Bacteriophages with tails: chasing their origins and evolution

R W Hendrix, G F Hatfull, Margaret Caroline MacHin Smith

Research output: Contribution to journalArticle

71 Citations (Scopus)

Abstract

Comparative genomic analysis of the tailed bacteriophages shows that they are genetically mosaic with respect to each other, implying that horizontal exchange of sequences is an important component of their evolution. Horizontal exchange occurs intensively among closely related phages but also at reduced frequency across the entire population of tailed phages. It results in exchange of homologous functions, exchange of analogous but non-homologous functions as with the prophage integrases, and introduction of novel functions into the genome as with the morons. Extrapolation of these processes back in evolutionary time leads to a speculative model for the origins and early evolution of phages. (C) 2003 Editions scientifiques et medicales Elsevier SAS. All rights reserved.

Original languageEnglish
Pages (from-to)253-257
Number of pages5
JournalResearch in Microbiology
Volume154
Issue number4
DOIs
Publication statusPublished - May 2003

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Bacteriophages
Prophages
Integrases
Genome
Population

Keywords

  • bacteriophage
  • genome evolution
  • comparative genomics
  • genomic sequence
  • gene-expression
  • phage
  • viruses
  • PHI-C31

Cite this

Bacteriophages with tails : chasing their origins and evolution. / Hendrix, R W ; Hatfull, G F ; Smith, Margaret Caroline MacHin.

In: Research in Microbiology, Vol. 154, No. 4, 05.2003, p. 253-257.

Research output: Contribution to journalArticle

Hendrix, R W ; Hatfull, G F ; Smith, Margaret Caroline MacHin. / Bacteriophages with tails : chasing their origins and evolution. In: Research in Microbiology. 2003 ; Vol. 154, No. 4. pp. 253-257.
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