Behavioural and physiological responses to increased foraging effort in male mice

Lobke Maria Vaanholt, Berber De Jong, Theodore Garland Jr, Serge Daan, G. Henk Visser

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

Free-living animals must forage for food and hence may face energetic constraints imposed by their natural environmental conditions (e.g. ambient temperature, food availability). Simulating the variation in such constraints, we have experimentally manipulated the rate of work (wheel running) mice must do to obtain their food, and studied the ensuing behavioural and physiological responses. This was done with a line of mice selectively bred for high spontaneous wheel running and a randomly bred control line that vary in the amount of baseline wheel-running activity. We first determined the maximum workload for each individual. The maximum workload animals could engage in was around 23 km d(-1) in both control and activity-selected mice, and was not associated with baseline wheel-running activity. We then kept mice at 90% of their individual maximum and measured several physiological and behavioural traits. At this high workload, mice increased wheel-running activity from an average of 10 to 20 km d(-1), and decreased food intake and body mass by approximately 20%. Mass-specific resting metabolic rate strongly decreased from 1.43 to 0.98 kJ g(-1) d(-1), whereas daily energy expenditure slightly increased from 2.09 to 2.25 kJ g(-1) d(-1). Costs of running decreased from 2.3 to 1.6 kJ km(-1) between baseline and workload conditions. At high workloads, animals were in a negative energy balance, resulting in a sharp reduction in fat mass as well as a slight decrease in dry lean mass. In addition, corticosterone levels increased, and body temperature was extremely low in some animals at high workloads. When challenged to work for food, mice thus show significant physiological and behavioural adjustments.
Original languageEnglish
Pages (from-to)2013-2024
Number of pages12
JournalJournal of Experimental Biology
Volume210
Issue number11
DOIs
Publication statusPublished - 1 Jun 2007

Fingerprint

physiological response
behavioral response
Workload
Running
wheels
foraging
animal
mice
food
Food
body temperature
food intake
animals
food availability
body mass
energy balance
fat
breeds
forage
expenditure

Keywords

  • animals
  • body temperature
  • body weight
  • eating
  • energy metabolism
  • male
  • mice
  • motor activity
  • mouse
  • daily energy expenditure
  • doubly labeled water technique
  • energy balance
  • resting metabolic rate

Cite this

Vaanholt, L. M., De Jong, B., Garland Jr, T., Daan, S., & Visser, G. H. (2007). Behavioural and physiological responses to increased foraging effort in male mice. Journal of Experimental Biology, 210(11), 2013-2024. https://doi.org/10.1242/jeb.001974

Behavioural and physiological responses to increased foraging effort in male mice. / Vaanholt, Lobke Maria; De Jong, Berber; Garland Jr, Theodore; Daan, Serge; Visser, G. Henk.

In: Journal of Experimental Biology, Vol. 210, No. 11, 01.06.2007, p. 2013-2024.

Research output: Contribution to journalArticle

Vaanholt, LM, De Jong, B, Garland Jr, T, Daan, S & Visser, GH 2007, 'Behavioural and physiological responses to increased foraging effort in male mice', Journal of Experimental Biology, vol. 210, no. 11, pp. 2013-2024. https://doi.org/10.1242/jeb.001974
Vaanholt, Lobke Maria ; De Jong, Berber ; Garland Jr, Theodore ; Daan, Serge ; Visser, G. Henk. / Behavioural and physiological responses to increased foraging effort in male mice. In: Journal of Experimental Biology. 2007 ; Vol. 210, No. 11. pp. 2013-2024.
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