Bench-to-bedside review: targeting antioxidants to mitochondria in sepsis

Research output: Contribution to journalLiterature review

80 Citations (Scopus)
4 Downloads (Pure)

Abstract

Development of organ dysfunction associated with sepsis is now accepted to be due at least in part to oxidative damage to mitochondria. Under normal circumstances, complex interacting antioxidant defense systems control oxidative stress within mitochondria. However, no studies have yet provided conclusive evidence of the beneficial effect of antioxidant supplementation in patients with sepsis. This may be because the antioxidants are not accumulating in the mitochondria, where they are most needed. Antioxidants can be targeted selectively to mitochondria by several means. This review describes the in vitro studies and animal models of several diseases involving oxidative stress, including sepsis, in which antioxidants targeted at mitochondria have shown promise, and the future implications for such approaches in patients.
Original languageEnglish
Article number230
Number of pages9
JournalCritical Care
Volume14
Issue number4
DOIs
Publication statusPublished - 20 Aug 2010

Fingerprint

Sepsis
Mitochondria
Antioxidants
Oxidative Stress
Animal Disease Models

Cite this

Bench-to-bedside review : targeting antioxidants to mitochondria in sepsis. / Galley, Helen F.

In: Critical Care, Vol. 14, No. 4, 230, 20.08.2010.

Research output: Contribution to journalLiterature review

@article{cac6d8325f214277b0690985ac24bd7b,
title = "Bench-to-bedside review: targeting antioxidants to mitochondria in sepsis",
abstract = "Development of organ dysfunction associated with sepsis is now accepted to be due at least in part to oxidative damage to mitochondria. Under normal circumstances, complex interacting antioxidant defense systems control oxidative stress within mitochondria. However, no studies have yet provided conclusive evidence of the beneficial effect of antioxidant supplementation in patients with sepsis. This may be because the antioxidants are not accumulating in the mitochondria, where they are most needed. Antioxidants can be targeted selectively to mitochondria by several means. This review describes the in vitro studies and animal models of several diseases involving oxidative stress, including sepsis, in which antioxidants targeted at mitochondria have shown promise, and the future implications for such approaches in patients.",
author = "Galley, {Helen F}",
year = "2010",
month = "8",
day = "20",
doi = "10.1186/cc9098",
language = "English",
volume = "14",
journal = "Critical Care",
issn = "1364-8535",
publisher = "Springer Science + Business Media",
number = "4",

}

TY - JOUR

T1 - Bench-to-bedside review

T2 - targeting antioxidants to mitochondria in sepsis

AU - Galley, Helen F

PY - 2010/8/20

Y1 - 2010/8/20

N2 - Development of organ dysfunction associated with sepsis is now accepted to be due at least in part to oxidative damage to mitochondria. Under normal circumstances, complex interacting antioxidant defense systems control oxidative stress within mitochondria. However, no studies have yet provided conclusive evidence of the beneficial effect of antioxidant supplementation in patients with sepsis. This may be because the antioxidants are not accumulating in the mitochondria, where they are most needed. Antioxidants can be targeted selectively to mitochondria by several means. This review describes the in vitro studies and animal models of several diseases involving oxidative stress, including sepsis, in which antioxidants targeted at mitochondria have shown promise, and the future implications for such approaches in patients.

AB - Development of organ dysfunction associated with sepsis is now accepted to be due at least in part to oxidative damage to mitochondria. Under normal circumstances, complex interacting antioxidant defense systems control oxidative stress within mitochondria. However, no studies have yet provided conclusive evidence of the beneficial effect of antioxidant supplementation in patients with sepsis. This may be because the antioxidants are not accumulating in the mitochondria, where they are most needed. Antioxidants can be targeted selectively to mitochondria by several means. This review describes the in vitro studies and animal models of several diseases involving oxidative stress, including sepsis, in which antioxidants targeted at mitochondria have shown promise, and the future implications for such approaches in patients.

U2 - 10.1186/cc9098

DO - 10.1186/cc9098

M3 - Literature review

VL - 14

JO - Critical Care

JF - Critical Care

SN - 1364-8535

IS - 4

M1 - 230

ER -