Beclometasone dipropionate extrafine aerosol versus fluticasone propionate in children with asthma

W. M. C. Van Aalderen*, D. Price, F. M. De Baets, J. Price

*Corresponding author for this work

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Beclometasone dipropionate (BDP) extrafine is a hydrofluoroalkane-based, chlorofluorocarbon (CFC)-free inhalation aerosol. This study was conducted to determine whether BDP extrafine and CFC-fluticasone proprionate (FP) aerosols were equivalent in terms of efficacy and tolerability in children with symptomatic mild-to-moderate asthma. Male and female patients (aged 5–12 yr) with an asthma diagnosis for X3 months, peak expiratory flow (PEF) X60% of predicted normal and suboptimal asthma control were randomised to double-blind treatment with BDP extrafine 200 mg day1 (n ¼ 139) or CFC-FP 200 mg day1 (n ¼ 141) for up to 18 weeks. After 6 and 12 weeks, study medication was ‘stepped down’ to 100 and 50 mg day1 , respectively, if patients had achieved good asthma control. Patients with poor asthma control discontinued from the study and those with intermediate control continued in the study but did not undergo a dose reduction. The estimated treatment difference in morning PEF% predicted at 6 weeks was 1.9% (90% CI 4.9, 1.0). There was a trend towards a greater increase in forced vital capacity (% predicted) in the BDP extrafine group (5.3 versus 0.4%; p ¼ 0.084). A ‘step-down’ in therapy to 100 mg day1 was possible in 36% and 42% of patients in the BDP extrafine and CFC-FP groups, respectively, at 6 weeks. Both drugs were well tolerated. BDP extrafine and CFC-FP aerosols were equally effective at improving asthma control in children with mild-to-moderate asthma at the same daily dose.
Original languageEnglish
Pages (from-to)1585-1593
Number of pages9
JournalRespiratory Medicine
Volume101
Issue number7
Early online date24 Jan 2007
DOIs
Publication statusPublished - 1 Jul 2007

Keywords

  • asthma
  • beclometasone diproprionate
  • children
  • HFA 134a
  • extrafine aerosol
  • administration inhalation

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