Basal metabolic rate and thyroid hormones of late-middle-aged and older human subjects

the ZENITH study

N Meunier, John Hamilton Beattie, D Ciarapica, Jacqueline M. O'Connor, M Andriollo-Sanchez, A Taras, C Coudray, A Polito

    Research output: Contribution to journalArticle

    9 Citations (Scopus)

    Abstract

    Objective: This paper describes baseline data on basal metabolic rate (BMR), thyroid hormone levels and body composition of middle-aged and older people participating in the ZENITH project and the correlation of thyroid hormone levels with zinc status.
    Design: A multicentre prospective intervention study employing a randomised double blind design.
    Setting: Clermont-Ferrand, Theix (France), Coleraine (Northern Ireland), Grenoble (France), Rome (Italy).
    Interventions: BMR has been measured on a subsample of 70 middle-aged volunteers (35 men and 35 women recruited in Clermont-Ferrand, France, aged 55-70 y) and 108 older volunteers (56 men and 52 women recruited in Rome, Italy, aged 70-85 y). Thyroid hormone levels were evaluated in the entire group of ZENITH volunteers (n = 387). BMR was measured by indirect calorimetry. Fat-free mass (FFM) was derived by four skinfold thicknesses using Durnin and Womersley's equations. Concentrations of thyroid hormones (total T3 and T4) were measured using a competitive immunoassay with an enhanced chemiluminescence end point.
    Results: Italian older volunteers had a significantly lower FFM than middle-aged French volunteers (-7% P<0.01). A negative correlation between BMR and age (men, r= -0.64; women, r= -0.62; both P<0.0001) was observed: BMR was significantly (P<0.000001) lower in Italian elderly volunteers (4.03 +/- 0.46 kJ/min and 3.29 +/- 0.42 kJ/min for men and women, respectively) than in middle-aged French volunteers (4.84 +/- 0.45 kJ/min and 3.87 +/- 0.38 kJ/min for men and women, respectively), even after adjustment for FFM (-12%). No correlation has been observed between BMR and thyroid hormones both in French and Italian subjects. Total T4 (T-174) concentrations were lowest in middle-aged population (-10%, P<0.0001). A moderate negative correlation has been found with TT4 and red blood cell zinc (r= -0.12, P<0.02, slope -0.026).
    Conclusions: The results confirm an age-related decline in BMR not entirely explained by body composition or thyroid hormones differences.

    Original languageEnglish
    Pages (from-to)S53-S57
    Number of pages5
    JournalEuropean Journal of Clinical Nutrition
    Volume59
    Issue numberSupplement 2
    DOIs
    Publication statusPublished - Nov 2005

    Keywords

    • basal metabolic rate
    • fat free mass
    • thyroid hormones
    • zinc
    • age
    • resting energy expenditure
    • body composition
    • zinc deficiency
    • healthy men
    • elderly men
    • thyroxine
    • turnover
    • fitness
    • decline
    • young

    Cite this

    Meunier, N., Beattie, J. H., Ciarapica, D., O'Connor, J. M., Andriollo-Sanchez, M., Taras, A., ... Polito, A. (2005). Basal metabolic rate and thyroid hormones of late-middle-aged and older human subjects: the ZENITH study. European Journal of Clinical Nutrition, 59(Supplement 2), S53-S57. https://doi.org/10.1038/sj.ejcn.1602299

    Basal metabolic rate and thyroid hormones of late-middle-aged and older human subjects : the ZENITH study. / Meunier, N ; Beattie, John Hamilton; Ciarapica, D ; O'Connor, Jacqueline M.; Andriollo-Sanchez, M ; Taras, A ; Coudray, C ; Polito, A .

    In: European Journal of Clinical Nutrition, Vol. 59, No. Supplement 2, 11.2005, p. S53-S57.

    Research output: Contribution to journalArticle

    Meunier, N, Beattie, JH, Ciarapica, D, O'Connor, JM, Andriollo-Sanchez, M, Taras, A, Coudray, C & Polito, A 2005, 'Basal metabolic rate and thyroid hormones of late-middle-aged and older human subjects: the ZENITH study', European Journal of Clinical Nutrition, vol. 59, no. Supplement 2, pp. S53-S57. https://doi.org/10.1038/sj.ejcn.1602299
    Meunier N, Beattie JH, Ciarapica D, O'Connor JM, Andriollo-Sanchez M, Taras A et al. Basal metabolic rate and thyroid hormones of late-middle-aged and older human subjects: the ZENITH study. European Journal of Clinical Nutrition. 2005 Nov;59(Supplement 2):S53-S57. https://doi.org/10.1038/sj.ejcn.1602299
    Meunier, N ; Beattie, John Hamilton ; Ciarapica, D ; O'Connor, Jacqueline M. ; Andriollo-Sanchez, M ; Taras, A ; Coudray, C ; Polito, A . / Basal metabolic rate and thyroid hormones of late-middle-aged and older human subjects : the ZENITH study. In: European Journal of Clinical Nutrition. 2005 ; Vol. 59, No. Supplement 2. pp. S53-S57.
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    abstract = "Objective: This paper describes baseline data on basal metabolic rate (BMR), thyroid hormone levels and body composition of middle-aged and older people participating in the ZENITH project and the correlation of thyroid hormone levels with zinc status. Design: A multicentre prospective intervention study employing a randomised double blind design. Setting: Clermont-Ferrand, Theix (France), Coleraine (Northern Ireland), Grenoble (France), Rome (Italy). Interventions: BMR has been measured on a subsample of 70 middle-aged volunteers (35 men and 35 women recruited in Clermont-Ferrand, France, aged 55-70 y) and 108 older volunteers (56 men and 52 women recruited in Rome, Italy, aged 70-85 y). Thyroid hormone levels were evaluated in the entire group of ZENITH volunteers (n = 387). BMR was measured by indirect calorimetry. Fat-free mass (FFM) was derived by four skinfold thicknesses using Durnin and Womersley's equations. Concentrations of thyroid hormones (total T3 and T4) were measured using a competitive immunoassay with an enhanced chemiluminescence end point. Results: Italian older volunteers had a significantly lower FFM than middle-aged French volunteers (-7{\%} P<0.01). A negative correlation between BMR and age (men, r= -0.64; women, r= -0.62; both P<0.0001) was observed: BMR was significantly (P<0.000001) lower in Italian elderly volunteers (4.03 +/- 0.46 kJ/min and 3.29 +/- 0.42 kJ/min for men and women, respectively) than in middle-aged French volunteers (4.84 +/- 0.45 kJ/min and 3.87 +/- 0.38 kJ/min for men and women, respectively), even after adjustment for FFM (-12{\%}). No correlation has been observed between BMR and thyroid hormones both in French and Italian subjects. Total T4 (T-174) concentrations were lowest in middle-aged population (-10{\%}, P<0.0001). A moderate negative correlation has been found with TT4 and red blood cell zinc (r= -0.12, P<0.02, slope -0.026). Conclusions: The results confirm an age-related decline in BMR not entirely explained by body composition or thyroid hormones differences.",
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    T1 - Basal metabolic rate and thyroid hormones of late-middle-aged and older human subjects

    T2 - the ZENITH study

    AU - Meunier, N

    AU - Beattie, John Hamilton

    AU - Ciarapica, D

    AU - O'Connor, Jacqueline M.

    AU - Andriollo-Sanchez, M

    AU - Taras, A

    AU - Coudray, C

    AU - Polito, A

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    N2 - Objective: This paper describes baseline data on basal metabolic rate (BMR), thyroid hormone levels and body composition of middle-aged and older people participating in the ZENITH project and the correlation of thyroid hormone levels with zinc status. Design: A multicentre prospective intervention study employing a randomised double blind design. Setting: Clermont-Ferrand, Theix (France), Coleraine (Northern Ireland), Grenoble (France), Rome (Italy). Interventions: BMR has been measured on a subsample of 70 middle-aged volunteers (35 men and 35 women recruited in Clermont-Ferrand, France, aged 55-70 y) and 108 older volunteers (56 men and 52 women recruited in Rome, Italy, aged 70-85 y). Thyroid hormone levels were evaluated in the entire group of ZENITH volunteers (n = 387). BMR was measured by indirect calorimetry. Fat-free mass (FFM) was derived by four skinfold thicknesses using Durnin and Womersley's equations. Concentrations of thyroid hormones (total T3 and T4) were measured using a competitive immunoassay with an enhanced chemiluminescence end point. Results: Italian older volunteers had a significantly lower FFM than middle-aged French volunteers (-7% P<0.01). A negative correlation between BMR and age (men, r= -0.64; women, r= -0.62; both P<0.0001) was observed: BMR was significantly (P<0.000001) lower in Italian elderly volunteers (4.03 +/- 0.46 kJ/min and 3.29 +/- 0.42 kJ/min for men and women, respectively) than in middle-aged French volunteers (4.84 +/- 0.45 kJ/min and 3.87 +/- 0.38 kJ/min for men and women, respectively), even after adjustment for FFM (-12%). No correlation has been observed between BMR and thyroid hormones both in French and Italian subjects. Total T4 (T-174) concentrations were lowest in middle-aged population (-10%, P<0.0001). A moderate negative correlation has been found with TT4 and red blood cell zinc (r= -0.12, P<0.02, slope -0.026). Conclusions: The results confirm an age-related decline in BMR not entirely explained by body composition or thyroid hormones differences.

    AB - Objective: This paper describes baseline data on basal metabolic rate (BMR), thyroid hormone levels and body composition of middle-aged and older people participating in the ZENITH project and the correlation of thyroid hormone levels with zinc status. Design: A multicentre prospective intervention study employing a randomised double blind design. Setting: Clermont-Ferrand, Theix (France), Coleraine (Northern Ireland), Grenoble (France), Rome (Italy). Interventions: BMR has been measured on a subsample of 70 middle-aged volunteers (35 men and 35 women recruited in Clermont-Ferrand, France, aged 55-70 y) and 108 older volunteers (56 men and 52 women recruited in Rome, Italy, aged 70-85 y). Thyroid hormone levels were evaluated in the entire group of ZENITH volunteers (n = 387). BMR was measured by indirect calorimetry. Fat-free mass (FFM) was derived by four skinfold thicknesses using Durnin and Womersley's equations. Concentrations of thyroid hormones (total T3 and T4) were measured using a competitive immunoassay with an enhanced chemiluminescence end point. Results: Italian older volunteers had a significantly lower FFM than middle-aged French volunteers (-7% P<0.01). A negative correlation between BMR and age (men, r= -0.64; women, r= -0.62; both P<0.0001) was observed: BMR was significantly (P<0.000001) lower in Italian elderly volunteers (4.03 +/- 0.46 kJ/min and 3.29 +/- 0.42 kJ/min for men and women, respectively) than in middle-aged French volunteers (4.84 +/- 0.45 kJ/min and 3.87 +/- 0.38 kJ/min for men and women, respectively), even after adjustment for FFM (-12%). No correlation has been observed between BMR and thyroid hormones both in French and Italian subjects. Total T4 (T-174) concentrations were lowest in middle-aged population (-10%, P<0.0001). A moderate negative correlation has been found with TT4 and red blood cell zinc (r= -0.12, P<0.02, slope -0.026). Conclusions: The results confirm an age-related decline in BMR not entirely explained by body composition or thyroid hormones differences.

    KW - basal metabolic rate

    KW - fat free mass

    KW - thyroid hormones

    KW - zinc

    KW - age

    KW - resting energy expenditure

    KW - body composition

    KW - zinc deficiency

    KW - healthy men

    KW - elderly men

    KW - thyroxine

    KW - turnover

    KW - fitness

    KW - decline

    KW - young

    U2 - 10.1038/sj.ejcn.1602299

    DO - 10.1038/sj.ejcn.1602299

    M3 - Article

    VL - 59

    SP - S53-S57

    JO - European Journal of Clinical Nutrition

    JF - European Journal of Clinical Nutrition

    SN - 0954-3007

    IS - Supplement 2

    ER -