Bacterial production of methylglyoxal

a survival strategy or death by misadventure?

Ian Rylance Booth, G. P. Ferguson, Sarah Christine Miller, Chan Li, Banuri Gunasekera, S Kinghorn

Research output: Contribution to journalArticle

115 Citations (Scopus)

Abstract

The production of MG (methylglyoxal) in bacterial cells must be maintained in balance with the capacity for detoxification and protection against this electrophile. Excessive production of MG leads to cell death. Survival of exposure to MG is best understood in the Gram-negative bacteria. The major mechanism of protection is the spontaneous reaction of MG with GSH to form hemithiolacetal, followed by detoxification by the glyoxalase system leading to the production of D-lactate. The KefB and KefC glutathione-gated K(+) efflux systems are integrated with the activity of the glyoxalase system to regulate the cytoplasmic pH in response to exposure to electrophiles. Bacteria only produce MG when an imbalance occurs in metabolism. Operation of the MG bypass enables cells to adapt, such that balance is restored to metabolism. Excessive production of MG is an adaptive ploy, which, if it fails, has fatal consequences. On this basis one might define MG-induced loss of life as "death by misadventure" rather than suicide!
Original languageEnglish
Pages (from-to)1406-1408
Number of pages3
JournalBiochemical Society Transactions
Volume31
Issue number6
Publication statusPublished - 1 Dec 2003

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Pyruvaldehyde
Detoxification
Metabolism
Bacteria
Cell death
Gram-Negative Bacteria
Suicide
Glutathione
Lactic Acid
Cell Death

Keywords

  • Bacteria
  • Pyruvaldehyde

Cite this

Booth, I. R., Ferguson, G. P., Miller, S. C., Li, C., Gunasekera, B., & Kinghorn, S. (2003). Bacterial production of methylglyoxal: a survival strategy or death by misadventure? Biochemical Society Transactions, 31(6), 1406-1408.

Bacterial production of methylglyoxal : a survival strategy or death by misadventure? / Booth, Ian Rylance; Ferguson, G. P.; Miller, Sarah Christine; Li, Chan; Gunasekera, Banuri; Kinghorn, S.

In: Biochemical Society Transactions, Vol. 31, No. 6, 01.12.2003, p. 1406-1408.

Research output: Contribution to journalArticle

Booth, IR, Ferguson, GP, Miller, SC, Li, C, Gunasekera, B & Kinghorn, S 2003, 'Bacterial production of methylglyoxal: a survival strategy or death by misadventure?', Biochemical Society Transactions, vol. 31, no. 6, pp. 1406-1408.
Booth IR, Ferguson GP, Miller SC, Li C, Gunasekera B, Kinghorn S. Bacterial production of methylglyoxal: a survival strategy or death by misadventure? Biochemical Society Transactions. 2003 Dec 1;31(6):1406-1408.
Booth, Ian Rylance ; Ferguson, G. P. ; Miller, Sarah Christine ; Li, Chan ; Gunasekera, Banuri ; Kinghorn, S. / Bacterial production of methylglyoxal : a survival strategy or death by misadventure?. In: Biochemical Society Transactions. 2003 ; Vol. 31, No. 6. pp. 1406-1408.
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