.; Gilbert, Fiona Jane; Heywang-Kobrunner, S. H.

In: Journal of Magnetic Resonance Imaging, Vol. 16, 2002, p. 60-68.

Research output: Contribution to journalArticle

Stets, C, Brandt, S, Wallis, F, Buchmann, J, Gilbert, FJ & Heywang-Kobrunner, SH 2002, 'Axillary lymph node metastases: A statistical analysis of various parameters in MRI with USPIO.', Journal of Magnetic Resonance Imaging, vol. 16, pp. 60-68. https://doi.org/10.1002/jmri.10134
Stets, C. ; Brandt, S. ; Wallis, F. ; Buchmann, J. ; Gilbert, Fiona Jane ; Heywang-Kobrunner, S. H. / Axillary lymph node metastases: A statistical analysis of various parameters in MRI with USPIO. In: Journal of Magnetic Resonance Imaging. 2002 ; Vol. 16. pp. 60-68.
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abstract = "Purpose: To assess the value of plain vs. iron oxide-enhanced MRI vs. the combined study (plain + postcontrast) based on qualitative and quantitative parameters of three pulse sequences.Materials and Methods: Data from two sites were acquired using the same technique; therefore, this data could be pooled. T1W-SE, T2W-FSE, and 3D-PSIF were used before and 24-36 hours after MRI with ultra small particles of iron oxide (USPIO) was performed. A total of 52 lymph nodes (LNs) in nine patients (25 benign, 27 malignant) were evaluated by two readers who were visually and quantitatively blinded to the histology. Combinations of the following diagnostic parameters were compared using logistic regression analysis: the short-axis diameter of the LN, the signal distribution of the LN on postcontrast agent MRI (homogeneous or heterogeneous), and qualitatively and quantitatively determined signal changes of the LN following administration of contrast agent in the three evaluated sequences.Results: Using pre- and postcontrast data. the optimized accuracy based on the statistically most significant parameters (LN diameter > 6 mm, visual assessment of signal change on T2W-SE) was 87{\%} (81{\%} sensitivity, 92{\%} specificity). Precontrast data alone yielded 75{\%} accuracy (63{\%} sensitivity, 86{\%} specificity). Postcontrast data alone yielded 75{\%} accuracy (56{\%} sensitivity, 96{\%} specificity).Conclusion: Based on our results, USPIO-MRI improved the diagnosis of metastatic axillary LNs compared with precontrast MRI alone. Both pre- and postcontrast studies are needed. T1W-SE and T2W-PSIF did not yield significant additional information. This study may help to further improve the technique of USPIO imaging. (C) 2002 Wiley-Liss, Inc.",
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T1 - Axillary lymph node metastases: A statistical analysis of various parameters in MRI with USPIO.

AU - Stets, C.

AU - Brandt, S.

AU - Wallis, F.

AU - Buchmann, J.

AU - Gilbert, Fiona Jane

AU - Heywang-Kobrunner, S. H.

PY - 2002

Y1 - 2002

N2 - Purpose: To assess the value of plain vs. iron oxide-enhanced MRI vs. the combined study (plain + postcontrast) based on qualitative and quantitative parameters of three pulse sequences.Materials and Methods: Data from two sites were acquired using the same technique; therefore, this data could be pooled. T1W-SE, T2W-FSE, and 3D-PSIF were used before and 24-36 hours after MRI with ultra small particles of iron oxide (USPIO) was performed. A total of 52 lymph nodes (LNs) in nine patients (25 benign, 27 malignant) were evaluated by two readers who were visually and quantitatively blinded to the histology. Combinations of the following diagnostic parameters were compared using logistic regression analysis: the short-axis diameter of the LN, the signal distribution of the LN on postcontrast agent MRI (homogeneous or heterogeneous), and qualitatively and quantitatively determined signal changes of the LN following administration of contrast agent in the three evaluated sequences.Results: Using pre- and postcontrast data. the optimized accuracy based on the statistically most significant parameters (LN diameter > 6 mm, visual assessment of signal change on T2W-SE) was 87% (81% sensitivity, 92% specificity). Precontrast data alone yielded 75% accuracy (63% sensitivity, 86% specificity). Postcontrast data alone yielded 75% accuracy (56% sensitivity, 96% specificity).Conclusion: Based on our results, USPIO-MRI improved the diagnosis of metastatic axillary LNs compared with precontrast MRI alone. Both pre- and postcontrast studies are needed. T1W-SE and T2W-PSIF did not yield significant additional information. This study may help to further improve the technique of USPIO imaging. (C) 2002 Wiley-Liss, Inc.

AB - Purpose: To assess the value of plain vs. iron oxide-enhanced MRI vs. the combined study (plain + postcontrast) based on qualitative and quantitative parameters of three pulse sequences.Materials and Methods: Data from two sites were acquired using the same technique; therefore, this data could be pooled. T1W-SE, T2W-FSE, and 3D-PSIF were used before and 24-36 hours after MRI with ultra small particles of iron oxide (USPIO) was performed. A total of 52 lymph nodes (LNs) in nine patients (25 benign, 27 malignant) were evaluated by two readers who were visually and quantitatively blinded to the histology. Combinations of the following diagnostic parameters were compared using logistic regression analysis: the short-axis diameter of the LN, the signal distribution of the LN on postcontrast agent MRI (homogeneous or heterogeneous), and qualitatively and quantitatively determined signal changes of the LN following administration of contrast agent in the three evaluated sequences.Results: Using pre- and postcontrast data. the optimized accuracy based on the statistically most significant parameters (LN diameter > 6 mm, visual assessment of signal change on T2W-SE) was 87% (81% sensitivity, 92% specificity). Precontrast data alone yielded 75% accuracy (63% sensitivity, 86% specificity). Postcontrast data alone yielded 75% accuracy (56% sensitivity, 96% specificity).Conclusion: Based on our results, USPIO-MRI improved the diagnosis of metastatic axillary LNs compared with precontrast MRI alone. Both pre- and postcontrast studies are needed. T1W-SE and T2W-PSIF did not yield significant additional information. This study may help to further improve the technique of USPIO imaging. (C) 2002 Wiley-Liss, Inc.

KW - contrast agent

KW - MRI

KW - lymph nodes

KW - axilla

KW - breast cancer

KW - SUPERPARAMAGNETIC IRON-OXIDE

KW - INITIAL CLINICAL-EXPERIENCE

KW - PRIMARY BREAST-CANCER

KW - CONTRAST AGENT

KW - NECK-CANCER

KW - LYMPHOGRAPHY

KW - CARCINOMA

KW - NUMBER

KW - UPDATE

KW - HEAD

U2 - 10.1002/jmri.10134

DO - 10.1002/jmri.10134

M3 - Article

VL - 16

SP - 60

EP - 68

JO - Journal of Magnetic Resonance Imaging

JF - Journal of Magnetic Resonance Imaging

SN - 1053-1807

ER -