TY - JOUR
T1 - Beneficial effect of soy isoflavones and soy isoflavones plus soy protein on serum concentration of C-reactive protein among postmenopausal women
T2 - An updated systematic review and meta-analysis of randomized controlled trials
AU - Hariri, Mitra
AU - Ghasemi, Ahmad
AU - Baradaran, Hamid Reza
AU - Mollanoroozy, Ensieyh
AU - Gholami, Ali
N1 - Financial support: This systematic review and meta-analysis was financially supported by Neyshabur University of Medical Sciences (Grant number: 98-01-149. Ethical code: IR.NUMS.REC.1399.006).
We are extremely grateful to the data collection team at the Neyshabur University of Medical Sciences.
PY - 2021/6/1
Y1 - 2021/6/1
N2 - BACKGROUND: Scientists suggest that soy isoflavones or the combination of soy isoflavones and soy protein may have beneficial effects on inflammation. Thus, the present study aims at conducting a systematic review and meta-analysis on randomized controlled trials (RCTs) in which the effect of soy isoflavones and the combination of soy isoflavones and soy protein on serum concentration of C-reactive protein (CRP) among postmenopausal women is assessed.METHODS AND MATERIALS: A literature searching was done to identify a breadth of related references in PubMed, Scopus, ISI Web of Science, Cochrane Library, and Clinicaltrials.gov up to December 2020. The mean change from baseline in the CRP concentrations and its standard deviation (SD) for both intervention and comparison groups were used to calculate the effect size. The summary of the overall effects and heterogeneity was estimated by using the DerSimonian and Laird random effects model. The protocol was registered with PROSPERO (No. CRD42020166053).RESULTS: This study considered 23 articles for systematic review and 19 articles for meta-analysis. The overall effect presented a non-significant effect of soy isoflavones on serum CRP concentrations (WMD = 0.08 mg/L, 95% CI: -0.08, 0.24; p = 0.302) and the overall effect of the combination of soy isoflavones and soy protein indicated non-significant effect in serum levels of CRP (WMD= -0.02 mg/L 95% CI: -0.12, 0.08; p = 0.715).CONCLUSION: Published RCTs did not provide strong evidence regarding beneficial effect of soy isoflavones or the combination of soy isoflavones and soy protein on serum CRP concentration among postmenopausal women.
AB - BACKGROUND: Scientists suggest that soy isoflavones or the combination of soy isoflavones and soy protein may have beneficial effects on inflammation. Thus, the present study aims at conducting a systematic review and meta-analysis on randomized controlled trials (RCTs) in which the effect of soy isoflavones and the combination of soy isoflavones and soy protein on serum concentration of C-reactive protein (CRP) among postmenopausal women is assessed.METHODS AND MATERIALS: A literature searching was done to identify a breadth of related references in PubMed, Scopus, ISI Web of Science, Cochrane Library, and Clinicaltrials.gov up to December 2020. The mean change from baseline in the CRP concentrations and its standard deviation (SD) for both intervention and comparison groups were used to calculate the effect size. The summary of the overall effects and heterogeneity was estimated by using the DerSimonian and Laird random effects model. The protocol was registered with PROSPERO (No. CRD42020166053).RESULTS: This study considered 23 articles for systematic review and 19 articles for meta-analysis. The overall effect presented a non-significant effect of soy isoflavones on serum CRP concentrations (WMD = 0.08 mg/L, 95% CI: -0.08, 0.24; p = 0.302) and the overall effect of the combination of soy isoflavones and soy protein indicated non-significant effect in serum levels of CRP (WMD= -0.02 mg/L 95% CI: -0.12, 0.08; p = 0.715).CONCLUSION: Published RCTs did not provide strong evidence regarding beneficial effect of soy isoflavones or the combination of soy isoflavones and soy protein on serum CRP concentration among postmenopausal women.
KW - Soy isoflavones
KW - Soy protein
KW - Postmenopausal women
KW - C-reactive protein
U2 - 10.1016/j.ctim.2021.102715
DO - 10.1016/j.ctim.2021.102715
M3 - Review article
C2 - 33785457
VL - 59
JO - Complementary Therapies in Medicine
JF - Complementary Therapies in Medicine
SN - 0965-2299
M1 - 102715
ER -