Baseline MRI delivery characteristics predict change in invasive ductal breast carcinoma PET metabolism as a result of primary chemotherapy administration

Scott Ian Kay Semple, Roger T Staff, Steven Darryll Heys, Thomas William Redpath, Andrew Welch, Trevor Sean Ahearn, A. W. Hutcheon, Fiona Jane Gilbert

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Background: The aim of the study was to investigate whether pre-therapy vascular delivery assessment [using dynamic contrast enhanced magnetic resonance imaging (DCE-MRI)] can predict reduction in breast cancer metabolism [detected using 2-[F-18] fluoro-2-deoxy-D-glucose positron emission tomography ((18)F(-)FDG-PET)] after a single cycle of chemotherapy. Reduction in F-18-FDG PET metabolism has previously been shown to correlate with histological response to primary chemotherapy.

Patients and methods: Seventeen patients with large or locally advanced invasive ductal carcinomas of the breast were imaged using DCE-MRI and F-18-FDG-PET prior to therapy and 20 days after the first cycle of chemotherapy. MRI data were analysed using a multi-compartment model. PET data were analysed using standardised uptake value (SUV) analysis.

Results: A significant association (P < 0.05) was observed between pre-therapy DCE-MRI vascular parameters and the reduction in PET metabolism resulting from administration of one cycle of chemotherapy.

Conclusions: A relationship was demonstrated between pre-therapy DCE-MRI vascular parameters and the reduction in PET metabolism after a single cycle of chemotherapy. This suggests that reduction in PET metabolism as a result of chemotherapy may be dependent, at least in part, on pre-therapy vascular delivery. These pre-therapy vascular characteristics may be suitable for use as a surrogate measure for initial chemotherapy delivery, a key factor in chemotherapeutic efficacy.

Original languageEnglish
Pages (from-to)1393-1398
Number of pages5
JournalAnnals of Oncology
Volume17
DOIs
Publication statusPublished - Sep 2006

Keywords

  • breast cancer
  • dynamic MRI
  • F-18-FDG PET
  • chemotherapy
  • efficacy
  • delivery
  • POSITRON-EMISSION-TOMOGRAPHY
  • CONTRAST-ENHANCED MRI
  • NEOADJUVANT CHEMOTHERAPY
  • PREOPERATIVE CHEMOTHERAPY
  • RIM ENHANCEMENT
  • CANCER
  • THERAPY
  • DIAGNOSIS
  • MASSES
  • TUMORS

Cite this

Baseline MRI delivery characteristics predict change in invasive ductal breast carcinoma PET metabolism as a result of primary chemotherapy administration. / Semple, Scott Ian Kay; Staff, Roger T; Heys, Steven Darryll; Redpath, Thomas William; Welch, Andrew; Ahearn, Trevor Sean; Hutcheon, A. W.; Gilbert, Fiona Jane.

In: Annals of Oncology, Vol. 17, 09.2006, p. 1393-1398.

Research output: Contribution to journalArticle

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title = "Baseline MRI delivery characteristics predict change in invasive ductal breast carcinoma PET metabolism as a result of primary chemotherapy administration",
abstract = "Background: The aim of the study was to investigate whether pre-therapy vascular delivery assessment [using dynamic contrast enhanced magnetic resonance imaging (DCE-MRI)] can predict reduction in breast cancer metabolism [detected using 2-[F-18] fluoro-2-deoxy-D-glucose positron emission tomography ((18)F(-)FDG-PET)] after a single cycle of chemotherapy. Reduction in F-18-FDG PET metabolism has previously been shown to correlate with histological response to primary chemotherapy.Patients and methods: Seventeen patients with large or locally advanced invasive ductal carcinomas of the breast were imaged using DCE-MRI and F-18-FDG-PET prior to therapy and 20 days after the first cycle of chemotherapy. MRI data were analysed using a multi-compartment model. PET data were analysed using standardised uptake value (SUV) analysis.Results: A significant association (P < 0.05) was observed between pre-therapy DCE-MRI vascular parameters and the reduction in PET metabolism resulting from administration of one cycle of chemotherapy.Conclusions: A relationship was demonstrated between pre-therapy DCE-MRI vascular parameters and the reduction in PET metabolism after a single cycle of chemotherapy. This suggests that reduction in PET metabolism as a result of chemotherapy may be dependent, at least in part, on pre-therapy vascular delivery. These pre-therapy vascular characteristics may be suitable for use as a surrogate measure for initial chemotherapy delivery, a key factor in chemotherapeutic efficacy.",
keywords = "breast cancer, dynamic MRI, F-18-FDG PET, chemotherapy, efficacy, delivery, POSITRON-EMISSION-TOMOGRAPHY, CONTRAST-ENHANCED MRI, NEOADJUVANT CHEMOTHERAPY, PREOPERATIVE CHEMOTHERAPY, RIM ENHANCEMENT, CANCER, THERAPY, DIAGNOSIS, MASSES, TUMORS",
author = "Semple, {Scott Ian Kay} and Staff, {Roger T} and Heys, {Steven Darryll} and Redpath, {Thomas William} and Andrew Welch and Ahearn, {Trevor Sean} and Hutcheon, {A. W.} and Gilbert, {Fiona Jane}",
year = "2006",
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T1 - Baseline MRI delivery characteristics predict change in invasive ductal breast carcinoma PET metabolism as a result of primary chemotherapy administration

AU - Semple, Scott Ian Kay

AU - Staff, Roger T

AU - Heys, Steven Darryll

AU - Redpath, Thomas William

AU - Welch, Andrew

AU - Ahearn, Trevor Sean

AU - Hutcheon, A. W.

AU - Gilbert, Fiona Jane

PY - 2006/9

Y1 - 2006/9

N2 - Background: The aim of the study was to investigate whether pre-therapy vascular delivery assessment [using dynamic contrast enhanced magnetic resonance imaging (DCE-MRI)] can predict reduction in breast cancer metabolism [detected using 2-[F-18] fluoro-2-deoxy-D-glucose positron emission tomography ((18)F(-)FDG-PET)] after a single cycle of chemotherapy. Reduction in F-18-FDG PET metabolism has previously been shown to correlate with histological response to primary chemotherapy.Patients and methods: Seventeen patients with large or locally advanced invasive ductal carcinomas of the breast were imaged using DCE-MRI and F-18-FDG-PET prior to therapy and 20 days after the first cycle of chemotherapy. MRI data were analysed using a multi-compartment model. PET data were analysed using standardised uptake value (SUV) analysis.Results: A significant association (P < 0.05) was observed between pre-therapy DCE-MRI vascular parameters and the reduction in PET metabolism resulting from administration of one cycle of chemotherapy.Conclusions: A relationship was demonstrated between pre-therapy DCE-MRI vascular parameters and the reduction in PET metabolism after a single cycle of chemotherapy. This suggests that reduction in PET metabolism as a result of chemotherapy may be dependent, at least in part, on pre-therapy vascular delivery. These pre-therapy vascular characteristics may be suitable for use as a surrogate measure for initial chemotherapy delivery, a key factor in chemotherapeutic efficacy.

AB - Background: The aim of the study was to investigate whether pre-therapy vascular delivery assessment [using dynamic contrast enhanced magnetic resonance imaging (DCE-MRI)] can predict reduction in breast cancer metabolism [detected using 2-[F-18] fluoro-2-deoxy-D-glucose positron emission tomography ((18)F(-)FDG-PET)] after a single cycle of chemotherapy. Reduction in F-18-FDG PET metabolism has previously been shown to correlate with histological response to primary chemotherapy.Patients and methods: Seventeen patients with large or locally advanced invasive ductal carcinomas of the breast were imaged using DCE-MRI and F-18-FDG-PET prior to therapy and 20 days after the first cycle of chemotherapy. MRI data were analysed using a multi-compartment model. PET data were analysed using standardised uptake value (SUV) analysis.Results: A significant association (P < 0.05) was observed between pre-therapy DCE-MRI vascular parameters and the reduction in PET metabolism resulting from administration of one cycle of chemotherapy.Conclusions: A relationship was demonstrated between pre-therapy DCE-MRI vascular parameters and the reduction in PET metabolism after a single cycle of chemotherapy. This suggests that reduction in PET metabolism as a result of chemotherapy may be dependent, at least in part, on pre-therapy vascular delivery. These pre-therapy vascular characteristics may be suitable for use as a surrogate measure for initial chemotherapy delivery, a key factor in chemotherapeutic efficacy.

KW - breast cancer

KW - dynamic MRI

KW - F-18-FDG PET

KW - chemotherapy

KW - efficacy

KW - delivery

KW - POSITRON-EMISSION-TOMOGRAPHY

KW - CONTRAST-ENHANCED MRI

KW - NEOADJUVANT CHEMOTHERAPY

KW - PREOPERATIVE CHEMOTHERAPY

KW - RIM ENHANCEMENT

KW - CANCER

KW - THERAPY

KW - DIAGNOSIS

KW - MASSES

KW - TUMORS

U2 - 10.1093/annonc/mdl136

DO - 10.1093/annonc/mdl136

M3 - Article

VL - 17

SP - 1393

EP - 1398

JO - Annals of Oncology

JF - Annals of Oncology

SN - 0923-7534

ER -