Baseline overall health-related quality of life predicts the 10-year incidence of cardiovascular events in a Chinese population

Gaoqiang Xie, Henyun Zou, Phyo Kyaw Myint, Ping Shi, Fuxiu Ren, Wei Gao, Yangfeng Wu

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

OBJECTIVE: To determine the relationship between baseline overall HRQOL as well as domain-specific HRQOL and incident cardiovascular (CV) events over 10 years of follow-up in a Chinese general population.

METHODS: We examined the above link using data from a prospective cohort study, conducted between 2002 and 2012 in 11 villages of Beijing. HRQOL was assessed using Chinese 35-item quality of life instrument, and CV risk factors were recorded in either 2002 or 2005. Subjects were followed through the end of the study period, or until they were censored due to an incident CV event [including myocardial infarction (MI) and stroke] or loss to follow-up.

RESULTS: A total of 1739 participants were eligible to be included in the current study [female 64.2 %, age 57.7 (8.4) years]. There were a total of 190 CV events during the follow-up (14,364 total person-years). Participants in the bottom 20 % had 85 % increase in risk of CV event [hazard ratio (HR) 1.85; 95 % CI 1.14-3.02] compared to those in top 20 % of overall HRQOL, after adjusting for sex, age, education, marital status, smoking, alcohol consumption, being physically active, hypertension, diabetes, high cholesterol, and obesity. Among the six HRQOL domains, the independence domain had the largest effect size (fully adjusted HR 2.91; 95 % CI 1.67-5.07), followed by physical domain (HR 1.66; 95 % CI 1.03-2.67). Other domains did not predict the incidence CV events in this cohort.

CONCLUSIONS: While overall lower HRQOL predicts subsequent risk of stroke and MI events, this appeared to be driven mainly by the independence domain.

Original languageEnglish
Pages (from-to)363-371
Number of pages9
JournalQuality of Life Research
Volume25
Issue number2
Early online date14 Jul 2015
DOIs
Publication statusPublished - Feb 2016

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Stroke
Myocardial Infarction
Quality of Life
Sex Education
Incidence
Marital Status
Alcohol Drinking
Population
Cohort Studies
Obesity
Smoking
Cholesterol
Prospective Studies
Hypertension
Beijing

Keywords

  • health-related quality of life
  • cardiovascular incidence
  • prospective cohort study
  • stroke
  • myocardial infarction

Cite this

Baseline overall health-related quality of life predicts the 10-year incidence of cardiovascular events in a Chinese population. / Xie, Gaoqiang; Zou, Henyun; Myint, Phyo Kyaw; Shi, Ping; Ren, Fuxiu; Gao, Wei; Wu, Yangfeng.

In: Quality of Life Research, Vol. 25, No. 2, 02.2016, p. 363-371.

Research output: Contribution to journalArticle

Xie, Gaoqiang ; Zou, Henyun ; Myint, Phyo Kyaw ; Shi, Ping ; Ren, Fuxiu ; Gao, Wei ; Wu, Yangfeng. / Baseline overall health-related quality of life predicts the 10-year incidence of cardiovascular events in a Chinese population. In: Quality of Life Research. 2016 ; Vol. 25, No. 2. pp. 363-371.
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author = "Gaoqiang Xie and Henyun Zou and Myint, {Phyo Kyaw} and Ping Shi and Fuxiu Ren and Wei Gao and Yangfeng Wu",
note = "Date of Acceptance: 07/07/2015 Acknowledgments: We thank all scientists from USA and China for their hard work to establish the study cohort and a series of international standardized methods. We also thank all study participants. Compliance with ethical standards Funding: This study was supported by grants from the People’s Republic of China National 10th Five-Year Plan Science and Technology Key Projects (Grant No. 2001BA703B01), the National Natural Science Foundation of China (Grant Nos. 30471494 and 30872168)",
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T1 - Baseline overall health-related quality of life predicts the 10-year incidence of cardiovascular events in a Chinese population

AU - Xie, Gaoqiang

AU - Zou, Henyun

AU - Myint, Phyo Kyaw

AU - Shi, Ping

AU - Ren, Fuxiu

AU - Gao, Wei

AU - Wu, Yangfeng

N1 - Date of Acceptance: 07/07/2015 Acknowledgments: We thank all scientists from USA and China for their hard work to establish the study cohort and a series of international standardized methods. We also thank all study participants. Compliance with ethical standards Funding: This study was supported by grants from the People’s Republic of China National 10th Five-Year Plan Science and Technology Key Projects (Grant No. 2001BA703B01), the National Natural Science Foundation of China (Grant Nos. 30471494 and 30872168)

PY - 2016/2

Y1 - 2016/2

N2 - OBJECTIVE: To determine the relationship between baseline overall HRQOL as well as domain-specific HRQOL and incident cardiovascular (CV) events over 10 years of follow-up in a Chinese general population.METHODS: We examined the above link using data from a prospective cohort study, conducted between 2002 and 2012 in 11 villages of Beijing. HRQOL was assessed using Chinese 35-item quality of life instrument, and CV risk factors were recorded in either 2002 or 2005. Subjects were followed through the end of the study period, or until they were censored due to an incident CV event [including myocardial infarction (MI) and stroke] or loss to follow-up.RESULTS: A total of 1739 participants were eligible to be included in the current study [female 64.2 %, age 57.7 (8.4) years]. There were a total of 190 CV events during the follow-up (14,364 total person-years). Participants in the bottom 20 % had 85 % increase in risk of CV event [hazard ratio (HR) 1.85; 95 % CI 1.14-3.02] compared to those in top 20 % of overall HRQOL, after adjusting for sex, age, education, marital status, smoking, alcohol consumption, being physically active, hypertension, diabetes, high cholesterol, and obesity. Among the six HRQOL domains, the independence domain had the largest effect size (fully adjusted HR 2.91; 95 % CI 1.67-5.07), followed by physical domain (HR 1.66; 95 % CI 1.03-2.67). Other domains did not predict the incidence CV events in this cohort.CONCLUSIONS: While overall lower HRQOL predicts subsequent risk of stroke and MI events, this appeared to be driven mainly by the independence domain.

AB - OBJECTIVE: To determine the relationship between baseline overall HRQOL as well as domain-specific HRQOL and incident cardiovascular (CV) events over 10 years of follow-up in a Chinese general population.METHODS: We examined the above link using data from a prospective cohort study, conducted between 2002 and 2012 in 11 villages of Beijing. HRQOL was assessed using Chinese 35-item quality of life instrument, and CV risk factors were recorded in either 2002 or 2005. Subjects were followed through the end of the study period, or until they were censored due to an incident CV event [including myocardial infarction (MI) and stroke] or loss to follow-up.RESULTS: A total of 1739 participants were eligible to be included in the current study [female 64.2 %, age 57.7 (8.4) years]. There were a total of 190 CV events during the follow-up (14,364 total person-years). Participants in the bottom 20 % had 85 % increase in risk of CV event [hazard ratio (HR) 1.85; 95 % CI 1.14-3.02] compared to those in top 20 % of overall HRQOL, after adjusting for sex, age, education, marital status, smoking, alcohol consumption, being physically active, hypertension, diabetes, high cholesterol, and obesity. Among the six HRQOL domains, the independence domain had the largest effect size (fully adjusted HR 2.91; 95 % CI 1.67-5.07), followed by physical domain (HR 1.66; 95 % CI 1.03-2.67). Other domains did not predict the incidence CV events in this cohort.CONCLUSIONS: While overall lower HRQOL predicts subsequent risk of stroke and MI events, this appeared to be driven mainly by the independence domain.

KW - health-related quality of life

KW - cardiovascular incidence

KW - prospective cohort study

KW - stroke

KW - myocardial infarction

U2 - 10.1007/s11136-015-1066-8

DO - 10.1007/s11136-015-1066-8

M3 - Article

VL - 25

SP - 363

EP - 371

JO - Quality of Life Research

JF - Quality of Life Research

SN - 0962-9343

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