Bacterial ion channels

I. R. Booth*, M. A. Jones, D. McLaggan, Y. Nikolaev, L. S. Ness, C. M. Wood, S. Miller, S. Tötemeyer, G. P. Ferguson

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter

34 Citations (Scopus)

Abstract

This chapter reviews the evidence for channels in bacteria and evaluates their roles in cell physiology. Ion channels may play important roles in protection against excessive turgor pressure across the membrane (MscL, MscS, and possibly KefA) and during detoxification of electrophilic compounds (KefB, KefC). Other channels, such as KcsA, may play important roles in potassium acquisition or in balancing the potassium gradient with the membrane potential. The reality of Kch as a channel can only be a subject for speculation. However, if it were to function as an outwardly-rectified channel it might participate in membrane re-polarization during periods of starvation or, given its resemblance to the Ca2+-regulated, Drosophila slo channel, there may be a role for this channel in signaling the Ca2+ status of the cell. Other phenomena in bacteria may have their source in transport systems with channel-like properties. Most prominent among these is the Trk potassium transport system in Escherichia coli. For each of the proteins their open state has different implications for the cell and consequently tight regulation of opening is very important. The porins are open most of the time and are more correctly designated pores.
Original languageEnglish
Title of host publicationTransport Processes in Eukaryotic and Prokaryotic Organisms
Chapter30
Pages693-729
Number of pages37
Volume2
DOIs
Publication statusPublished - 1996

Publication series

NameHandbook of Biological Physics
ISSN (Print)1383-8121

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