Baseline MRI delivery characteristics predict change in invasive ductal breast carcinoma PET metabolism as a result of primary chemotherapy administration

Scott Ian Kay Semple, Roger T Staff, Steven Darryll Heys, Thomas William Redpath, Andrew Welch, Trevor Sean Ahearn, A. W. Hutcheon, Fiona Jane Gilbert

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21 Citations (Scopus)

Abstract

Background: The aim of the study was to investigate whether pre-therapy vascular delivery assessment [using dynamic contrast enhanced magnetic resonance imaging (DCE-MRI)] can predict reduction in breast cancer metabolism [detected using 2-[F-18] fluoro-2-deoxy-D-glucose positron emission tomography ((18)F(-)FDG-PET)] after a single cycle of chemotherapy. Reduction in F-18-FDG PET metabolism has previously been shown to correlate with histological response to primary chemotherapy.

Patients and methods: Seventeen patients with large or locally advanced invasive ductal carcinomas of the breast were imaged using DCE-MRI and F-18-FDG-PET prior to therapy and 20 days after the first cycle of chemotherapy. MRI data were analysed using a multi-compartment model. PET data were analysed using standardised uptake value (SUV) analysis.

Results: A significant association (P < 0.05) was observed between pre-therapy DCE-MRI vascular parameters and the reduction in PET metabolism resulting from administration of one cycle of chemotherapy.

Conclusions: A relationship was demonstrated between pre-therapy DCE-MRI vascular parameters and the reduction in PET metabolism after a single cycle of chemotherapy. This suggests that reduction in PET metabolism as a result of chemotherapy may be dependent, at least in part, on pre-therapy vascular delivery. These pre-therapy vascular characteristics may be suitable for use as a surrogate measure for initial chemotherapy delivery, a key factor in chemotherapeutic efficacy.

Original languageEnglish
Pages (from-to)1393-1398
Number of pages5
JournalAnnals of Oncology
Volume17
DOIs
Publication statusPublished - Sep 2006

Keywords

  • breast cancer
  • dynamic MRI
  • F-18-FDG PET
  • chemotherapy
  • efficacy
  • delivery
  • POSITRON-EMISSION-TOMOGRAPHY
  • CONTRAST-ENHANCED MRI
  • NEOADJUVANT CHEMOTHERAPY
  • PREOPERATIVE CHEMOTHERAPY
  • RIM ENHANCEMENT
  • CANCER
  • THERAPY
  • DIAGNOSIS
  • MASSES
  • TUMORS

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